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| TissGeneSummary for CCHCR1 |
 Gene summary |
| Basic gene information | Gene symbol | CCHCR1 |
| Gene name | coiled-coil alpha-helical rod protein 1 | |
| Synonyms | C6orf18|HCR|SBP | |
| Cytomap | UCSC genome browser: 6p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001105563.1, NM_001105564.1,NM_019052.3, | |
| Description | HCR (a-helix coiled-coil rod homologue)StAR-binding proteinalpha-helical coiled-coil rod proteinpg8putative gene 8 protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605310 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000204536 | ||
| HPRD : 05607 | ||
| Vega : OTTHUMG00000031112 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CCHCR1 | |
| BioGPS: 54535 | ||
| Pathway | NCI Pathway Interaction Database: CCHCR1 | |
| KEGG: CCHCR1 | ||
| REACTOME: CCHCR1 | ||
| Pathway Commons: CCHCR1 | ||
| Context | iHOP: CCHCR1 | |
| ligand binding site mutation search in PubMed: CCHCR1 | ||
| UCL Cancer Institute: CCHCR1 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
| Reference showing the relevant tissue of CCHCR1 | Analysis of the coding sequence and expression of the coiled-coil α-helical rod protein 1 gene in normal and neoplastic epithelial cervical cells. Pacholska-Bogalska J, Myga-Nowak M, Ciepłuch K, Józefiak A, Kwaśniewska A, Goździcka-Józefiak A. Int J Mol Med. 2012 Apr;29(4):669-76. doi: 10.3892/ijmm.2012.877. Epub 2012 Jan 3. (pmid:22218424) go to article | |
| Description by TissGene annotations | TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CCHCR1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 1.336891286 | 0.317495286 | 1.019396 | 1.57E-11 | 2.37E-10 |
| KICH | -0.262186714 | 1.246797286 | -1.508984 | 4.18E-07 | 1.69E-06 |
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| TissGene-miRNA for CCHCR1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CCHCR1 |
| TissGeneSNV for CCHCR1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R156W | COAD | 2 |
| p.R162W | COAD | 2 |
| p.R613Q | HNSC | 1 |
| p.H444R | BRCA | 1 |
| p.E231K | BLCA | 1 |
| p.S33* | BLCA | 1 |
| p.S614F | ACC | 1 |
| p.S829C | COAD | 1 |
| p.Y686* | LUSC | 1 |
| p.L497M | LUAD | 1 |
| p.G169E | SKCM | 1 |
| p.E306Q | BLCA | 1 |
| p.L163P | KICH | 1 |
| p.R155Q | COAD | 1 |
| p.R201L | LIHC | 1 |
| p.R702W | PRAD | 1 |
| p.E290X | CHOL | 1 |
| p.T365N | PAAD | 1 |
| p.R193Q | SKCM | 1 |
| p.H275D | HNSC | 1 |
| p.V805L | LIHC | 1 |
| p.A191V | SKCM | 1 |
| p.R229Q | SKCM | 1 |
| p.L232Q | COAD | 1 |
| p.R710S | BLCA | 1 |
| p.A227V | SKCM | 1 |
| p.M60I | STAD | 1 |
| p.V853F | LUSC | 1 |
| p.A720V | ESCA | 1 |
| p.G343V | PRAD | 1 |
| p.R487C | UCEC | 1 |
| p.R731L | KIRC | 1 |
| p.S650F | ACC | 1 |
| p.E515K | BLCA | 1 |
| p.M1I | LGG | 1 |
| p.L126P | GBM | 1 |
| p.P36S | SKCM | 1 |
| p.E37K | LUAD | 1 |
| p.A395T | UCEC | 1 |
| p.Y785C | LUSC | 1 |
| p.P125S | SKCM | 1 |
| p.R470Q | COAD | 1 |
| p.R702Q | HNSC | 1 |
| p.M149I | STAD | 1 |
| p.S374F | SKCM | 1 |
| p.L199P | KICH | 1 |
| p.G453V | PRAD | 1 |
| p.P32L | SKCM | 1 |
| p.S281C | LUAD | 1 |
| p.D327H | LUAD | 1 |
| p.S814L | BLCA | 1 |
| p.V471A | STAD | 1 |
| p.Q545H | LIHC | 1 |
| p.A600P | HNSC | 1 |
| p.W78X | COAD | 1 |
| p.M869I | BLCA | 1 |
| p.D29N | CESC | 1 |
| p.A435V | STAD | 1 |
| p.S706* | BLCA | 1 |
| p.R201Q | KIRC | 1 |
| p.R552* | SKCM | 1 |
| p.R621W | BLCA | 1 |
| p.M780I | BLCA | 1 |
| p.R163Q | PRAD | 1 |
| p.R470W | COAD | 1 |
| p.E490D | HNSC | 1 |
| p.M23V | LIHC | 1 |
| p.P58S | STAD | 1 |
| p.S348F | CESC | 1 |
| p.S725L | BLCA | 1 |
| p.V448L | BLCA | 1 |
| p.S491I | LUAD | 1 |
| p.E41X | COAD | 1 |
| p.E482* | LUAD | 1 |
| p.T276N | PAAD | 1 |
| p.R676L | LUAD | 1 |
| p.E579D | HNSC | 1 |
| p.L705F | LUAD | 1 |
| p.L794F | LUAD | 1 |
| p.E356* | BLCA | 1 |
| p.R558C | UCEC | 1 |
| p.H186D | HNSC | 1 |
| p.E233K | BLCA | 1 |
| p.S410F | SKCM | 1 |
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| TissGeneCNV for CCHCR1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CCHCR1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF901504 | CCHCR1-CDA | chr6:2413749 | chr1:20938233 |
