TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PON1

Gene summary

Basic gene information	Gene symbol	PON1
	Gene name	paraoxonase 1
	Synonyms	ESA\|MVCD5\|PON
	Cytomap	UCSC genome browser: 7q21.3
	Type of gene	protein-coding
	RefGenes	NM_000446.5,
	Description	A-esterase 1K-45PON 1aromatic esterase 1arylesterase 1arylesterase B-typeesterase Aparaoxonase B-typeserum aryldiakylphosphataseserum aryldialkylphosphatase 1serum paraoxonase/arylesterase 1
	Modification date	20141222
dbXrefs	MIM : 168820
	HGNC : HGNC
	HPRD : 01351
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PON1
	BioGPS: 5444
Pathway	NCI Pathway Interaction Database: PON1
	KEGG: PON1
	REACTOME: PON1
	Pathway Commons: PON1
Context	iHOP: PON1
	ligand binding site mutation search in PubMed: PON1
	UCL Cancer Institute: PON1
Assigned class in TissGDB*	A
Included tissue-specific gene expression resources	HPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LIHC
Reference showing the relevant tissue of PON1	Effect of Inorganic Dietary Selenium Supplementation on Selenoprotein and Lipid Metabolism Gene Expression Patterns in Liver and Loin Muscle of Growing Lambs. Juszczuk-Kubiak E, Bujko K, Cymer M, Wicińska K, Gabryszuk M, Pierzchała M. Biol Trace Elem Res. 2016 Aug;172(2):336-45. doi: 10.1007/s12011-015-0592-0. Epub 2015 Dec 23. (pmid:26701332) go to article
Description by TissGene annotations	Cancer gene Significant down-regulated DEG Have significant anti-correlated miRNA TissgsKTS CNV lost TissGeneKTS

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0010875	positive regulation of cholesterol efflux	15721011
GO:0016311	dephosphorylation	15098021
GO:0019439	aromatic compound catabolic process	15772423
GO:0032411	positive regulation of transporter activity	15721011
GO:0034445	negative regulation of plasma lipoprotein particle oxidation	15342686
GO:0046395	carboxylic acid catabolic process	7638166
GO:0046434	organophosphate catabolic process	7638166
GO:0046470	phosphatidylcholine metabolic process	15721011
GO:0051099	positive regulation of binding	15721011
GO:0010875	positive regulation of cholesterol efflux	15721011
GO:0016311	dephosphorylation	15098021
GO:0019439	aromatic compound catabolic process	15772423
GO:0032411	positive regulation of transporter activity	15721011
GO:0034445	negative regulation of plasma lipoprotein particle oxidation	15342686
GO:0046395	carboxylic acid catabolic process	7638166
GO:0046434	organophosphate catabolic process	7638166
GO:0046470	phosphatidylcholine metabolic process	15721011
GO:0051099	positive regulation of binding	15721011

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TissGeneExp for PON1

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
LUSC	-1.170424029	-0.059429911	-1.110994118	3.31E-05	7.18E-05
KIRC	-2.213561529	-0.735364307	-1.478197222	1.18E-10	4.16E-10
KIRP	-2.386072987	-0.469379237	-1.91669375	5.53E-07	2.98E-06
KICH	-2.492893362	-0.967569362	-1.525324	6.27E-06	2.06E-05
LIHC	9.636154638	11.59043064	-1.954276	3.95E-06	1.87E-05
STAD	-0.266035487	-1.783738612	1.517703125	0.00802	0.028905417
PRAD	-1.046051593	0.150854176	-1.196905769	0.00456	0.011980023

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TissGene-miRNA for PON1

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type	miRNA id	miRNA accession	P-val.	Coeff.	# samples
UCS	hsa-miR-26a-5p	MIMAT0000082	0.024	-0.3	56

