TissGeneSummary for PNLIP |
Gene summary |
Basic gene information | Gene symbol | PNLIP |
Gene name | pancreatic lipase | |
Synonyms | PL|PNLIPD|PTL | |
Cytomap | UCSC genome browser: 10q26.1 | |
Type of gene | protein-coding | |
RefGenes | NM_000936.2, | |
Description | pancreatic triacylglycerol lipasetriacylglycerol acylhydrolase | |
Modification date | 20141207 | |
dbXrefs | MIM : 246600 | |
HGNC : HGNC | ||
Ensembl : ENSG00000175535 | ||
HPRD : 02005 | ||
Vega : OTTHUMG00000019103 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PNLIP | |
BioGPS: 5406 | ||
Pathway | NCI Pathway Interaction Database: PNLIP | |
KEGG: PNLIP | ||
REACTOME: PNLIP | ||
Pathway Commons: PNLIP | ||
Context | iHOP: PNLIP | |
ligand binding site mutation search in PubMed: PNLIP | ||
UCL Cancer Institute: PNLIP | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
Reference showing the relevant tissue of PNLIP | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PNLIP |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for PNLIP |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PNLIP |
TissGeneSNV for PNLIP |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E457K | SKCM | 2 |
p.P245S | SKCM | 2 |
p.G157S | BRCA | 1 |
p.V249G | HNSC | 1 |
p.R23K | LUSC | 1 |
p.E402K | SKCM | 1 |
p.F215S | LIHC | 1 |
p.S8L | THYM | 1 |
p.P245L | SKCM | 1 |
p.N279Y | SKCM | 1 |
p.N401K | KIRC | 1 |
p.T87A | UCEC | 1 |
p.E250* | LUAD | 1 |
p.T221M | BLCA | 1 |
p.C20F | UCEC | 1 |
p.T37M | BRCA | 1 |
p.G16V | UCEC | 1 |
p.W33L | ACC | 1 |
p.T190A | LUAD | 1 |
p.S79T | LUSC | 1 |
p.W355S | LUAD | 1 |
p.L281V | BRCA | 1 |
p.G35R | SKCM | 1 |
p.T453I | BLCA | 1 |
p.T221K | LUAD | 1 |
p.R207Q | UVM | 1 |
p.R54C | HNSC | 1 |
p.G378R | CESC | 1 |
p.E22K | HNSC | 1 |
p.P245A | LUSC | 1 |
p.R23K | LUAD | 1 |
p.G378E | SKCM | 1 |
p.F89C | UCS | 1 |
p.P225L | CESC | 1 |
p.D212N | SKCM | 1 |
p.K444E | LUSC | 1 |
p.F297V | STAD | 1 |
p.K108* | LUAD | 1 |
p.G233* | LUAD | 1 |
p.D295E | ACC | 1 |
p.A71T | PRAD | 1 |
p.S360Y | LGG | 1 |
p.S304F | BLCA | 1 |
p.W419X | READ | 1 |
p.A328T | OV | 1 |
p.S350C | LUSC | 1 |
p.D337Y | ESCA | 1 |
p.D209N | SKCM | 1 |
p.L459M | HNSC | 1 |
p.D264Y | LUAD | 1 |
p.G267R | PRAD | 1 |
p.S28C | LUAD | 1 |
p.T335A | LUSC | 1 |
p.S135L | SKCM | 1 |
p.K366T | SKCM | 1 |
p.D50G | COAD | 1 |
p.T288N | LUAD | 1 |
p.K49R | BLCA | 1 |
p.A178V | UCEC | 1 |
p.G98E | ACC | 1 |
p.Q385* | PRAD | 1 |
p.F417L | LUSC | 1 |
p.S127Y | STAD | 1 |
p.K214* | LUSC | 1 |
p.T37M | PRAD | 1 |
p.E61Q | LUSC | 1 |
p.T453A | KIRC | 1 |
p.L152I | LUAD | 1 |
p.G16E | SKCM | 1 |
p.G319R | LUAD | 1 |
p.L460F | UCEC | 1 |
p.H92N | CESC | 1 |
p.R188H | READ | 1 |
p.L103M | PAAD | 1 |
p.G142A | LUAD | 1 |
p.T309N | LUSC | 1 |
p.D274H | LUAD | 1 |
p.R39I | STAD | 1 |
p.G319E | LUSC | 1 |
p.S434F | STAD | 1 |
p.R188C | STAD | 1 |
p.P197H | LUAD | 1 |
p.E387K | SKCM | 1 |
p.T87I | UCEC | 1 |
p.P40H | LUAD | 1 |
p.D337Y | KIRC | 1 |
p.K256* | SKCM | 1 |
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TissGeneCNV for PNLIP |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PNLIP |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BC015104 | PNLIP-CPB1 | chr10:118307949 | chr3:148558670 | |
Chimerdb3.0 | ChiTaRs | NA | W52671 | PNLIP-PNLIP | chr10:118318768 | chr10:118318753 |
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TissGeneNet for PNLIP |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PNLIP |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PNLIP |
TissGeneDrug for PNLIP |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PNLIP |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
umls:C0018889 | Helminthiasis | 1 | BeFree |
umls:C0024523 | Malabsorption Syndrome | 1 | BeFree |
umls:C0028754 | Obesity | 1 | RGD |
umls:C0030305 | Pancreatitis | 1 | BeFree |
umls:C0079772 | T-Cell Lymphoma | 1 | BeFree |
umls:C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 1 | BeFree |
umls:C0268240 | Pancreatic triacylglycerol lipase deficiency | 1 | BeFree |
umls:C0392788 | Nasal Type Extranodal NK/T-Cell Lymphoma | 1 | BeFree |
umls:C0558916 | Nasal and nasal-type NK/T-cell lymphoma | 1 | BeFree |
umls:C0268241 | Pancreatic colipase deficiency | 0 | ORPHANET |