TissGeneSummary for SNTG2 |
Gene summary |
Basic gene information | Gene symbol | SNTG2 |
Gene name | syntrophin, gamma 2 | |
Synonyms | G2SYN|SYN5 | |
Cytomap | UCSC genome browser: 2p25.3 | |
Type of gene | protein-coding | |
RefGenes | NM_018968.3, | |
Description | gamma-2-syntrophinsyntrophin-5 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608715 | |
HGNC : HGNC | ||
Ensembl : ENSG00000172554 | ||
HPRD : 16374 | ||
Vega : OTTHUMG00000151370 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SNTG2 | |
BioGPS: 54221 | ||
Pathway | NCI Pathway Interaction Database: SNTG2 | |
KEGG: SNTG2 | ||
REACTOME: SNTG2 | ||
Pathway Commons: SNTG2 | ||
Context | iHOP: SNTG2 | |
ligand binding site mutation search in PubMed: SNTG2 | ||
UCL Cancer Institute: SNTG2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SNTG2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SNTG2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -1.027622582 | 0.40001588 | -1.427638462 | 2.53E-10 | 3.22E-09 |
HNSC | -0.273565247 | 1.043599869 | -1.317165116 | 2.26E-06 | 1.55E-05 |
THCA | 0.377252451 | 1.490067705 | -1.112815254 | 3.29E-08 | 1.52E-07 |
BRCA | -0.341054701 | 2.358961966 | -2.700016667 | 6.62E-37 | 1.41E-35 |
ESCA | -0.501773281 | 0.944690355 | -1.446463636 | 0.00427 | 0.035650637 |
BLCA | -0.785087157 | 0.837260212 | -1.622347368 | 2.05E-05 | 0.0003296 |
STAD | -0.695503111 | 0.616181264 | -1.311684375 | 1.59E-05 | 0.000167883 |
KICH | -1.012170736 | 0.256053264 | -1.268224 | 5.54E-05 | 0.000152627 |
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TissGene-miRNA for SNTG2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SNTG2 |
TissGeneSNV for SNTG2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G192E | SKCM | 3 |
p.S204L | SKCM | 2 |
p.P334S | SKCM | 2 |
p.P293S | SKCM | 2 |
p.W412* | SKCM | 2 |
p.G192R | SKCM | 1 |
p.N283S | STAD | 1 |
p.E352D | THYM | 1 |
p.L239I | ESCA | 1 |
p.A108E | LUAD | 1 |
p.F416I | HNSC | 1 |
p.D218E | LUSC | 1 |
p.L372V | STAD | 1 |
p.S65N | UCEC | 1 |
p.S37T | STAD | 1 |
p.W341G | HNSC | 1 |
p.T25M | BRCA | 1 |
p.S200L | STAD | 1 |
p.R426K | CESC | 1 |
p.G428W | STAD | 1 |
p.S101L | SKCM | 1 |
p.E105* | BLCA | 1 |
p.Q377H | ESCA | 1 |
p.G394D | UCEC | 1 |
p.D378N | SKCM | 1 |
p.N70_splice | OV | 1 |
p.S180P | LIHC | 1 |
p.E245K | SKCM | 1 |
p.Q55H | HNSC | 1 |
p.T420M | READ | 1 |
p.V392M | GBM | 1 |
p.S221F | SKCM | 1 |
p.H128P | LUAD | 1 |
p.T28N | ESCA | 1 |
p.E147K | SKCM | 1 |
p.A310T | SKCM | 1 |
p.W367* | UCEC | 1 |
p.T236M | LUSC | 1 |
p.G68D | COAD | 1 |
p.K397N | BLCA | 1 |
p.D42N | SKCM | 1 |
p.E382Q | HNSC | 1 |
p.E499G | ESCA | 1 |
p.D295N | PAAD | 1 |
p.W361* | UCEC | 1 |
p.A158V | BRCA | 1 |
p.R231K | LUAD | 1 |
p.T420M | GBM | 1 |
p.W302L | LUSC | 1 |
p.L531P | ESCA | 1 |
p.R71H | STAD | 1 |
p.A271V | HNSC | 1 |
p.A448T | COAD | 1 |
p.L368V | STAD | 1 |
p.A505S | ESCA | 1 |
p.R258Q | READ | 1 |
p.G187S | GBM | 1 |
p.S200L | SKCM | 1 |