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TissGeneMut for PON1

TissGeneSNV for PON1

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.R306Q	UCEC	3
p.R32*	BLCA	2
p.G61R	SKCM	2
p.R306Q	COAD	1
p.W254X	SKCM	1
p.G2R	SKCM	1
p.W281*	SKCM	1
p.L191F	LUSC	1
p.D251N	LUSC	1
p.T8S	DLBC	1
p.H43L	LIHC	1
p.A63T	UCEC	1
p.F146V	PRAD	1
p.R306Q	READ	1
p.W202C	SARC	1
p.L143S	LUAD	1
p.E33D	ESCA	1
p.R306X	SKCM	1
p.L14M	STAD	1
p.W254*	SKCM	1
p.R27*	LUSC	1
p.E323D	SKCM	1
p.R27S	LUAD	1
p.I226F	LUSC	1
p.V317A	UCEC	1
p.H348Y	SKCM	1
p.P79S	SKCM	1
p.A2V	STAD	1
p.T8I	SKCM	1
p.G68E	SKCM	1
p.I245M	ESCA	1
p.G283A	HNSC	1
p.V268M	UCEC	1
p.D274E	KIRP	1
p.P230H	LUSC	1
p.V5A	CESC	1
p.R32*	SKCM	1
p.D231N	COAD	1
p.A15T	UCEC	1
p.H246Y	SKCM	1
p.D231N	SKCM	1
p.L187P	STAD	1
p.N41Y	STAD	1
p.I5T	SKCM	1
p.R27*	LGG	1
p.C284S	HNSC	1
p.Y24*	HNSC	1
p.M88I	STAD	1
p.N298Y	GBM	1
p.L48R	STAD	1
p.G11W	GBM	1
p.E297D	UCEC	1
p.K145N	PAAD	1
p.K151T	UCEC	1
p.L9F	SKCM	1
p.R306*	SKCM	1
p.I291L	UCEC	1
p.W254R	LIHC	1
p.V215E	LUAD	1
p.S111*	BRCA	1
p.A242T	COAD	1
p.E239Q	BLCA	1
p.E92K	SKCM	1
p.E38*	UCEC	1
p.G232S	SKCM	1
p.L351V	BLCA	1
p.R27X	COAD	1
p.L87Q	SKCM	1
p.E123K	SKCM	1
p.Q329*	LUAD	1
p.G2A	LUSC	1
p.N253D	KICH	1
p.R315M	UCEC	1
p.S152L	BLCA	1
p.K70N	BLCA	1
p.R32Q	KICH	1
p.M127R	DLBC	1
p.L280I	LUSC	1
p.D269N	SKCM	1
p.R32*	UCEC	1
p.L280H	LUSC	1
p.G47E	SKCM	1
p.M88I	SKCM	1
p.N60T	HNSC	1
p.Y337C	UCEC	1

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TissGeneCNV for PON1

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for PON1

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	BX485261	UBE2H-PON1		chr7:129503432	chr7:94929189

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TissGeneNet for PON1

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (tumor)	PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (normal)

COAD (tumor)	COAD (normal)
PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (tumor)	PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (normal)

HNSC (tumor)	HNSC (normal)
PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (tumor)	PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (normal)

KICH (tumor)	KICH (normal)
PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (tumor)	PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (normal)

KIRC (tumor)	KIRC (normal)
PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (tumor)	PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (normal)

KIRP (tumor)	KIRP (normal)
PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (tumor)	PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (normal)

LIHC (tumor)	LIHC (normal)
PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (tumor)	PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (normal)

LUAD (tumor)	LUAD (normal)
PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (tumor)	PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (normal)

LUSC (tumor)	LUSC (normal)
PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (tumor)	PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (normal)

PRAD (tumor)	PRAD (normal)
PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (tumor)	PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (normal)

STAD (tumor)	STAD (normal)
PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (tumor)	PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (normal)

THCA (tumor)	THCA (normal)
PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (tumor)	PON1, HNF4A, ONECUT1, PITX3, ALB, APOA1, SUMO4, CLU (normal)

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TissGeneProg for PON1

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for PON1

TissGeneDrug for PON1

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID	Drug name	Drug activity	Drug type	Drug status
DB01327	Cefazolin	Inhibitor	Small molecule	Approved

