TissGeneSummary for IL20RB |
Gene summary |
Basic gene information | Gene symbol | IL20RB |
Gene name | interleukin 20 receptor beta | |
Synonyms | DIRS1|FNDC6|IL-20R2 | |
Cytomap | UCSC genome browser: 3q22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_144717.3, | |
Description | IL-20 receptor subunit betaIL-20R-betaIL-20RBfibronectin type III domain containing 6interleukin-20 receptor IIinterleukin-20 receptor subunit beta | |
Modification date | 20141207 | |
dbXrefs | MIM : 605621 | |
HGNC : HGNC | ||
Ensembl : ENSG00000174564 | ||
HPRD : 14594 | ||
Vega : OTTHUMG00000159779 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IL20RB | |
BioGPS: 53833 | ||
Pathway | NCI Pathway Interaction Database: IL20RB | |
KEGG: IL20RB | ||
REACTOME: IL20RB | ||
Pathway Commons: IL20RB | ||
Context | iHOP: IL20RB | |
ligand binding site mutation search in PubMed: IL20RB | ||
UCL Cancer Institute: IL20RB | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixSkin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCSKCM | |
Reference showing the relevant tissue of IL20RB | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for IL20RB |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | -0.338779857 | -2.405873607 | 2.06709375 | 1.25E-07 | 7.41E-07 |
KIRC | 2.122255907 | -2.427339926 | 4.549595833 | 9.54E-20 | 7.30E-19 |
LUAD | 1.17032176 | -1.07964893 | 2.24997069 | 1.12E-08 | 4.98E-08 |
LUSC | 3.54898295 | -0.752301364 | 4.301284314 | 1.20E-17 | 1.04E-16 |
LIHC | -0.344869482 | 0.678022518 | -1.022892 | 0.00363 | 0.008659753 |
PRAD | -1.298470482 | -0.04855702 | -1.249913462 | 2.69E-05 | 0.000131622 |
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TissGene-miRNA for IL20RB |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for IL20RB |
TissGeneSNV for IL20RB |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A217T | UCEC | 1 |
p.W170C | BLCA | 1 |
p.E291* | LUAD | 1 |
p.S286I | ESCA | 1 |
p.N47S | BLCA | 1 |
p.V43A | UCEC | 1 |
p.E144D | CESC | 1 |
p.D293Y | ACC | 1 |
p.E75D | LUAD | 1 |
p.N47D | STAD | 1 |
p.A217T | LUSC | 1 |
p.R214G | LIHC | 1 |
p.P85S | SARC | 1 |
p.D293A | ACC | 1 |
p.V113A | UCEC | 1 |
p.I145T | OV | 1 |
p.P60L | SKCM | 1 |
p.Y201H | KIRC | 1 |
p.E93D | STAD | 1 |
p.P25L | SKCM | 1 |
p.S311L | SKCM | 1 |
p.E75K | ACC | 1 |
p.S280L | SKCM | 1 |
p.D148N | HNSC | 1 |
p.T297M | PRAD | 1 |
p.L28F | STAD | 1 |
p.H129R | LUAD | 1 |
p.W255X | SKCM | 1 |
p.W255* | SKCM | 1 |
p.Q39H | PRAD | 1 |
p.V270I | LUAD | 1 |
p.Q71R | STAD | 1 |
p.E164Q | HNSC | 1 |
p.A50T | UCEC | 1 |
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TissGeneCNV for IL20RB |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IL20RB |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | SARC | TCGA-IF-A4AJ-01A | NCK1-IL20RB | In-Frame | chr3:136647069 | chr3:136708282 |
Chimerdb3.0 | FusionScan | PCPG | TCGA-QR-A70P-01A | NCK1-IL20RB | In-Frame | chr3:136647069 | chr3:136699307 |
Chimerdb3.0 | FusionScan | LGG | TCGA-CS-4938-01B | NCK1-IL20RB | In-Frame | chr3:136647069 | chr3:136708282 |
Chimerdb3.0 | FusionScan | LGG | TCGA-HT-7695-01A | NCK1-IL20RB | In-Frame | chr3:136647069 | chr3:136708282 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-AN-A03Y-01A | NCK1-IL20RB | In-Frame | chr3:136647069 | chr3:136708282 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-R6-A8W5-01B | NCK1-IL20RB | In-Frame | chr3:136647069 | chr3:136708282 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-IG-A51D-01A | NCK1-IL20RB | In-Frame | chr3:136647069 | chr3:136699307 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OS-01A | NCK1-IL20RB | In-Frame | chr3:136665137 | chr3:136728954 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-V5-A7RC-06A | NCK1-IL20RB | In-Frame | chr3:136647069 | chr3:136699307 |
Chimerdb3.0 | FusionScan | LUAD | TCGA-80-5611-01A | NCK1-IL20RB | In-Frame | chr3:136647069 | chr3:136699307 |
TCGAfusionPortal | PRADA | HNSC | TCGA-BA-6871-01A | IL20RB-NR4A1 | CDS-5UTR | Chr3:136677043 | Chr12:52448111 |
TCGAfusionPortal | PRADA | HNSC | TCGA-CX-7086-01A | IL20RB-NCK1 | CDS-5UTR | Chr3:136714398 | Chr3:136646826 |
TCGAfusionPortal | PRADA | LUSC | TCGA-22-5489-01A | CRYBG3-IL20RB | In-frame | Chr3:97600063 | Chr3:136728955 |
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TissGeneNet for IL20RB |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IL20RB |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IL20RB |
TissGeneDrug for IL20RB |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IL20RB |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0033860 | Psoriasis | 2 | BeFree,GAD,LHGDN |
umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |