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| TissGeneSummary for UGT1A7 |
 Gene summary |
| Basic gene information | Gene symbol | UGT1A7 |
| Gene name | ||
| Synonyms | ||
| Cytomap | UCSC genome browser: | |
| Type of gene | ||
| RefGenes | ||
| Description | ||
| Modification date | ||
| dbXrefs | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_UGT1A7 | |
| BioGPS: 54576 | ||
| Pathway | NCI Pathway Interaction Database: UGT1A7 | |
| KEGG: UGT1A7 | ||
| REACTOME: UGT1A7 | ||
| Pathway Commons: UGT1A7 | ||
| Context | iHOP: UGT1A7 | |
| ligand binding site mutation search in PubMed: UGT1A7 | ||
| UCL Cancer Institute: UGT1A7 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCATGCT | |
| Reference showing the relevant tissue of UGT1A7 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for UGT1A7 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 1.842827314 | -2.299002098 | 4.141829412 | 4.39E-08 | 1.29E-07 |
| COAD | -2.604509262 | -0.891578493 | -1.712930769 | 0.000736 | 0.002185062 |
| HNSC | 1.925620702 | 5.332034655 | -3.406413953 | 0.000247 | 0.000987123 |
| KICH | -2.724474647 | -1.584566647 | -1.139908 | 8.46E-05 | 0.000224649 |
| Top |
| TissGene-miRNA for UGT1A7 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for UGT1A7 |
| TissGeneSNV for UGT1A7 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S188F | SKCM | 3 |
| p.W208R | COAD | 1 |
| p.L133S | SKCM | 1 |
| p.P149L | BLCA | 1 |
| p.R254Q | SKCM | 1 |
| p.C220F | LUAD | 1 |
| p.G171E | LGG | 1 |
| p.L235I | UCEC | 1 |
| p.R97L | LUAD | 1 |
| p.R103Q | UCEC | 1 |
| p.E233G | UCEC | 1 |
| p.N226K | THYM | 1 |
| p.P164S | SKCM | 1 |
| p.A158V | SKCM | 1 |
| p.P149L | SKCM | 1 |
| p.T240M | PRAD | 1 |
| p.E135K | SKCM | 1 |
| p.D95N | SKCM | 1 |
| p.T99M | HNSC | 1 |
| p.R254Q | COAD | 1 |
| p.Y189C | STAD | 1 |
| p.Y136* | UCEC | 1 |
| p.R3H | UCS | 1 |
| p.R88W | UCEC | 1 |
| p.G26W | LUAD | 1 |
| p.L193I | LUAD | 1 |
| p.R131Q | COAD | 1 |
| p.P262L | SKCM | 1 |
| p.A144G | LUAD | 1 |
| p.N129K | COAD | 1 |
| p.P11L | SKCM | 1 |
| p.V283A | LGG | 1 |
| p.K138Q | SKCM | 1 |
| p.F39L | LGG | 1 |
| p.L187V | KIRC | 1 |
| p.P238S | LUAD | 1 |
| p.G8C | LUAD | 1 |
| p.R103Q | STAD | 1 |
| p.G180S | KIRC | 1 |
| p.S112L | SKCM | 1 |
| p.L177V | HNSC | 1 |
| p.N226H | UCEC | 1 |
| p.L119V | UCEC | 1 |
| p.T240M | ESCA | 1 |
| p.A152T | KIRC | 1 |
| Top |
| TissGeneCNV for UGT1A7 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| Top |
| TissGeneFusions for UGT1A7 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for UGT1A7 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for UGT1A7 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for UGT1A7 |
| TissGeneDrug for UGT1A7 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for UGT1A7 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1527249 | Colorectal Cancer | 11 | BeFree,GAD |
| umls:C2239176 | Liver carcinoma | 7 | BeFree,GAD,LHGDN |
| umls:C0009402 | Colorectal Carcinoma | 6 | BeFree |
| umls:C0010324 | Crigler Najjar syndrome, type 1 | 6 | BeFree |
| umls:C0020433 | Hyperbilirubinemia | 5 | BeFree,GAD |
| umls:C0596263 | Carcinogenesis | 5 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 4 | GAD,LHGDN |
| umls:C0017551 | Gilbert Disease (disorder) | 4 | GAD |
| umls:C0019163 | Hepatitis B | 4 | BeFree,GAD,LHGDN |
| umls:C0149521 | Pancreatitis, Chronic | 4 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 4 | BeFree,GAD |
| umls:C0019196 | Hepatitis C | 3 | BeFree,GAD |
| umls:C0023903 | Liver neoplasms | 3 | GAD |
| umls:C0235974 | Pancreatic carcinoma | 3 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree,GAD |
| umls:C0278996 | Cancer of Head and Neck | 3 | BeFree,GAD |
| umls:C0345904 | Malignant neoplasm of liver | 3 | BeFree,GAD |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree,GAD |
| umls:C0011991 | Diarrhea | 2 | BeFree,GAD |
| umls:C0023890 | Liver Cirrhosis | 2 | BeFree,GAD,LHGDN |
| umls:C0027947 | Neutropenia | 2 | BeFree,GAD |
| umls:C0281361 | Adenocarcinoma of pancreas | 2 | BeFree |
| umls:C0376670 | Pancreatitis, Alcoholic | 2 | GAD |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C0685938 | Malignant neoplasm of gastrointestinal tract | 2 | BeFree |
| umls:C0000737 | Abdominal Pain | 1 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007107 | Malignant neoplasm of larynx | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
| umls:C0010346 | Crohn Disease | 1 | BeFree,GAD |
| umls:C0011053 | Deafness | 1 | GAD |
| umls:C0011226 | Hepatitis D Infection | 1 | BeFree |
| umls:C0012860 | DNA Damage | 1 | GAD |
| umls:C0013182 | Drug Allergy | 1 | GAD |
| umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
| umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
| umls:C0021400 | Influenza | 1 | BeFree |
| umls:C0023530 | Leukopenia | 1 | BeFree |
| umls:C0024143 | Lupus Nephritis | 1 | GAD |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree,GAD |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree,LHGDN |
| umls:C0030286 | Pancreatic Diseases | 1 | BeFree |
| umls:C0030305 | Pancreatitis | 1 | BeFree |
| umls:C0042384 | Vasculitis | 1 | GAD |
| umls:C0042769 | Virus Diseases | 1 | BeFree |
| umls:C0341439 | Chronic liver disease | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0394006 | Dysequilibrium syndrome | 1 | BeFree |
| umls:C0524909 | Hepatitis B, Chronic | 1 | BeFree,GAD |
| umls:C0595989 | Carcinoma of larynx | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0746883 | Febrile Neutropenia | 1 | BeFree |
| umls:C0751075 | Cancer of Digestive System | 1 | BeFree |
| umls:C0810032 | Pancreatic disorders (not diabetes) | 1 | BeFree |
| umls:C0948380 | Colorectal cancer metastatic | 1 | BeFree |
| umls:C1384666 | hearing impairment | 1 | GAD |
| umls:C1512409 | Hepatocarcinogenesis | 1 | BeFree |
| umls:C1623038 | Cirrhosis | 1 | BeFree |
| umls:C3887873 | Hearing Loss | 1 | GAD |
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