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| TissGeneSummary for PON3 |
 Gene summary |
| Basic gene information | Gene symbol | PON3 |
| Gene name | paraoxonase 3 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 7q21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000940.2, | |
| Description | arylesterase 3paraoxanase-3serum paraoxonase/lactonase 3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602720 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000105852 | ||
| HPRD : 04098 | ||
| Vega : OTTHUMG00000153917 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PON3 | |
| BioGPS: 5446 | ||
| Pathway | NCI Pathway Interaction Database: PON3 | |
| KEGG: PON3 | ||
| REACTOME: PON3 | ||
| Pathway Commons: PON3 | ||
| Context | iHOP: PON3 | |
| ligand binding site mutation search in PubMed: PON3 | ||
| UCL Cancer Institute: PON3 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of PON3 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0019439 | aromatic compound catabolic process | 15772423 | GO:0046395 | carboxylic acid catabolic process | 15772423 | GO:0019439 | aromatic compound catabolic process | 15772423 | GO:0046395 | carboxylic acid catabolic process | 15772423 |
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| TissGeneExp for PON3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -3.962679437 | 0.656108563 | -4.618788 | 2.02E-14 | 3.45E-13 |
| PRAD | -3.262234744 | -0.906065514 | -2.356169231 | 1.74E-09 | 2.53E-08 |
| KIRC | -2.328832714 | 0.325668675 | -2.654501389 | 3.98E-17 | 2.38E-16 |
| LIHC | 6.358814563 | 8.204360563 | -1.845546 | 2.91E-08 | 2.31E-07 |
| LUSC | 1.428458054 | 3.772301191 | -2.343843137 | 3.56E-11 | 1.40E-10 |
| KIRP | -3.600726812 | 0.457995063 | -4.058721875 | 9.19E-11 | 1.06E-09 |
| BRCA | 0.242386949 | 1.366298353 | -1.123911404 | 0.00027 | 0.000566648 |
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| TissGene-miRNA for PON3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PON3 |
| TissGeneSNV for PON3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G218E | SKCM | 2 |
| p.P287S | SKCM | 2 |
| p.D168E | THYM | 1 |
| p.I279V | KIRC | 1 |
| p.Q328* | HNSC | 1 |
| p.Q93* | UCEC | 1 |
| p.P72S | SKCM | 1 |
| p.S208N | COAD | 1 |
| p.G2R | SKCM | 1 |
| p.P72L | LUAD | 1 |
| p.P113L | SKCM | 1 |
| p.E81K | CESC | 1 |
| p.S228L | BRCA | 1 |
| p.D107N | SKCM | 1 |
| p.E211K | SKCM | 1 |
| p.L48R | STAD | 1 |
| p.K289E | UCEC | 1 |
| p.G68X | ESCA | 1 |
| p.V239L | BLCA | 1 |
| p.D56V | KIRC | 1 |
| p.G338E | UCEC | 1 |
| p.H160N | PRAD | 1 |
| p.N41Y | STAD | 1 |
| p.D107G | COAD | 1 |
| p.E146G | HNSC | 1 |
| p.L205F | LUAD | 1 |
| p.I57V | LIHC | 1 |
| p.D238Y | COAD | 1 |
| p.E92K | SKCM | 1 |
| p.H284Y | LUAD | 1 |
| p.E312K | LUAD | 1 |
| p.K3E | COAD | 1 |
| p.L190Q | BLCA | 1 |
| p.R200C | SKCM | 1 |
| p.E38K | UCEC | 1 |
| p.D123G | HNSC | 1 |
| p.K84N | STAD | 1 |
| p.L14M | STAD | 1 |
| p.E296A | LGG | 1 |
| p.L266F | ESCA | 1 |
| p.D121N | UCEC | 1 |
| p.P59H | STAD | 1 |
| p.D273V | ESCA | 1 |
| p.H43L | LIHC | 1 |
| p.N124K | LIHC | 1 |
| p.V335L | KIRC | 1 |
| p.S188F | SKCM | 1 |
| p.P274S | SKCM | 1 |
| p.S228* | BLCA | 1 |
| p.E33D | ESCA | 1 |
| p.R305H | HNSC | 1 |
| p.M195T | COAD | 1 |
| p.R200P | HNSC | 1 |
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| TissGeneCNV for PON3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PON3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for PON3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for PON3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PON3 |
| TissGeneDrug for PON3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PON3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004153 | Atherosclerosis | 9 | BeFree,GAD |
| umls:C0003850 | Arteriosclerosis | 7 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 5 | BeFree,GAD |
| umls:C0010068 | Coronary heart disease | 5 | BeFree,GAD,LHGDN |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 3 | GAD,ORPHANET |
| umls:C1956346 | Coronary Artery Disease | 3 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 2 | BeFree,GAD |
| umls:C0021368 | Inflammation | 2 | GAD |
| umls:C0024141 | Lupus Erythematosus, Systemic | 2 | BeFree,GAD |
| umls:C0151744 | Myocardial Ischemia | 2 | GAD |
| umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
| umls:C0007273 | Carotid Artery Diseases | 1 | GAD |
| umls:C0007570 | Celiac Disease | 1 | LHGDN |
| umls:C0010346 | Crohn Disease | 1 | BeFree |
| umls:C0017178 | Gastrointestinal Diseases | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | LHGDN |
| umls:C0021655 | Insulin Resistance | 1 | GAD |
| umls:C0023895 | Liver diseases | 1 | GAD |
| umls:C0024143 | Lupus Nephritis | 1 | GAD |
| umls:C0027051 | Myocardial Infarction | 1 | GAD |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C1704436 | Peripheral Arterial Diseases | 1 | BeFree |
| umls:C1862941 | Amyotrophic Lateral Sclerosis, Sporadic | 1 | BeFree |
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