TissGeneSummary for POU3F1 |
Gene summary |
Basic gene information | Gene symbol | POU3F1 |
Gene name | POU class 3 homeobox 1 | |
Synonyms | OCT6|OTF6|SCIP | |
Cytomap | UCSC genome browser: 1p34.1 | |
Type of gene | protein-coding | |
RefGenes | NM_002699.3, | |
Description | OTF-6POU domain transcription factor SCIPPOU domain, class 3, transcription factor 1octamer-binding protein 6octamer-binding transcription factor 6 | |
Modification date | 20141207 | |
dbXrefs | MIM : 602479 | |
HGNC : HGNC | ||
Ensembl : ENSG00000185668 | ||
HPRD : 03921 | ||
Vega : OTTHUMG00000000485 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_POU3F1 | |
BioGPS: 5453 | ||
Pathway | NCI Pathway Interaction Database: POU3F1 | |
KEGG: POU3F1 | ||
REACTOME: POU3F1 | ||
Pathway Commons: POU3F1 | ||
Context | iHOP: POU3F1 | |
ligand binding site mutation search in PubMed: POU3F1 | ||
UCL Cancer Institute: POU3F1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of POU3F1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for POU3F1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.901358784 | -1.809666784 | -1.091692 | 1.95E-05 | 5.83E-05 |
LUSC | 0.116386863 | -2.354387647 | 2.47077451 | 8.65E-11 | 3.31E-10 |
PRAD | -2.498975015 | -0.799413477 | -1.699561538 | 8.99E-12 | 3.02E-10 |
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TissGene-miRNA for POU3F1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for POU3F1 |
TissGeneSNV for POU3F1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E355K | BLCA | 2 |
p.R338C | COAD | 1 |
p.D374E | LUAD | 1 |
p.D248Y | BLCA | 1 |
p.K304N | UCEC | 1 |
p.T292N | STAD | 1 |
p.N314S | UCEC | 1 |
p.R266C | COAD | 1 |
p.K304N | ESCA | 1 |
p.R266C | STAD | 1 |
p.Q290H | HNSC | 1 |
p.R265W | STAD | 1 |
p.D254N | CESC | 1 |
p.A335T | SKCM | 1 |
p.P311S | PAAD | 1 |
p.R266H | STAD | 1 |
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TissGeneCNV for POU3F1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for POU3F1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for POU3F1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for POU3F1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for POU3F1 |
TissGeneDrug for POU3F1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for POU3F1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0003873 | Rheumatoid Arthritis | 2 | CTD_human,GAD |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0028945 | oligodendroglioma | 1 | BeFree |
umls:C0031117 | Peripheral Neuropathy | 1 | LHGDN |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0334590 | Anaplastic Oligodendroglioma | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0751396 | Well Differentiated Oligodendroglioma | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |