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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SERPINF2
check button Gene summary
Basic gene informationGene symbolSERPINF2
Gene nameserpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SynonymsA2AP|AAP|ALPHA-2-PI|API|PLI
CytomapUCSC genome browser: 17p13
Type of geneprotein-coding
RefGenesNM_000934.3,
NM_001165920.1,NM_001165921.1,
Descriptionalpha-2-APalpha-2-antiplasminalpha-2-plasmin inhibitorserine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2serpin F2
Modification date20141207
dbXrefs MIM : 613168
HGNC : HGNC
Ensembl : ENSG00000167711
HPRD : 02029
Vega : OTTHUMG00000090552
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SERPINF2
BioGPS: 5345
PathwayNCI Pathway Interaction Database: SERPINF2
KEGG: SERPINF2
REACTOME: SERPINF2
Pathway Commons: SERPINF2
ContextiHOP: SERPINF2
ligand binding site mutation search in PubMed: SERPINF2
UCL Cancer Institute: SERPINF2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)KidneyLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICHLIHC
Reference showing the relevant tissue of SERPINF2
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0010757negative regulation of plasminogen activation134998
GO:0032967positive regulation of collagen biosynthetic process17958745
GO:0045597positive regulation of cell differentiation20008146
GO:0045944positive regulation of transcription from RNA polymerase II promoter17958745
GO:0046330positive regulation of JNK cascade20008146
GO:0051496positive regulation of stress fiber assembly20008146
GO:0051918negative regulation of fibrinolysis134998
GO:0070374positive regulation of ERK1 and ERK2 cascade20008146
GO:0071636positive regulation of transforming growth factor beta production17958745
GO:0010757negative regulation of plasminogen activation134998
GO:0032967positive regulation of collagen biosynthetic process17958745
GO:0045597positive regulation of cell differentiation20008146
GO:0045944positive regulation of transcription from RNA polymerase II promoter17958745
GO:0046330positive regulation of JNK cascade20008146
GO:0051496positive regulation of stress fiber assembly20008146
GO:0051918negative regulation of fibrinolysis134998
GO:0070374positive regulation of ERK1 and ERK2 cascade20008146
GO:0071636positive regulation of transforming growth factor beta production17958745


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TissGeneExp for SERPINF2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LIHC7.189611279.27889327-2.0892829.45E-098.30E-08
KIRC5.0342284373.4869506591.5472777782.61E-087.61E-08
LUSC0.1676022121.724184565-1.5565823532.19E-097.25E-09
KICH-2.073858733.05295727-5.1268163.17E-145.03E-13
BRCA-1.3378165190.153100148-1.4909166672.16E-191.47E-18
KIRP2.684155524.26866177-1.584506257.60E-050.000268334


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TissGene-miRNA for SERPINF2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for SERPINF2
TissGeneSNV for SERPINF2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R33WCOAD1
p.E358KSKCM1
p.T212ALUAD1
p.K445NLUSC1
p.I204TBRCA1
p.E392KSKCM1
p.L476FUCEC1
p.R434KCOAD1
p.R276HPAAD1
p.G68RSKCM1
p.Q371HLUAD1
p.Q55XKIRC1
p.Q134HSTAD1
p.S405FCESC1
p.L230FSTAD1
p.A395VSTAD1
p.D92NCOAD1
p.M345IUCEC1
p.V191MSTAD1
p.A2TCOAD1
p.L476ILGG1
p.S109LPRAD1
p.G156VESCA1
p.H137QLUSC1
p.L416FSKCM1
p.S405PSTAD1
p.E388KCOAD1
p.R271HESCA1
p.A396VSKCM1
p.L220FSKCM1
p.Q55*KIRC1
p.R161QUCEC1
p.P414SSKCM1
p.I368TSKCM1
p.M86TSKCM1
p.E176QLUSC1
p.L301FSKCM1
p.G68ESKCM1
p.D455GLGG1
p.G488SSARC1
p.V265MUCEC1
p.R330KUCEC1
p.P436TCOAD1
p.L93MSTAD1
p.C152YCOAD1
p.M28ISKCM1


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TissGeneCNV for SERPINF2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SERPINF2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABG564112SERPINF2-HPS3chr17:1646215chr3:148890707


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TissGeneNet for SERPINF2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (tumor)SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (normal)
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COAD (tumor)COAD (normal)
SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (tumor)SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (normal)
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HNSC (tumor)HNSC (normal)
SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (tumor)SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (normal)
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KICH (tumor)KICH (normal)
SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (tumor)SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (normal)
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KIRC (tumor)KIRC (normal)
SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (tumor)SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (normal)
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KIRP (tumor)KIRP (normal)
SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (tumor)SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (normal)
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LIHC (tumor)LIHC (normal)
SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (tumor)SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (normal)
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LUAD (tumor)LUAD (normal)
SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (tumor)SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (normal)
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LUSC (tumor)LUSC (normal)
SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (tumor)SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (normal)
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PRAD (tumor)PRAD (normal)
SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (tumor)SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (normal)
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STAD (tumor)STAD (normal)
SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (tumor)SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (normal)
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THCA (tumor)THCA (normal)
SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (tumor)SERPINF2, ELANE, PLAU, PLG, BCAP31, F13A1, TGM2, FGA, KLK2, F11, SSR1, KLK6, PRSS1, SERPINB12, KLK13, CTRB1, CFD (normal)
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TissGeneProg for SERPINF2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SERPINF2
TissGeneDrug for SERPINF2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SERPINF2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0038395Streptococcal Infections23BeFree
umls:C0038160Staphylococcal Infections19BeFree
umls:C0005779Blood Coagulation Disorders7BeFree,GAD
umls:C0019087Hemorrhagic Disorders3BeFree
umls:C0524620Metabolic Syndrome X2BeFree
umls:C0002395Alzheimer's Disease1GAD
umls:C0003873Rheumatoid Arthritis1BeFree
umls:C0004096Asthma1BeFree
umls:C0007137Squamous cell carcinoma1LHGDN
umls:C0020473Hyperlipidemia1RGD
umls:C0025229Melioidosis1BeFree
umls:C0027051Myocardial Infarction1BeFree
umls:C0027831Neurofibromatosis 11BeFree
umls:C0029408Degenerative polyarthritis1BeFree
umls:C0034065Pulmonary Embolism1LHGDN
umls:C0034155Purpura, Thrombotic Thrombocytopenic1BeFree
umls:C0036341Schizophrenia1BeFree
umls:C0085082Fungemia1BeFree
umls:C0162678Neurofibromatoses1BeFree
umls:C0267941Pancreatitis, Acute Necrotizing1RGD
umls:C0268394Hereditary Cerebral Amyloid Angiopathy, Dutch Type1BeFree
umls:C0272274Familial hemorrhagic diathesis1BeFree
umls:C0342546Premature adrenarche1BeFree
umls:C0398620Alpha-2-antiplasmin deficiency1BeFree
umls:C0476089Endometrial Carcinoma1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C1458140Bleeding tendency1GAD
umls:C2752081ALPHA-2-PLASMIN INHIBITOR DEFICIENCY1CLINVAR,MGD,ORPHANET,UNIPROT
umls:C3489734Anti-plasmin deficiency, congenital0CTD_human