p.D311N | HNSC | 1 |
p.N304I | UCEC | 1 |
p.S313A | BRCA | 1 |
p.M411I | UCEC | 1 |
p.Q107E | LUAD | 1 |
p.A243T | LGG | 1 |
p.Q369X | COAD | 1 |
p.V99I | STAD | 1 |
p.I29V | BLCA | 1 |
p.R215H | SARC | 1 |
p.R385S | LUAD | 1 |
p.R77C | LIHC | 1 |
p.G192E | LUAD | 1 |
p.G126D | PRAD | 1 |
p.T236K | LIHC | 1 |
p.H349D | BLCA | 1 |
p.R258W | COAD | 1 |
p.E423K | SKCM | 1 |
p.N275Y | KIRP | 1 |
p.W241* | SKCM | 1 |
p.P334H | COAD | 1 |
p.V62L | LIHC | 1 |
p.E136Q | LUAD | 1 |
p.E382K | CESC | 1 |
p.E237K | SKCM | 1 |
p.E382G | READ | 1 |
p.A410S | LUAD | 1 |
p.V138_splice | LUSC | 1 |
p.M300I | BLCA | 1 |
p.G309E | CESC | 1 |
p.G192R | UCEC | 1 |
p.N191K | LUAD | 1 |
p.L257P | STAD | 1 |
p.T347I | SKCM | 1 |
p.L372M | STAD | 1 |
p.C290Y | SKCM | 1 |
p.E494D | UCEC | 1 |
p.S530I | LIHC | 1 |
p.T261R | LIHC | 1 |
p.G265V | LIHC | 1 |
p.G406D | STAD | 1 |
p.P334L | SKCM | 1 |
p.E147K | LUSC | 1 |
p.S435N | ESCA | 1 |
p.E105K | SKCM | 1 |
p.I276M | LUAD | 1 |
p.P182L | SKCM | 1 |
p.H349Y | LUAD | 1 |
p.I43M | BLCA | 1 |
p.S172F | SKCM | 1 |
p.S172T | LUSC | 1 |
p.W302C | LUAD | 1 |
p.S180P | LUAD | 1 |
p.D365Y | ESCA | 1 |
p.A227T | SKCM | 1 |
p.K89E | LUAD | 1 |
p.R385K | SKCM | 1 |
p.I127T | BLCA | 1 |
p.E408K | COAD | 1 |
p.P293L | SKCM | 1 |
p.R343Q | UCS | 1 |
p.E305Q | LUAD | 1 |
p.L323M | LUAD | 1 |
p.L47V | LGG | 1 |
p.S177I | PRAD | 1 |
p.A248T | COAD | 1 |
p.D295N | SKCM | 1 |
p.R72I | UCEC | 1 |
p.G255E | SKCM | 1 |
p.W341C | LUSC | 1 |
p.R142I | UCEC | 1 |
p.Y329* | LUAD | 1 |
p.R258W | STAD | 1 |
p.R71C | UCEC | 1 |
p.R77H | UCEC | 1 |
p.V74A | LUAD | 1 |
p.H349Y | SKCM | 1 |
p.E408K | SKCM | 1 |
p.D380H | CESC | 1 |
p.P210L | LGG | 1 |
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TissGeneCNV for SNTG2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SNTG2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AA451832 | SNTG2-GCLM | chr2:1064058 | chr1:94353207 | |
Chimerdb3.0 | ChiTaRs | NA | BX493397 | SNTG2-CCDC88A | chr2:1352674 | chr2:55562168 | |
Chimerdb3.0 | ChiTaRs | NA | T07088 | ATG9A-SNTG2 | chr2:220088872 | chr2:1182673 | |
Chimerdb3.0 | ChiTaRs | NA | CB241959 | TGS1-SNTG2 | chr8:56698841 | chr2:992480 | |
Chimerdb3.0 | FusionScan | PRAD | TCGA-J4-A83J-01A | WWC1-SNTG2 | Out-of-Frame | chr5:167841595 | chr2:1161233 |
TCGAfusionPortal | PRADA | PRAD | TCGA-J4-A83J-01A | WWC1-SNTG2 | Out-of-frame | Chr5:167841595 | Chr2:1161234 |
TCGAfusionPortal | PRADA | PRAD | TCGA-TK-A8OK-01A | AFF4-SNTG2 | In-frame | Chr5:132227856 | Chr2:1204789 |
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TissGeneNet for SNTG2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SNTG2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SNTG2 |
TissGeneDrug for SNTG2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SNTG2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004352 | Autistic Disorder | 1 | BeFree,CTD_human |
umls:C0008074 | Child Development Disorders, Pervasive | 1 | CTD_human |