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TissGeneDisease for PON1

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0004153	Atherosclerosis	116	BeFree,CTD_human,GAD,LHGDN
umls:C0003850	Arteriosclerosis	101	BeFree
umls:C0010068	Coronary heart disease	92	BeFree,CTD_human,GAD,LHGDN
umls:C0010054	Coronary Arteriosclerosis	85	BeFree,GAD
umls:C1956346	Coronary Artery Disease	68	BeFree,CTD_human,GAD,LHGDN
umls:C0007222	Cardiovascular Diseases	53	BeFree,CTD_human,GAD,LHGDN
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	40	BeFree,GAD,LHGDN
umls:C0038454	Cerebrovascular accident	31	BeFree,GAD,LHGDN
umls:C0011849	Diabetes Mellitus	30	BeFree,CTD_human,GAD,LHGDN
umls:C0027051	Myocardial Infarction	26	BeFree,GAD,LHGDN
umls:C0011847	Diabetes	20	BeFree
umls:C0042373	Vascular Diseases	18	BeFree,GAD
umls:C0002395	Alzheimer's Disease	16	BeFree,GAD,LHGDN
umls:C0948008	Ischemic stroke	15	BeFree,GAD
umls:C0002736	Amyotrophic Lateral Sclerosis	14	BeFree,GAD,LHGDN,ORPHANET
umls:C0020538	Hypertensive disease	14	BeFree,GAD,LHGDN
umls:C0028754	Obesity	14	BeFree,GAD
umls:C0006142	Malignant neoplasm of breast	12	BeFree,GAD
umls:C0678222	Breast Carcinoma	12	BeFree
umls:C3272363	Ischemic Cerebrovascular Accident	12	BeFree
umls:C0524620	Metabolic Syndrome X	11	BeFree,CTD_human,GAD
umls:C0030567	Parkinson Disease	10	BeFree,GAD,LHGDN
umls:C0003873	Rheumatoid Arthritis	9	BeFree,CTD_human,GAD,LHGDN
umls:C0242383	Age related macular degeneration	9	BeFree,GAD
umls:C0577631	Carotid Atherosclerosis	9	BeFree,GAD
umls:C0948089	Acute Coronary Syndrome	9	BeFree,CTD_human,GAD
umls:C0007273	Carotid Artery Diseases	8	BeFree,GAD
umls:C0011854	Diabetes Mellitus, Insulin-Dependent	8	BeFree,GAD
umls:C0020445	Hypercholesterolemia, Familial	8	BeFree,CTD_human,LHGDN
umls:C0700359	Organophosphate poisoning	8	CTD_human,GAD
umls:C0011884	Diabetic Retinopathy	7	BeFree,CTD_human,GAD
umls:C0021368	Inflammation	7	GAD,LHGDN
umls:C0032460	Polycystic Ovary Syndrome	7	BeFree,GAD,LHGDN
umls:C0007786	Brain Ischemia	6	GAD
umls:C0020443	Hypercholesterolemia	6	BeFree,CTD_human,GAD
umls:C0598608	Hyperhomocysteinemia	6	BeFree,CTD_human,GAD
umls:C0020473	Hyperlipidemia	5	BeFree,GAD,LHGDN
umls:C0022658	Kidney Diseases	5	BeFree,GAD
umls:C0024141	Lupus Erythematosus, Systemic	5	BeFree,GAD
umls:C0026769	Multiple Sclerosis	5	BeFree,GAD,LHGDN
umls:C0035309	Retinal Diseases	5	BeFree
umls:C0151526	Premature Birth	5	GAD
umls:C0151744	Myocardial Ischemia	5	BeFree,GAD
umls:C0282550	Persian Gulf Syndrome	5	BeFree,CTD_human
umls:C0376358	Malignant neoplasm of prostate	5	BeFree,GAD
umls:C0600139	Prostate carcinoma	5	BeFree
