TissGeneSummary for MOV10L1 |
Gene summary |
Basic gene information | Gene symbol | MOV10L1 |
Gene name | Mov10 RISC complex RNA helicase like 1 | |
Synonyms | CHAMP|DJ402G11.8 | |
Cytomap | UCSC genome browser: 22q13.33 | |
Type of gene | protein-coding | |
RefGenes | NM_001164104.1, NM_001164105.1,NM_001164106.1,NM_018995.2, | |
Description | MOV10-like protein 1Mov10-like 1Mov10l1, Moloney leukemia virus 10-like 1, homologcardiac helicase activated by MEF2C proteinmoloney leukemia virus 10-like protein 1putative helicase Mov10l1 | |
Modification date | 20141215 | |
dbXrefs | MIM : 605794 | |
HGNC : HGNC | ||
Ensembl : ENSG00000073146 | ||
HPRD : 16158 | ||
Vega : OTTHUMG00000044648 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MOV10L1 | |
BioGPS: 54456 | ||
Pathway | NCI Pathway Interaction Database: MOV10L1 | |
KEGG: MOV10L1 | ||
REACTOME: MOV10L1 | ||
Pathway Commons: MOV10L1 | ||
Context | iHOP: MOV10L1 | |
ligand binding site mutation search in PubMed: MOV10L1 | ||
UCL Cancer Institute: MOV10L1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MOV10L1 | ||
Description by TissGene annotations | Fused withOncogene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for MOV10L1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -1.349350349 | -2.642048023 | 1.292697674 | 8.22E-06 | 4.78E-05 |
PRAD | 0.265815214 | -1.432944401 | 1.698759615 | 1.40E-08 | 1.68E-07 |
KIRP | -3.372364593 | -1.811227093 | -1.5611375 | 1.71E-09 | 1.54E-08 |
ESCA | -1.04099073 | -3.163118002 | 2.122127273 | 0.00197 | 0.022583918 |
KICH | -0.305039093 | -1.673675093 | 1.368636 | 0.00359 | 0.006989717 |
Top |
TissGene-miRNA for MOV10L1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for MOV10L1 |
TissGeneSNV for MOV10L1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.T18S | COAD | 4 |
p.R762H | GBM | 1 |
p.P660S | ESCA | 1 |
p.V1073M | SKCM | 1 |
p.L142P | KIRC | 1 |
p.A1159T | SKCM | 1 |
p.A597V | UCEC | 1 |
p.A959T | PAAD | 1 |
p.N296S | BLCA | 1 |
p.H254Y | SKCM | 1 |
p.R424H | STAD | 1 |
p.T1067M | GBM | 1 |
p.D105N | SKCM | 1 |
p.T481I | SKCM | 1 |
p.E704K | SKCM | 1 |
p.R1120* | HNSC | 1 |
p.T15S | KIRP | 1 |
p.R984W | STAD | 1 |
p.R795Q | BLCA | 1 |
p.N267S | LGG | 1 |
p.V570F | OV | 1 |
p.G901R | GBM | 1 |
p.D793G | THCA | 1 |
p.V727I | HNSC | 1 |
p.V116A | SARC | 1 |
p.V798L | LUSC | 1 |
p.P406S | SKCM | 1 |
p.T687S | LUAD | 1 |
p.A250T | THYM | 1 |
p.G1159R | CESC | 1 |
p.G634C | READ | 1 |
p.L768I | UCEC | 1 |
p.P1037R | BLCA | 1 |
p.E834D | ESCA | 1 |
p.S233* | LUAD | 1 |
p.D56N | SKCM | 1 |
p.L264V | HNSC | 1 |
p.G385R | SKCM | 1 |
p.A1038T | SKCM | 1 |
p.P718R | BRCA | 1 |
p.A456S | LUSC | 1 |
p.G1147E | SKCM | 1 |
p.G298* | ACC | 1 |
p.Q302* | LUSC | 1 |
p.H278Y | STAD | 1 |
p.E458X | KIRP | 1 |
p.Q361E | SKCM | 1 |
p.C432F | SKCM | 1 |
p.R1027Q | COAD | 1 |
p.G285R | SKCM | 1 |
