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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for DDIT4
check button Gene summary
Basic gene informationGene symbolDDIT4
Gene nameDNA-damage-inducible transcript 4
SynonymsDig2|REDD-1|REDD1
CytomapUCSC genome browser: 10q22.1
Type of geneprotein-coding
RefGenesNM_019058.2,
DescriptionDNA damage-inducible transcript 4 proteinHIF-1 responsive protein RTP801protein regulated in development and DNA damage response 1
Modification date20141207
dbXrefs MIM : 607729
HGNC : HGNC
Ensembl : ENSG00000168209
HPRD : 09662
Vega : OTTHUMG00000183961
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DDIT4
BioGPS: 54541
PathwayNCI Pathway Interaction Database: DDIT4
KEGG: DDIT4
REACTOME: DDIT4
Pathway Commons: DDIT4
ContextiHOP: DDIT4
ligand binding site mutation search in PubMed: DDIT4
UCL Cancer Institute: DDIT4
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)CervixOvary
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)CESCOV
Reference showing the relevant tissue of DDIT4
Description by TissGene annotationsHave significant anti-correlated miRNA
TissgsLTS
Fused withOncogene
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0001666response to hypoxia20166753
GO:0001666response to hypoxia20166753


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TissGeneExp for DDIT4

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
PRAD0.9769129172.200941763-1.2240288461.62E-081.91E-07
COAD1.7912186860.4926956091.2985230772.31E-081.87E-07
HNSC3.0529123351.8138402421.2390720932.24E-061.54E-05
KIRC3.3903170831.2951740282.0951430561.13E-251.42E-24
LUAD2.2991482611.1356086061.1635396553.29E-071.19E-06
LUSC2.5086143871.443247721.0653666678.69E-050.000181371


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TissGene-miRNA for DDIT4

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
UCShsa-miR-199b-3pMIMAT00045630.022-0.3156
UCShsa-miR-199a-3pMIMAT00002320.023-0.3156
UCShsa-miR-92b-3pMIMAT00032180.014-0.3356


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TissGeneMut for DDIT4
TissGeneSNV for DDIT4

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G75RLUSC1
p.D27HCESC1
p.H158YLUAD1
p.H91RUCEC1
p.S224LBLCA1
p.S111FPAAD1
p.E90GLUAD1
p.E152KSTAD1
p.P66SPRAD1
p.A37VLUSC1
p.S32LBLCA1
p.S77PSKCM1
p.S52WLIHC1
p.P2SLUAD1
p.Y136CLUAD1
p.R143WUCEC1
p.L179QPRAD1
p.H91NKICH1


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TissGeneCNV for DDIT4

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for DDIT4

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABE772578AZGP1P1-DDIT4chr7:99580876chr10:74034947
Chimerdb3.0ChiTaRsNADW438966H19-DDIT4chr11:2018969chr10:74035655
Chimerdb3.0ChiTaRsNACB162888DDIT4-DDIT4chr10:74034737chr10:74034744
Chimerdb3.0ChiTaRsNABQ773488NUDCD3-DDIT4chr7:44507966chr10:74034858
Chimerdb3.0ChiTaRsNABE774996DDIT4-CSNK1Dchr10:74035603chr17:80209314
Chimerdb3.0ChiTaRsNABF930964NDRG2-DDIT4chr14:21487891chr10:74035024


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TissGeneNet for DDIT4

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (tumor)DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (normal)
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COAD (tumor)COAD (normal)
DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (tumor)DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (normal)
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HNSC (tumor)HNSC (normal)
DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (tumor)DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (normal)
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KICH (tumor)KICH (normal)
DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (tumor)DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (normal)
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KIRC (tumor)KIRC (normal)
DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (tumor)DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (normal)
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KIRP (tumor)KIRP (normal)
DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (tumor)DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (normal)
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LIHC (tumor)LIHC (normal)
DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (tumor)DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (normal)
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LUAD (tumor)LUAD (normal)
DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (tumor)DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (normal)
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LUSC (tumor)LUSC (normal)
DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (tumor)DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (normal)
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PRAD (tumor)PRAD (normal)
DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (tumor)DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (normal)
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STAD (tumor)STAD (normal)
DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (tumor)DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (normal)
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THCA (tumor)THCA (normal)
DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (tumor)DDIT4, UBC, YWHAZ, PLCG1, HSPA4, BTRC, RIF1, CUL4A, DDB1, PDPK1 (normal)
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TissGeneProg for DDIT4

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for DDIT4
TissGeneDrug for DDIT4

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for DDIT4

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0041341Tuberous Sclerosis6BeFree,LHGDN
umls:C0006142Malignant neoplasm of breast3BeFree
umls:C0678222Breast Carcinoma3BeFree
umls:C0002395Alzheimer's Disease2BeFree,LHGDN
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0242383Age related macular degeneration2BeFree
umls:C0596263Carcinogenesis2BeFree
umls:C1140680Malignant neoplasm of ovary2BeFree
umls:C0003130Anoxia1LHGDN
umls:C0003469Anxiety Disorders1BeFree
umls:C0003873Rheumatoid Arthritis1CTD_human
umls:C0007137Squamous cell carcinoma1LHGDN
umls:C0023418leukemia1BeFree,CTD_human
umls:C0023467Leukemia, Myelocytic, Acute1BeFree
umls:C0023470Myeloid Leukemia1BeFree
umls:C0026636Mouth Diseases1CTD_human
umls:C0026764Multiple Myeloma1BeFree
umls:C0027746Nerve Degeneration1CTD_human
umls:C0030567Parkinson Disease1CTD_human
umls:C0033578Prostatic Neoplasms1LHGDN
umls:C0034067Pulmonary Emphysema1BeFree
umls:C0041696Unipolar Depression1BeFree
umls:C0151514Atrophic condition of skin1BeFree
umls:C0206701Cystadenocarcinoma, Serous1BeFree
umls:C0242350Erectile dysfunction1BeFree
umls:C0346429Multiple malignancy1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C1168401Squamous cell carcinoma of the head and neck1BeFree
umls:C1269683Major Depressive Disorder1BeFree
umls:C1559271Non-Malignant Ascites Adverse Event1BeFree