umls:C1862941	Amyotrophic Lateral Sclerosis, Sporadic	5	BeFree
umls:C0011269	Dementia, Vascular	4	BeFree,GAD,LHGDN
umls:C0011581	Depressive disorder	4	BeFree,CTD_human
umls:C0011881	Diabetic Nephropathy	4	BeFree,LHGDN
umls:C0012860	DNA Damage	4	GAD
umls:C0021364	Male infertility	4	BeFree,CTD_human
umls:C0022661	Kidney Failure, Chronic	4	BeFree,GAD,LHGDN
umls:C0032914	Pre-Eclampsia	4	GAD,LHGDN
umls:C0242231	Coronary Stenosis	4	BeFree,GAD
umls:C0403447	Chronic Kidney Insufficiency	4	BeFree
umls:C0525045	Mood Disorders	4	BeFree
umls:C0596263	Carcinogenesis	4	BeFree
umls:C1561643	Chronic Kidney Diseases	4	BeFree
umls:C0001828	Agricultural Workers' Diseases	3	CTD_human,GAD
umls:C0002871	Anemia	3	BeFree,LHGDN
umls:C0004352	Autistic Disorder	3	BeFree,CTD_human
umls:C0005283	beta Thalassemia	3	BeFree,LHGDN
umls:C0005586	Bipolar Disorder	3	BeFree
umls:C0006118	Brain Neoplasms	3	BeFree,CTD_human,GAD
umls:C0010346	Crohn Disease	3	BeFree,LHGDN
umls:C0011570	Mental Depression	3	BeFree,GAD
umls:C0017658	Glomerulonephritis	3	BeFree,GAD
umls:C0021655	Insulin Resistance	3	GAD
umls:C0023895	Liver diseases	3	BeFree,GAD,LHGDN
umls:C0024299	Lymphoma	3	BeFree,CTD_human
umls:C0029928	Ovarian Diseases	3	BeFree
umls:C0033578	Prostatic Neoplasms	3	CTD_human,LHGDN
umls:C0155626	Acute myocardial infarction	3	BeFree
umls:C0242379	Malignant neoplasm of lung	3	BeFree,GAD
umls:C0242606	Oxidative Stress	3	GAD
umls:C0242992	Multiple Chemical Sensitivity	3	GAD
umls:C0333186	Restenosis	3	BeFree,GAD
umls:C0497327	Dementia	3	BeFree,GAD,LHGDN
umls:C1527249	Colorectal Cancer	3	BeFree,GAD
umls:C3272265	Three Vessel Coronary Disease	3	BeFree
umls:C3714514	Infection	3	GAD,LHGDN
umls:C0002965	Angina, Unstable	2	BeFree
umls:C0002986	Fabry Disease	2	BeFree
umls:C0004096	Asthma	2	BeFree,GAD
umls:C0007137	Squamous cell carcinoma	2	BeFree
umls:C0007785	Cerebral Infarction	2	BeFree,GAD
umls:C0009324	Ulcerative Colitis	2	BeFree,LHGDN
umls:C0009402	Colorectal Carcinoma	2	BeFree
umls:C0010073	Coronary Artery Vasospasm	2	BeFree,CTD_human,GAD
umls:C0011265	Presenile dementia	2	BeFree
umls:C0011875	Diabetic Angiopathies	2	BeFree,GAD,LHGDN
umls:C0017327	Generalized atherosclerosis	2	GAD
umls:C0017668	Focal glomerulosclerosis	2	BeFree,GAD
umls:C0019189	Hepatitis, Chronic	2	BeFree
umls:C0019693	HIV Infections	2	BeFree
umls:C0019829	Hodgkin Disease	2	BeFree
umls:C0020179	Huntington Disease	2	BeFree
umls:C0020474	Hyperlipidemia, Familial Combined	2	BeFree,LHGDN
umls:C0020476	Hyperlipoproteinemias	2	CTD_human,RGD
umls:C0021390	Inflammatory Bowel Diseases	2	BeFree,LHGDN
umls:C0022116	Ischemia	2	BeFree,LHGDN