p.G298R | SKCM | 1 |
p.T1167A | LIHC | 1 |
p.A455S | LUAD | 1 |
p.M1086I | SKCM | 1 |
p.E200K | SKCM | 1 |
p.G419* | LUAD | 1 |
p.S363L | SKCM | 1 |
p.G1091A | HNSC | 1 |
p.G914A | UCEC | 1 |
p.V124M | UCEC | 1 |
p.E171K | BLCA | 1 |
p.G419R | HNSC | 1 |
p.S126F | SKCM | 1 |
p.A522V | UCEC | 1 |
p.V650F | THYM | 1 |
p.R1134X | READ | 1 |
p.Y947H | UCEC | 1 |
p.S579F | BLCA | 1 |
p.G759C | PRAD | 1 |
p.I664M | LUAD | 1 |
p.L1079I | UCEC | 1 |
p.A239V | UCEC | 1 |
p.E1163K | SKCM | 1 |
p.C380S | STAD | 1 |
p.F857I | UCEC | 1 |
p.G1029E | SKCM | 1 |
p.P571S | BRCA | 1 |
p.K283N | PAAD | 1 |
p.R812W | SKCM | 1 |
p.F1116L | STAD | 1 |
p.G419R | BRCA | 1 |
p.E1113G | STAD | 1 |
p.G154R | SKCM | 1 |
p.S336F | SKCM | 1 |
p.R286I | UCEC | 1 |
p.D388Y | UCEC | 1 |
p.T289A | UCEC | 1 |
p.S1107L | UCEC | 1 |
p.V1041I | GBM | 1 |
p.G563R | LUAD | 1 |
p.K283N | PRAD | 1 |
p.S2L | SKCM | 1 |
p.R440Q | BRCA | 1 |
p.G298E | SKCM | 1 |
p.G298X | ACC | 1 |
p.E1094D | UCEC | 1 |
p.E606Q | CESC | 1 |
p.D63Y | ESCA | 1 |
p.E1094K | CESC | 1 |
p.R248_splice | LUSC | 1 |
p.P660S | SKCM | 1 |
p.E976K | LUAD | 1 |
p.R762H | KICH | 1 |
p.N636T | UCEC | 1 |
p.D1098N | SKCM | 1 |
p.R424H | LUAD | 1 |
p.E1007Q | LGG | 1 |
p.K585I | LUSC | 1 |
p.Q395* | UCEC | 1 |
p.R488K | SKCM | 1 |
p.M554I | LUAD | 1 |
p.R1027Q | SKCM | 1 |
p.P422S | SKCM | 1 |
p.D50N | SKCM | 1 |
p.C187S | LUSC | 1 |
p.A840D | SKCM | 1 |
p.E575K | COAD | 1 |
p.R7C | HNSC | 1 |
p.Q469H | KIRC | 1 |
p.E579K | READ | 1 |
p.E171K | HNSC | 1 |
p.E180X | READ | 1 |
p.P1139S | SKCM | 1 |
p.G848E | SKCM | 1 |
p.Q497R | SARC | 1 |
p.E990K | SKCM | 1 |
p.R1154* | UCEC | 1 |
p.P496S | SKCM | 1 |
p.R1154* | SKCM | 1 |
p.K246N | CESC | 1 |
p.E549K | READ | 1 |
p.D1118N | SKCM | 1 |
p.K970N | UCEC | 1 |
p.H788R | UCEC | 1 |
p.D1175N | UCEC | 1 |
p.R440Q | SKCM | 1 |
p.P765S | LUSC | 1 |
p.S365R | KIRC | 1 |
p.L1123W | ESCA | 1 |
p.G89R | COAD | 1 |
p.R162W | COAD | 1 |
p.D1099Y | COAD | 1 |
p.E147D | LGG | 1 |
p.P375L | PAAD | 1 |
p.E599K | PAAD | 1 |
Top |
TissGeneCNV for MOV10L1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for MOV10L1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-C8-A27A-01A | MOV10L1-NAV2 | In-frame | Chr22:50555780 | Chr11:20005671 |
TCGAfusionPortal | PRADA | BRCA | TCGA-C8-A27A-01A | BCR-MOV10L1 | In-frame | Chr22:23524426 | Chr22:50530430 |
Top |
TissGeneNet for MOV10L1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for MOV10L1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for MOV10L1 |
TissGeneDrug for MOV10L1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for MOV10L1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0016048 | Fibromatosis | 1 | BeFree |
umls:C0021364 | Male infertility | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0205945 | Sarcoma, Spindle Cell | 1 | BeFree |
umls:C1261473 | Sarcoma | 1 | BeFree |