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| TissGeneSummary for FAM3B |
 Gene summary |
| Basic gene information | Gene symbol | FAM3B |
| Gene name | family with sequence similarity 3, member B | |
| Synonyms | 2-21|C21orf11|C21orf76|ORF9|PANDER | |
| Cytomap | UCSC genome browser: 21q22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_058186.3, NM_206964.1, | |
| Description | D21M16SJHU19ecytokine-like protein 2-21pancreatic derived factorpancreatic-derived factorprotein FAM3B | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608617 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000183844 | ||
| HPRD : 10552 | ||
| Vega : OTTHUMG00000086752 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FAM3B | |
| BioGPS: 54097 | ||
| Pathway | NCI Pathway Interaction Database: FAM3B | |
| KEGG: FAM3B | ||
| REACTOME: FAM3B | ||
| Pathway Commons: FAM3B | ||
| Context | iHOP: FAM3B | |
| ligand binding site mutation search in PubMed: FAM3B | ||
| UCL Cancer Institute: FAM3B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADSTAD | |
| Reference showing the relevant tissue of FAM3B | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0030073 | insulin secretion | 12160727 | GO:0030073 | insulin secretion | 12160727 |
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| TissGeneExp for FAM3B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -0.447501793 | 1.351272768 | -1.798774561 | 3.04E-08 | 9.60E-08 |
| THCA | -0.72639595 | 1.56370744 | -2.29010339 | 6.06E-16 | 9.52E-15 |
| LUSC | -0.093349523 | 1.963775968 | -2.05712549 | 2.12E-06 | 5.11E-06 |
| HNSC | -1.895974192 | 4.002260692 | -5.898234884 | 1.77E-17 | 4.43E-15 |
| KIRP | -2.942879425 | 2.827117451 | -5.769996875 | 1.57E-13 | 2.95E-12 |
| KIRC | -3.417436369 | 2.803594187 | -6.221030556 | 2.02E-43 | 1.05E-41 |
| COAD | 1.004826345 | -1.314158271 | 2.318984615 | 0.00841 | 0.0190158 |
| KICH | 0.651059575 | 3.145831576 | -2.494772 | 0.000245 | 0.000595347 |
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| TissGene-miRNA for FAM3B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FAM3B |
| TissGeneSNV for FAM3B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G87E | SKCM | 1 |
| p.A206V | LUAD | 1 |
| p.A145V | UCEC | 1 |
| p.A106S | THYM | 1 |
| p.P238S | SKCM | 1 |
| p.G198R | SKCM | 1 |
| p.S80G | HNSC | 1 |
| p.C20F | HNSC | 1 |
| p.R84C | LGG | 1 |
| p.G87R | SKCM | 1 |
| p.T73S | STAD | 1 |
| p.N110S | UCEC | 1 |
| p.C59F | HNSC | 1 |
| p.G120R | SKCM | 1 |
| p.S239F | SKCM | 1 |
| p.G6R | SKCM | 1 |
| p.F190C | UCS | 1 |
| p.E217* | HNSC | 1 |
| p.G147V | SKCM | 1 |
| p.D34G | UCEC | 1 |
| p.N203S | LUAD | 1 |
| p.D7N | SKCM | 1 |
| p.R45H | STAD | 1 |
| p.F229C | UCS | 1 |
| p.A162S | HNSC | 1 |
| p.S200F | SKCM | 1 |
| p.E240K | SKCM | 1 |
| p.A167G | LUSC | 1 |
| p.G81R | SKCM | 1 |
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| TissGeneCNV for FAM3B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FAM3B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | CESC | TCGA-VS-A8EJ-01A | BACE2-FAM3B | In-Frame | chr21:42629253 | chr21:42710304 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A0B9-01A | BACE2-FAM3B | In-Frame | chr21:42629253 | chr21:42710304 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-V5-A7RB-01A | BACE2-FAM3B | In-Frame | chr21:42629253 | chr21:42710304 |
| Chimerdb3.0 | FusionScan | OV | TCGA-VG-A8LO-01A | BACE2-FAM3B | In-Frame | chr21:42629253 | chr21:42710304 |
| TCGAfusionPortal | PRADA | LUSC | TCGA-37-3792-01A | MORC3-FAM3B | Out-of-frame | Chr21:37744829 | Chr21:42710305 |
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| TissGeneNet for FAM3B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for FAM3B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FAM3B |
| TissGeneDrug for FAM3B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FAM3B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0020456 | Hyperglycemia | 2 | BeFree |
| umls:C0740380 | Varicella zoster | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0013080 | Down Syndrome | 1 | CTD_human |
| umls:C0015695 | Fatty Liver | 1 | BeFree |
| umls:C0018798 | Congenital Heart Defects | 1 | BeFree |
| umls:C0024198 | Lyme Disease | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0037278 | Skin Diseases, Infectious | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0041107 | Trisomy | 1 | BeFree |
| umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
| umls:C0151786 | Muscle Weakness | 1 | CTD_human |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | BeFree |
| umls:C0586989 | Varicella-zoster virus infection | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C1319315 | Adenocarcinoma of large intestine | 1 | BeFree |
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