umls:C0023890	Liver Cirrhosis	2	BeFree
umls:C0024143	Lupus Nephritis	2	BeFree,GAD
umls:C0024305	Lymphoma, Non-Hodgkin	2	GAD
umls:C0024437	Macular degeneration	2	BeFree
umls:C0025286	Meningioma	2	BeFree,GAD
umls:C0029925	Ovarian Carcinoma	2	BeFree
umls:C0036341	Schizophrenia	2	BeFree,GAD
umls:C0085096	Peripheral Vascular Diseases	2	BeFree
umls:C0149931	Migraine Disorders	2	BeFree
umls:C0154251	Lipid Metabolism Disorders	2	BeFree,GAD
umls:C0162429	Malnutrition	2	BeFree
umls:C0206064	Microvascular Angina	2	BeFree
umls:C0220603	childhood brain tumor	2	GAD
umls:C0235031	Neurologic Symptoms	2	BeFree
umls:C0242339	Dyslipidemias	2	BeFree
umls:C0333497	Segmental glomerulosclerosis	2	BeFree
umls:C0342879	Primary hypercholesterolemia	2	BeFree
umls:C0524851	Neurodegenerative Disorders	2	BeFree
umls:C0684249	Carcinoma of lung	2	BeFree
umls:C0687132	heavy drinking	2	BeFree
umls:C0741923	cardiac event	2	BeFree
umls:C0856169	Endothelial dysfunction	2	BeFree
umls:C1140680	Malignant neoplasm of ovary	2	BeFree,GAD
umls:C1263846	Attention deficit hyperactivity disorder	2	BeFree
umls:C1510586	Autism Spectrum Disorders	2	BeFree
umls:C1704436	Peripheral Arterial Diseases	2	BeFree
umls:C2362324	Pediatric Obesity	2	BeFree
umls:C3495426	Homocysteinemia	2	BeFree
umls:C0000768	Congenital Abnormality	1	BeFree
umls:C0000786	Spontaneous abortion	1	GAD
umls:C0001627	Congenital adrenal hyperplasia	1	GAD
umls:C0001925	Albuminuria	1	GAD
umls:C0002962	Angina Pectoris	1	GAD
umls:C0003469	Anxiety Disorders	1	BeFree,GAD
umls:C0003860	Arteritis	1	CTD_human
umls:C0004114	Astrocytoma	1	BeFree,GAD
umls:C0005612	Birth Weight	1	CTD_human
umls:C0005684	Malignant neoplasm of urinary bladder	1	BeFree,GAD
umls:C0007124	Noninfiltrating Intraductal Carcinoma	1	BeFree
umls:C0007570	Celiac Disease	1	BeFree,LHGDN
umls:C0007771	Intracranial Arteriosclerosis	1	GAD
umls:C0007820	Cerebrovascular Disorders	1	GAD
umls:C0008495	Chorioamnionitis	1	GAD
umls:C0008924	Cleft Lip	1	GAD
umls:C0008925	Cleft Palate	1	GAD
umls:C0009319	Colitis	1	BeFree
umls:C0009782	Connective Tissue Diseases	1	GAD
umls:C0009806	Constipation	1	CTD_human
umls:C0010674	Cystic Fibrosis	1	BeFree
umls:C0014175	Endometriosis	1	LHGDN
umls:C0015929	Fetal Diseases	1	GAD
umls:C0015934	Fetal Growth Retardation	1	GAD
umls:C0015944	Fetal Membranes, Premature Rupture	1	GAD
umls:C0016059	Fibrosis	1	LHGDN
umls:C0017178	Gastrointestinal Diseases	1	BeFree
umls:C0017612	Glaucoma, Open-Angle	1	BeFree,LHGDN
umls:C0017661	IGA Glomerulonephritis	1	BeFree,GAD
umls:C0017662	Glomerulonephritis, Membranoproliferative	1	BeFree,CTD_human,LHGDN
umls:C0018671	Head and Neck Neoplasms	1	GAD
