TissGeneSummary for PNLIPRP1 |
Gene summary |
Basic gene information | Gene symbol | PNLIPRP1 |
Gene name | pancreatic lipase-related protein 1 | |
Synonyms | PLRP1 | |
Cytomap | UCSC genome browser: 10q25.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001303135.1, NM_006229.3, | |
Description | inactive pancreatic lipase-related protein 1 | |
Modification date | 20141220 | |
dbXrefs | MIM : 604422 | |
HGNC : HGNC | ||
Ensembl : ENSG00000187021 | ||
HPRD : 05109 | ||
Vega : OTTHUMG00000019109 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PNLIPRP1 | |
BioGPS: 5407 | ||
Pathway | NCI Pathway Interaction Database: PNLIPRP1 | |
KEGG: PNLIPRP1 | ||
REACTOME: PNLIPRP1 | ||
Pathway Commons: PNLIPRP1 | ||
Context | iHOP: PNLIPRP1 | |
ligand binding site mutation search in PubMed: PNLIPRP1 | ||
UCL Cancer Institute: PNLIPRP1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverPancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCPAAD | |
Reference showing the relevant tissue of PNLIPRP1 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PNLIPRP1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for PNLIPRP1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PNLIPRP1 |
TissGeneSNV for PNLIPRP1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G17E | SKCM | 1 |
p.E349D | LIHC | 1 |
p.C109S | PRAD | 1 |
p.D296N | LUAD | 1 |
p.P430L | LIHC | 1 |
p.P396S | SKCM | 1 |
p.T235M | HNSC | 1 |
p.N383Y | STAD | 1 |
p.V140M | LUSC | 1 |
p.P33H | HNSC | 1 |
p.A148S | LUSC | 1 |
p.K256N | HNSC | 1 |
p.S103N | SKCM | 1 |
p.R274W | UCS | 1 |
p.R90L | LIHC | 1 |
p.K431N | BLCA | 1 |
p.T235A | HNSC | 1 |
p.A198V | COAD | 1 |
p.G53R | SKCM | 1 |
p.W420* | LUAD | 1 |
p.G100R | LUSC | 1 |
p.A271V | CHOL | 1 |
p.P226L | SKCM | 1 |
p.P466S | STAD | 1 |
p.S261F | LUAD | 1 |
p.A271V | BRCA | 1 |
p.A148T | UCS | 1 |
p.G382R | SKCM | 1 |
p.P246H | LUAD | 1 |
p.L408P | LGG | 1 |
p.L45I | UCEC | 1 |
p.V123M | ESCA | 1 |
p.D218Y | LGG | 1 |
p.E205D | STAD | 1 |
p.G100V | LUSC | 1 |
p.A259V | UCEC | 1 |
p.D296N | SKCM | 1 |
p.R457L | ESCA | 1 |
p.S202I | BLCA | 1 |
p.L187M | LUAD | 1 |
p.V147M | BRCA | 1 |
p.E453K | SKCM | 1 |
p.H166Y | HNSC | 1 |
p.Q149H | BLCA | 1 |
p.E443Q | BLCA | 1 |
p.P161H | LUAD | 1 |
p.W270L | LUAD | 1 |
p.L231V | UCEC | 1 |
p.F96I | BLCA | 1 |
p.F343V | UCEC | 1 |
p.I121M | ESCA | 1 |
p.A131D | ACC | 1 |
p.T465M | UCEC | 1 |
p.T191K | OV | 1 |
p.Q320* | SKCM | 1 |
p.R117T | CESC | 1 |
p.D459N | LUAD | 1 |
p.W47* | SARC | 1 |
p.A15D | BLCA | 1 |
p.R40K | DLBC | 1 |
p.R141P | HNSC | 1 |
p.G442R | SKCM | 1 |
p.F230L | UCEC | 1 |
p.W356C | PRAD | 1 |
p.T460M | BRCA | 1 |
p.W270S | CESC | 1 |
p.Q341H | LUAD | 1 |
p.T191S | LUAD | 1 |
p.R274L | CESC | 1 |
p.G240S | SKCM | 1 |
p.L429F | SKCM | 1 |
p.C109Y | BRCA | 1 |
p.H327Y | STAD | 1 |
p.D107G | BLCA | 1 |
p.S159T | BLCA | 1 |
p.E205K | LUAD | 1 |
p.D215N | SKCM | 1 |
p.S73F | HNSC | 1 |
p.P323L | LUAD | 1 |
p.G36W | LUAD | 1 |
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TissGeneCNV for PNLIPRP1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PNLIPRP1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-86-8279-01A | KIAA1429-PNLIPRP1 | Out-of-frame | Chr8:95556055 | Chr10:118350642 |
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TissGeneNet for PNLIPRP1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PNLIPRP1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PNLIPRP1 |
TissGeneDrug for PNLIPRP1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PNLIPRP1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |