TissGeneSummary for SLCO1C1 |
Gene summary |
Basic gene information | Gene symbol | SLCO1C1 |
Gene name | solute carrier organic anion transporter family, member 1C1 | |
Synonyms | OATP-F|OATP1|OATP14|OATP1C1|OATPF|OATPRP5|SLC21A14 | |
Cytomap | UCSC genome browser: 12p12.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001145944.1, NM_001145945.1,NM_001145946.1,NM_017435.4, | |
Description | OAT-RP-5OATP-14organic anion transporter Forganic anion transporter polypeptide-related protein 5organic anion transporting polypeptide 14organic anion-transporting polypeptide 14solute carrier family 21 (organic anion transporter), member 14solute | |
Modification date | 20141207 | |
dbXrefs | MIM : 613389 | |
HGNC : HGNC | ||
Ensembl : ENSG00000139155 | ||
HPRD : 08342 | ||
Vega : OTTHUMG00000168966 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLCO1C1 | |
BioGPS: 53919 | ||
Pathway | NCI Pathway Interaction Database: SLCO1C1 | |
KEGG: SLCO1C1 | ||
REACTOME: SLCO1C1 | ||
Pathway Commons: SLCO1C1 | ||
Context | iHOP: SLCO1C1 | |
ligand binding site mutation search in PubMed: SLCO1C1 | ||
UCL Cancer Institute: SLCO1C1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of SLCO1C1 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLCO1C1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -2.012617178 | -0.777647947 | -1.234969231 | 1.77E-06 | 9.44E-06 |
LIHC | -1.242238101 | -3.108606101 | 1.866368 | 1.47E-16 | 6.28E-15 |
KIRC | 0.568618399 | -1.35514549 | 1.923763889 | 6.27E-19 | 4.45E-18 |
LUSC | -2.029419591 | -0.958903905 | -1.070515686 | 1.04E-10 | 3.92E-10 |
BRCA | -1.284241469 | 0.386708531 | -1.67095 | 3.30E-20 | 2.38E-19 |
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TissGene-miRNA for SLCO1C1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLCO1C1 |
TissGeneSNV for SLCO1C1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S315F | SKCM | 2 |
p.S566F | SKCM | 2 |
p.Q269H | LUAD | 2 |
p.G620R | SKCM | 2 |
p.K708T | STAD | 2 |
p.S362R | HNSC | 2 |
p.S100R | ESCA | 1 |
p.D320N | KIRC | 1 |
p.R479T | HNSC | 1 |
p.R627S | OV | 1 |
p.L599I | UCEC | 1 |
p.R197C | LUSC | 1 |
p.P206L | SKCM | 1 |
p.A127G | LUSC | 1 |
p.S420I | LUAD | 1 |
p.I537T | HNSC | 1 |
p.P582Q | LUAD | 1 |
p.R73M | LUSC | 1 |
p.D85Y | LUSC | 1 |
p.S441F | SKCM | 1 |
p.R73M | STAD | 1 |
p.E713K | UCEC | 1 |
p.G707S | BRCA | 1 |
p.G82V | UCEC | 1 |
p.I642M | HNSC | 1 |
p.L279V | LUAD | 1 |
p.T497K | OV | 1 |
p.S431L | SKCM | 1 |
p.F131L | READ | 1 |
p.L125F | LIHC | 1 |
p.G410W | HNSC | 1 |
p.G725E | SKCM | 1 |
p.C480Y | OV | 1 |
p.S311F | SKCM | 1 |
p.G113R | SKCM | 1 |
p.D320G | KIRC | 1 |
p.P723S | SARC | 1 |
p.G446A | OV | 1 |
p.K426E | LIHC | 1 |
p.S670* | UCS | 1 |
p.H468N | BLCA | 1 |
p.C246Y | OV | 1 |
p.S184C | CESC | 1 |
p.G620E | SKCM | 1 |
p.S535L | LUAD | 1 |
p.R197C | SKCM | 1 |
p.S674R | STAD | 1 |
p.M336L | BLCA | 1 |
p.E488K | SKCM | 1 |
p.Y675H | THYM | 1 |
p.A471S | LUAD | 1 |
p.L617P | LIHC | 1 |
p.G282V | BLCA | 1 |