umls:C0019045	Hemoglobinopathies	1	BeFree
umls:C0019112	Hemorrhoids	1	BeFree,CTD_human
umls:C0019196	Hepatitis C	1	LHGDN
umls:C0020450	Hyperemesis Gravidarum	1	LHGDN
umls:C0020456	Hyperglycemia	1	LHGDN
umls:C0020550	Hyperthyroidism	1	CTD_human
umls:C0022876	Premature Obstetric Labor	1	GAD
umls:C0023418	leukemia	1	BeFree
umls:C0023467	Leukemia, Myelocytic, Acute	1	BeFree
umls:C0023903	Liver neoplasms	1	BeFree
umls:C0024117	Chronic Obstructive Airway Disease	1	BeFree
umls:C0024121	Lung Neoplasms	1	CTD_human
umls:C0025284	Meningeal Neoplasms	1	GAD
umls:C0025945	Microangiopathy, Diabetic	1	BeFree
umls:C0026636	Mouth Diseases	1	GAD
umls:C0026764	Multiple Myeloma	1	BeFree,GAD
umls:C0026857	Musculoskeletal Diseases	1	GAD
umls:C0027643	Neoplasm Recurrence, Local	1	GAD
umls:C0027654	Embryonal Neoplasm	1	BeFree
umls:C0027660	Neoplasms, Glandular and Epithelial	1	GAD
umls:C0027708	Nephroblastoma	1	BeFree
umls:C0028043	Nicotine Dependence	1	BeFree
umls:C0028797	Occupational Diseases	1	CTD_human
umls:C0029445	Bone necrosis	1	GAD,LHGDN
umls:C0030305	Pancreatitis	1	GAD
umls:C0030319	Panic Disorder	1	BeFree
umls:C0031099	Periodontitis	1	BeFree
umls:C0032051	Placental Insufficiency	1	BeFree
umls:C0032964	Pregnancy Complications, Hematologic	1	GAD
umls:C0033860	Psoriasis	1	BeFree
umls:C0036202	Sarcoidosis	1	LHGDN
umls:C0037274	Dermatologic disorders	1	GAD
umls:C0037763	Spasm	1	LHGDN
umls:C0038013	Ankylosing spondylitis	1	BeFree
umls:C0040021	Thromboangiitis Obliterans	1	BeFree
umls:C0040053	Thrombosis	1	GAD
umls:C0040336	Tobacco Use Disorder	1	GAD
umls:C0041671	Attention Deficit Disorder	1	BeFree
umls:C0041696	Unipolar Depression	1	BeFree
umls:C0041948	Uremia	1	BeFree,GAD
umls:C0042133	Uterine Fibroids	1	BeFree
umls:C0042755	Virilism	1	GAD
umls:C0042769	Virus Diseases	1	BeFree
umls:C0079731	B-Cell Lymphomas	1	BeFree
umls:C0079772	T-Cell Lymphoma	1	BeFree
umls:C0080178	Spina Bifida	1	BeFree,CTD_human,GAD
umls:C0085084	Motor Neuron Disease	1	BeFree
umls:C0085110	Severe Combined Immunodeficiency	1	BeFree
umls:C0085183	Neoplasms, Second Primary	1	GAD
umls:C0085207	Gestational Diabetes	1	BeFree
umls:C0085669	Acute leukemia	1	BeFree
umls:C0086132	Depressive Symptoms	1	BeFree
umls:C0149521	Pancreatitis, Chronic	1	BeFree,GAD,LHGDN
umls:C0149721	Left Ventricular Hypertrophy	1	LHGDN
umls:C0149925	Small cell carcinoma of lung	1	BeFree
umls:C0153633	Malignant neoplasm of brain	1	GAD
umls:C0155765	Disease of capillaries	1	BeFree
umls:C0158570	Vascular anomaly	1	BeFree
umls:C0162871	Aortic Aneurysm, Abdominal	1	GAD
umls:C0206081	Hyperandrogenism	1	GAD
umls:C0206172	Diabetic Foot	1	BeFree