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| TissGeneNet for CCHCR1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (tumor) | CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (normal) |
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| COAD (tumor) | COAD (normal) |
| CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (tumor) | CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (tumor) | CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (normal) |
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| KICH (tumor) | KICH (normal) |
| CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (tumor) | CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (tumor) | CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (tumor) | CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (tumor) | CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (tumor) | CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (tumor) | CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (tumor) | CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (normal) |
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| STAD (tumor) | STAD (normal) |
| CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (tumor) | CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (normal) |
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| THCA (tumor) | THCA (normal) |
| CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (tumor) | CCHCR1, PRKCG, IKBKG, POLR2C, STAR, POLD2, TRAF4 (normal) |
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| TissGeneProg for CCHCR1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CCHCR1 |
| TissGeneDrug for CCHCR1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CCHCR1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0033860 | Psoriasis | 20 | BeFree,GAD,LHGDN |
| umls:C0020538 | Hypertensive disease | 8 | BeFree |
| umls:C0028754 | Obesity | 4 | BeFree |
| umls:C0003872 | Arthritis, Psoriatic | 3 | BeFree,GAD |
| umls:C0011847 | Diabetes | 3 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 3 | BeFree |
| umls:C0263361 | Psoriasis vulgaris | 3 | BeFree |
| umls:C0004096 | Asthma | 2 | BeFree |
| umls:C0008533 | Hemophilia B | 2 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree |
| umls:C0004943 | Behcet Syndrome | 1 | GAD |
| umls:C0007113 | Rectal Carcinoma | 1 | BeFree |
| umls:C0007114 | Malignant neoplasm of skin | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 1 | GAD,GWASCAT |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0014457 | Eosinophilia | 1 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 1 | GAD |
| umls:C0025303 | Meningococcal Infections | 1 | GAD |
| umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human,GAD |
| umls:C0037274 | Dermatologic disorders | 1 | BeFree |
| umls:C0037286 | Skin Neoplasms | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0085096 | Peripheral Vascular Diseases | 1 | BeFree |
| umls:C0085762 | Alcohol abuse | 1 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0155877 | Allergic asthma | 1 | BeFree |
| umls:C0157738 | Chronic skin ulcer | 1 | BeFree |
| umls:C0220726 | Diastrophic dysplasia | 1 | BeFree |
| umls:C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| umls:C0243026 | Sepsis | 1 | GAD |
| umls:C0262975 | Chronic dermatitis | 1 | BeFree |
| umls:C0268450 | Gitelman Syndrome | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | GWASCAT |
| umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
| umls:C0595921 | Intraocular pressure disorder | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0751688 | Malignant Squamous Cell Neoplasm | 1 | BeFree |
| umls:C1306759 | Eosinophilic disorder | 1 | BeFree |
| umls:C1636667 | Disorder characterized by eosinophilia | 1 | BeFree |
| umls:C3811653 | Experimental Organism Basal Cell Carcinoma | 1 | BeFree |
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