TissGeneSummary for PNMT |
Gene summary |
Basic gene information | Gene symbol | PNMT |
Gene name | phenylethanolamine N-methyltransferase | |
Synonyms | PENT|PNMTase | |
Cytomap | UCSC genome browser: 17q12 | |
Type of gene | protein-coding | |
RefGenes | NM_002686.4, NR_073461.1, | |
Description | noradrenaline N-methyltransferasephenylethanolamine N-methylase | |
Modification date | 20141207 | |
dbXrefs | MIM : 171190 | |
HGNC : HGNC | ||
HPRD : 07176 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PNMT | |
BioGPS: 5409 | ||
Pathway | NCI Pathway Interaction Database: PNMT | |
KEGG: PNMT | ||
REACTOME: PNMT | ||
Pathway Commons: PNMT | ||
Context | iHOP: PNMT | |
ligand binding site mutation search in PubMed: PNMT | ||
UCL Cancer Institute: PNMT | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Adrenal glandEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PCPG,ACCUVM | |
Reference showing the relevant tissue of PNMT | ||
Description by TissGene annotations | Fused withOncogene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PNMT |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | 0.655740995 | -1.752611548 | 2.408352542 | 4.78E-17 | 8.89E-16 |
PRAD | -2.062390524 | 1.302161399 | -3.364551923 | 1.67E-12 | 8.14E-11 |
KIRP | -3.360396293 | -0.087274418 | -3.273121875 | 2.71E-13 | 4.82E-12 |
KIRC | -3.322183793 | -0.372935182 | -2.949248611 | 1.48E-30 | 2.94E-29 |
LUAD | -1.580822155 | 0.35989681 | -1.940718966 | 2.39E-09 | 1.20E-08 |
LUSC | -2.157315901 | -0.04951198 | -2.107803922 | 2.76E-11 | 1.10E-10 |
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TissGene-miRNA for PNMT |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PNMT |
TissGeneSNV for PNMT |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.T203M | STAD | 2 |
p.R145C | STAD | 1 |
p.N9S | KIRP | 1 |
p.R33H | LUSC | 1 |
p.R145H | STAD | 1 |
p.P164H | COAD | 1 |
p.A260T | STAD | 1 |
p.A181V | STAD | 1 |
p.S220L | UCEC | 1 |
p.L262F | SKCM | 1 |
p.A149V | STAD | 1 |
p.L165P | LUAD | 1 |
p.P42L | SKCM | 1 |
p.R245H | STAD | 1 |
p.R145C | PRAD | 1 |
p.R240G | COAD | 1 |
p.Q278H | LUSC | 1 |
p.D199H | HNSC | 1 |
p.S92G | SKCM | 1 |
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TissGeneCNV for PNMT |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PNMT |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | CESC | TCGA-Q1-A73R-01A | ERBB2-PNMT | 5'UTR-CDS | chr17:37851434 | chr17:37825881 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-B6-A0I9-01A | ASTN2-PNMT | Out-of-Frame | chr9:120053604 | chr17:37825881 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-3C-AALI-01A | IKZF3-PNMT | In-Frame | chr17:38020372 | chr17:37825881 |
Chimerdb3.0 | TopHat-Fusion | CESC | TCGA-Q1-A73R-01A | TCAP-PNMT | Out-of-Frame | chr17:37821620 | chr17:37825881 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-B6-A0I9-01A | ASTN2-PNMT | Out-of-Frame | chr9:120053604 | chr17:37825881 |
TCGAfusionPortal | PRADA | BRCA | TCGA-B6-A0I9-01A | ASTN2-PNMT | Out-of-frame | Chr9:120053605 | Chr17:37825882 |
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TissGeneNet for PNMT |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PNMT |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PNMT |
TissGeneDrug for PNMT |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PNMT |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020538 | Hypertensive disease | 6 | BeFree,GAD,LHGDN,RGD |
umls:C0031511 | Pheochromocytoma | 5 | BeFree |
umls:C0019562 | Von Hippel-Lindau Syndrome | 2 | BeFree |
umls:C0025268 | Multiple Endocrine Neoplasia Type 2a | 2 | BeFree |
umls:C0085580 | Essential Hypertension | 2 | BeFree |
umls:C1263846 | Attention deficit hyperactivity disorder | 2 | GAD |
umls:C0002395 | Alzheimer's Disease | 1 | BeFree,GAD |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
umls:C0020615 | Hypoglycemia | 1 | RGD |
umls:C0022660 | Kidney Failure, Acute | 1 | BeFree,GAD |
umls:C0026769 | Multiple Sclerosis | 1 | BeFree,GAD,LHGDN |
umls:C0027051 | Myocardial Infarction | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree,GAD |
umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
umls:C0264716 | Chronic heart failure | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C0856742 | Post MI | 1 | BeFree |
umls:C2911645 | Weight Loss Adverse Event | 1 | GAD |