umls:C0206663	Neuroectodermal Tumor, Primitive	1	CTD_human
umls:C0220810	Congenital defects	1	BeFree
umls:C0232197	Fibrillation	1	BeFree
umls:C0235032	Neurotoxicity Syndromes	1	CTD_human
umls:C0236969	Substance-Related Disorders	1	GAD
umls:C0242350	Erectile dysfunction	1	LHGDN
umls:C0242510	Drug usage	1	BeFree
umls:C0243038	Carcinoma, Lewis Lung	1	BeFree
umls:C0267375	Chronic colitis	1	BeFree
umls:C0270736	Essential Tremor	1	BeFree
umls:C0271650	Impaired glucose tolerance	1	BeFree
umls:C0272079	Hemoglobin C trait	1	BeFree
umls:C0275009	Pesticide poisoning	1	GAD
umls:C0311375	Arsenic Poisoning	1	GAD
umls:C0341439	Chronic liver disease	1	BeFree
umls:C0342257	Complications of Diabetes Mellitus	1	LHGDN
umls:C0376297	Cardiac Death	1	GAD
umls:C0376545	Hematologic Neoplasms	1	CTD_human
umls:C0376670	Pancreatitis, Alcoholic	1	GAD
umls:C0392514	Hereditary hemochromatosis	1	BeFree
umls:C0401149	Chronic constipation	1	BeFree
umls:C0409959	Osteoarthritis, Knee	1	LHGDN
umls:C0442874	Neuropathy	1	BeFree
umls:C0524910	Hepatitis C, Chronic	1	BeFree,GAD
umls:C0581375	Double coronary vessel disease	1	BeFree
umls:C0677886	Epithelial ovarian cancer	1	BeFree
umls:C0700613	Anxiety state	1	BeFree
umls:C0730345	Microalbuminuria	1	BeFree
umls:C0740394	Hyperuricemia	1	BeFree
umls:C0752308	Hypoxia-Ischemia, Brain	1	GAD
umls:C0853193	Bipolar I disorder	1	BeFree
umls:C0860207	Drug-Induced Liver Injury	1	CTD_human
umls:C0877854	Cerebral Arteriosclerosis	1	BeFree
umls:C0878521	Beta thalassemia trait	1	BeFree
umls:C0919267	ovarian neoplasm	1	GAD,LHGDN
umls:C1261287	Stenosis	1	GAD
umls:C1269683	Major Depressive Disorder	1	BeFree
umls:C1272641	Systemic arterial pressure	1	GAD
umls:C1279420	Anxiety neurosis (finding)	1	BeFree
umls:C1332977	Childhood Leukemia	1	BeFree
umls:C1458155	Mammary Neoplasms	1	LHGDN
umls:C1565489	Renal Insufficiency	1	GAD
umls:C1623038	Cirrhosis	1	BeFree
umls:C1704272	Benign Prostatic Hyperplasia	1	BeFree
umls:C1861172	Venous Thromboembolism	1	GAD
umls:C1862939	AMYOTROPHIC LATERAL SCLEROSIS 1	1	CTD_human
umls:C1868649	PANIC DISORDER 1	1	BeFree
umls:C1961121	Congenital vascular anomaly	1	BeFree
umls:C2239176	Liver carcinoma	1	BeFree
umls:C2718067	Alcoholic Steatohepatitis	1	BeFree
umls:C2919032	Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified	1	GAD
umls:C2919945	Cavernous Hemangioma of Brain	1	BeFree
umls:C2931456	Prostate cancer, familial	1	BeFree
umls:C1827841	Enzyme activity finding	0	CLINVAR
umls:C1840169	CORONARY ARTERY DISEASE, SUSCEPTIBILITY TO	0	CLINVAR
umls:C2674665	MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 5 (finding)	0	CLINVAR,CTD_human