p.S629L | SKCM | 1 |
p.A391D | ESCA | 1 |
p.L611F | STAD | 1 |
p.R627T | ESCA | 1 |
p.A216T | STAD | 1 |
p.P265T | LUSC | 1 |
p.V499A | STAD | 1 |
p.R305K | STAD | 1 |
p.G122R | SKCM | 1 |
p.I722F | SKCM | 1 |
p.P143T | COAD | 1 |
p.E33K | BRCA | 1 |
p.P19T | LIHC | 1 |
p.Q69H | CESC | 1 |
p.D252G | LGG | 1 |
p.K481N | OV | 1 |
p.Y53F | KIRC | 1 |
p.F240V | SKCM | 1 |
p.S389F | DLBC | 1 |
p.G61A | ESCA | 1 |
p.S79L | SKCM | 1 |
p.Y459N | ACC | 1 |
p.C506F | SARC | 1 |
p.G277A | ESCA | 1 |
p.D321Y | LUAD | 1 |
p.E337* | LUAD | 1 |
p.I209F | SKCM | 1 |
p.V166A | UCS | 1 |
p.G572R | LUAD | 1 |
p.V231F | BLCA | 1 |
p.K426Q | UCEC | 1 |
p.S566T | UCEC | 1 |
p.S302F | LUSC | 1 |
p.G198E | BLCA | 1 |
p.G532R | SKCM | 1 |
p.P19S | SKCM | 1 |
p.N309I | HNSC | 1 |
p.G411E | LUSC | 1 |
p.S170L | BLCA | 1 |
p.Y355D | LUSC | 1 |
p.R73S | PAAD | 1 |
p.S534F | SKCM | 1 |
p.L276R | STAD | 1 |
p.N510S | SKCM | 1 |
p.F132S | BLCA | 1 |
p.L106F | BRCA | 1 |
p.G644E | HNSC | 1 |
p.P344S | LUSC | 1 |
p.G122E | SKCM | 1 |
p.G625V | STAD | 1 |
p.S666L | SKCM | 1 |
p.R479X | KIRC | 1 |
p.H107Y | SKCM | 1 |
p.L442V | OV | 1 |
p.N92K | UCEC | 1 |
p.P153L | ACC | 1 |
p.D682Y | THYM | 1 |
p.T679N | STAD | 1 |
p.D85N | UCEC | 1 |
p.L195R | COAD | 1 |
p.G532V | LUAD | 1 |
p.L295* | LUAD | 1 |
p.G120R | SARC | 1 |
p.C13Y | THYM | 1 |
p.C227G | SKCM | 1 |
p.S562F | SKCM | 1 |
p.A588V | SKCM | 1 |
p.T485P | LUSC | 1 |
p.E7* | SKCM | 1 |
p.N510K | PRAD | 1 |
p.G193A | LUAD | 1 |
p.S531F | SKCM | 1 |
p.P268S | BLCA | 1 |
p.S431T | STAD | 1 |
p.G61C | DLBC | 1 |
p.G200E | SKCM | 1 |
p.A57T | UCEC | 1 |
p.M186I | THYM | 1 |
p.P153L | COAD | 1 |
p.E306K | SKCM | 1 |
p.G330R | SKCM | 1 |
p.A527E | LUSC | 1 |
p.R631I | ESCA | 1 |
p.C246X | PRAD | 1 |
p.P344S | SKCM | 1 |
p.G546E | SKCM | 1 |
p.E488* | LUAD | 1 |
p.D634N | SKCM | 1 |
p.E134D | COAD | 1 |
p.E700D | SARC | 1 |
p.E168G | PRAD | 1 |
p.P206L | HNSC | 1 |
p.V231F | LUAD | 1 |
p.S298G | STAD | 1 |
p.P571L | KIRC | 1 |
p.E7X | READ | 1 |
p.R631I | COAD | 1 |
p.E700* | UCEC | 1 |
p.E484D | BRCA | 1 |
p.K699N | LUSC | 1 |
p.F393V | ESCA | 1 |
p.E7G | SKCM | 1 |
p.A595S | UCEC | 1 |
p.K316R | ESCA | 1 |
p.W274C | HNSC | 1 |
p.G446C | ESCA | 1 |
p.S150R | HNSC | 1 |
p.P328S | SKCM | 1 |
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TissGeneCNV for SLCO1C1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLCO1C1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SLCO1C1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLCO1C1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLCO1C1 |
TissGeneDrug for SLCO1C1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLCO1C1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
umls:C0011570 | Mental Depression | 1 | BeFree,GAD |
umls:C0011581 | Depressive disorder | 1 | BeFree |
umls:C0015672 | Fatigue | 1 | BeFree |
umls:C0020676 | Hypothyroidism | 1 | BeFree |
umls:C0029456 | Osteoporosis | 1 | GAD |
umls:C0700502 | Acquired hypothyroidism | 1 | BeFree |