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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for FXYD3
check button Gene summary
Basic gene informationGene symbolFXYD3
Gene nameFXYD domain containing ion transport regulator 3
SynonymsMAT8|PLML
CytomapUCSC genome browser: 19q13.12
Type of geneprotein-coding
RefGenesNM_001136007.1,
NM_001136008.1,NM_001136009.1,NM_001136010.1,NM_001136011.1,
NM_001136012.1,NM_005971.3,NM_021910.2,
DescriptionFXYD domain-containing ion transport regulator 3chloride conductance inducer protein Mat-8mammary tumor 8 kDa proteinphospholemman-like protein
Modification date20141207
dbXrefs MIM : 604996
HGNC : HGNC
Ensembl : ENSG00000089356
HPRD : 05410
Vega : OTTHUMG00000184625
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FXYD3
BioGPS: 5349
PathwayNCI Pathway Interaction Database: FXYD3
KEGG: FXYD3
REACTOME: FXYD3
Pathway Commons: FXYD3
ContextiHOP: FXYD3
ligand binding site mutation search in PubMed: FXYD3
UCL Cancer Institute: FXYD3
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BladderColon
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)BLCACOAD
Reference showing the relevant tissue of FXYD3
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for FXYD3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-3.1442819020.346302098-3.4905843.08E-058.90E-05
COAD5.766267797.400148559-1.6338807697.24E-096.70E-08
KIRP-5.481089902-0.445818027-5.0352718751.57E-154.63E-14
LUAD2.9162411324.293439408-1.3771982761.60E-054.58E-05
BRCA4.519609222.781875011.7377342119.66E-113.80E-10
KIRC-3.516596847-0.575824625-2.9407722222.49E-161.40E-15
THCA-2.688603462-5.4989000722.810296612.60E-081.23E-07


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TissGene-miRNA for FXYD3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for FXYD3
TissGeneSNV for FXYD3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.V113IPAAD1
p.V104FCESC1
p.A43VREAD1
p.E59*PRAD1
p.N84IUCEC1
p.C44WHNSC1
p.H92NLUSC1
p.F68CBRCA1
p.S40FTHYM1
p.C37WLUAD1
p.P16SSKCM1
p.S85NUCEC1
p.H92NPAAD1
p.D57NBLCA1
p.V56IPAAD1
p.V17LBLCA1


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TissGeneCNV for FXYD3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for FXYD3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAAI274165FXYD3-ZNF202chr19:35614564chr11:123596885
Chimerdb3.0FusionScanBRCATCGA-A2-A04U-01ALSM14A-FXYD3In-Framechr19:34706566chr19:35610071
Chimerdb3.0FusionScanESCATCGA-LN-A8HZ-01AFXYD3-NAPRT1Out-of-Framechr19:35612149chr8:144657070
Chimerdb3.0TopHat-FusionBLCATCGA-DK-A3X2-01AFXYD3-TARM1In-Framechr19:35610319chr19:54579169
TCGAfusionPortalPRADABLCATCGA-DK-A3X2-01AFXYD3-TARM1In-frameChr19:35610320Chr19:54579170
TCGAfusionPortalPRADABLCATCGA-GD-A3OP-01AFXYD3-ZNFX13UTR-CDSChr19:35615227Chr20:47863418


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TissGeneNet for FXYD3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (tumor)FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (normal)
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COAD (tumor)COAD (normal)
FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (tumor)FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (normal)
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HNSC (tumor)HNSC (normal)
FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (tumor)FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (normal)
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KICH (tumor)KICH (normal)
FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (tumor)FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (normal)
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KIRC (tumor)KIRC (normal)
FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (tumor)FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (normal)
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KIRP (tumor)KIRP (normal)
FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (tumor)FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (normal)
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LIHC (tumor)LIHC (normal)
FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (tumor)FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (normal)
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LUAD (tumor)LUAD (normal)
FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (tumor)FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (normal)
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LUSC (tumor)LUSC (normal)
FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (tumor)FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (normal)
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PRAD (tumor)PRAD (normal)
FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (tumor)FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (normal)
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STAD (tumor)STAD (normal)
FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (tumor)FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (normal)
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THCA (tumor)THCA (normal)
FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (tumor)FXYD3, NUDT3, NR4A1, MAPK6, SERBP1, FBXL12 (normal)
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TissGeneProg for FXYD3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for FXYD3
TissGeneDrug for FXYD3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for FXYD3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0009402Colorectal Carcinoma3BeFree
umls:C1527249Colorectal Cancer3BeFree
umls:C0235974Pancreatic carcinoma2BeFree
umls:C0346647Malignant neoplasm of pancreas2BeFree
umls:C0596263Carcinogenesis2BeFree
umls:C0686619Secondary malignant neoplasm of lymph node2BeFree
umls:C0002793Anaplasia1BeFree
umls:C0009404Colorectal Neoplasms1LHGDN
umls:C0030297Pancreatic Neoplasm1CTD_human,LHGDN
umls:C0033578Prostatic Neoplasms1BeFree,LHGDN
umls:C0149521Pancreatitis, Chronic1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1704272Benign Prostatic Hyperplasia1BeFree