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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for UGT1A3
check button Gene summary
Basic gene informationGene symbolUGT1A3
Gene nameUDP glucuronosyltransferase 1 family, polypeptide A3
SynonymsUDPGT|UDPGT 1-3|UGT-1C|UGT1-03|UGT1.3|UGT1C
CytomapUCSC genome browser: 2q37
Type of geneprotein-coding
RefGenesNM_019093.2,
DescriptionUDP glycosyltransferase 1 family, polypeptide A3UDP-glucuronosyltransferase 1-3UDP-glucuronosyltransferase 1-CUDP-glucuronosyltransferase 1A3UGT1*3
Modification date20141211
dbXrefs MIM : 606428
HGNC : HGNC
Ensembl : ENSG00000243135
HPRD : 07566
Vega : OTTHUMG00000059118
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_UGT1A3
BioGPS: 54659
PathwayNCI Pathway Interaction Database: UGT1A3
KEGG: UGT1A3
REACTOME: UGT1A3
Pathway Commons: UGT1A3
ContextiHOP: UGT1A3
ligand binding site mutation search in PubMed: UGT1A3
UCL Cancer Institute: UGT1A3
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,TiGER
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)LiverTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHCTGCT
Reference showing the relevant tissue of UGT1A3
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0052695cellular glucuronidation17179145
GO:0052696flavonoid glucuronidation20056724
GO:0052697xenobiotic glucuronidation20056724
GO:0052695cellular glucuronidation17179145
GO:0052696flavonoid glucuronidation20056724
GO:0052697xenobiotic glucuronidation20056724


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TissGeneExp for UGT1A3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
PRAD2.038720932-0.2850944532.3238153851.73E-058.89E-05
KIRC1.69017606-1.3801711623.0703472222.02E-211.75E-20
LUSC-0.389821489-2.2994940381.9096725494.20E-101.49E-09
LIHC6.0228143937.720974393-1.698160.0003880.001159822


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TissGene-miRNA for UGT1A3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for UGT1A3
TissGeneSNV for UGT1A3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.S83LSKCM4
p.R91CSKCM3
p.R284GSKCM2
p.R284GTHCA1
p.S236FSKCM1
p.H68YTHYM1
p.I276TTHCA1
p.N73KSTAD1
p.T62ISKCM1
p.Q6HLUAD1
p.E72DCOAD1
p.R210MPRAD1
p.P230TBLCA1
p.T103ASTAD1
p.E46QLUAD1
p.P195SSKCM1
p.P153LSKCM1
p.A232TUCEC1
p.Q240HLUAD1
p.Q209KACC1
p.G184DSKCM1
p.M214LLUAD1
p.R258QSKCM1
p.D152NSKCM1
p.S253FBLCA1
p.A2TBLCA1
p.I279VBLCA1
p.E135DLUAD1
p.R91HUCEC1
p.P8LSKCM1
p.Q186RKIRP1
p.S145FSKCM1
p.D260GLIHC1
p.P63QSKCM1
p.M273TKIRP1
p.H140NBRCA1
p.R284GLGG1


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TissGeneCNV for UGT1A3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for UGT1A3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for UGT1A3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)


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TissGeneProg for UGT1A3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for UGT1A3
TissGeneDrug for UGT1A3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for UGT1A3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0010324Crigler Najjar syndrome, type 16BeFree
umls:C0020433Hyperbilirubinemia5BeFree,GAD
umls:C0008370Cholestasis2BeFree
umls:C0004096Asthma1BeFree
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0011053Deafness1GAD
umls:C0011226Hepatitis D Infection1BeFree
umls:C0013291Duodenal Neoplasms1GAD
umls:C0017551Gilbert Disease (disorder)1GAD
umls:C0018772Hearing Loss, Partial1GAD
umls:C0021400Influenza1BeFree
umls:C0032580Adenomatous Polyposis Coli1BeFree,GAD
umls:C0036341Schizophrenia1CTD_human
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0334294Multiple adenomatous polyps1BeFree
umls:C0345904Malignant neoplasm of liver1GAD
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0394006Dysequilibrium syndrome1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0860207Drug-Induced Liver Injury1GAD
umls:C1268717Mammographic breast density1GAD
umls:C1337013Differentiated Thyroid Gland Carcinoma1BeFree
umls:C1384666hearing impairment1GAD
umls:C3887873Hearing Loss1GAD