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| TissGeneSummary for UGT1A3 |
 Gene summary |
| Basic gene information | Gene symbol | UGT1A3 |
| Gene name | UDP glucuronosyltransferase 1 family, polypeptide A3 | |
| Synonyms | UDPGT|UDPGT 1-3|UGT-1C|UGT1-03|UGT1.3|UGT1C | |
| Cytomap | UCSC genome browser: 2q37 | |
| Type of gene | protein-coding | |
| RefGenes | NM_019093.2, | |
| Description | UDP glycosyltransferase 1 family, polypeptide A3UDP-glucuronosyltransferase 1-3UDP-glucuronosyltransferase 1-CUDP-glucuronosyltransferase 1A3UGT1*3 | |
| Modification date | 20141211 | |
| dbXrefs | MIM : 606428 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000243135 | ||
| HPRD : 07566 | ||
| Vega : OTTHUMG00000059118 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_UGT1A3 | |
| BioGPS: 54659 | ||
| Pathway | NCI Pathway Interaction Database: UGT1A3 | |
| KEGG: UGT1A3 | ||
| REACTOME: UGT1A3 | ||
| Pathway Commons: UGT1A3 | ||
| Context | iHOP: UGT1A3 | |
| ligand binding site mutation search in PubMed: UGT1A3 | ||
| UCL Cancer Institute: UGT1A3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCTGCT | |
| Reference showing the relevant tissue of UGT1A3 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0052695 | cellular glucuronidation | 17179145 | GO:0052696 | flavonoid glucuronidation | 20056724 | GO:0052697 | xenobiotic glucuronidation | 20056724 | GO:0052695 | cellular glucuronidation | 17179145 | GO:0052696 | flavonoid glucuronidation | 20056724 | GO:0052697 | xenobiotic glucuronidation | 20056724 |
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| TissGeneExp for UGT1A3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | 2.038720932 | -0.285094453 | 2.323815385 | 1.73E-05 | 8.89E-05 |
| KIRC | 1.69017606 | -1.380171162 | 3.070347222 | 2.02E-21 | 1.75E-20 |
| LUSC | -0.389821489 | -2.299494038 | 1.909672549 | 4.20E-10 | 1.49E-09 |
| LIHC | 6.022814393 | 7.720974393 | -1.69816 | 0.000388 | 0.001159822 |
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| TissGene-miRNA for UGT1A3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for UGT1A3 |
| TissGeneSNV for UGT1A3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S83L | SKCM | 4 |
| p.R91C | SKCM | 3 |
| p.R284G | SKCM | 2 |
| p.R284G | THCA | 1 |
| p.S236F | SKCM | 1 |
| p.H68Y | THYM | 1 |
| p.I276T | THCA | 1 |
| p.N73K | STAD | 1 |
| p.T62I | SKCM | 1 |
| p.Q6H | LUAD | 1 |
| p.E72D | COAD | 1 |
| p.R210M | PRAD | 1 |
| p.P230T | BLCA | 1 |
| p.T103A | STAD | 1 |
| p.E46Q | LUAD | 1 |
| p.P195S | SKCM | 1 |
| p.P153L | SKCM | 1 |
| p.A232T | UCEC | 1 |
| p.Q240H | LUAD | 1 |
| p.Q209K | ACC | 1 |
| p.G184D | SKCM | 1 |
| p.M214L | LUAD | 1 |
| p.R258Q | SKCM | 1 |
| p.D152N | SKCM | 1 |
| p.S253F | BLCA | 1 |
| p.A2T | BLCA | 1 |
| p.I279V | BLCA | 1 |
| p.E135D | LUAD | 1 |
| p.R91H | UCEC | 1 |
| p.P8L | SKCM | 1 |
| p.Q186R | KIRP | 1 |
| p.S145F | SKCM | 1 |
| p.D260G | LIHC | 1 |
| p.P63Q | SKCM | 1 |
| p.M273T | KIRP | 1 |
| p.H140N | BRCA | 1 |
| p.R284G | LGG | 1 |
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| TissGeneCNV for UGT1A3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for UGT1A3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for UGT1A3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for UGT1A3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for UGT1A3 |
| TissGeneDrug for UGT1A3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for UGT1A3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0010324 | Crigler Najjar syndrome, type 1 | 6 | BeFree |
| umls:C0020433 | Hyperbilirubinemia | 5 | BeFree,GAD |
| umls:C0008370 | Cholestasis | 2 | BeFree |
| umls:C0004096 | Asthma | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0011053 | Deafness | 1 | GAD |
| umls:C0011226 | Hepatitis D Infection | 1 | BeFree |
| umls:C0013291 | Duodenal Neoplasms | 1 | GAD |
| umls:C0017551 | Gilbert Disease (disorder) | 1 | GAD |
| umls:C0018772 | Hearing Loss, Partial | 1 | GAD |
| umls:C0021400 | Influenza | 1 | BeFree |
| umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree,GAD |
| umls:C0036341 | Schizophrenia | 1 | CTD_human |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0334294 | Multiple adenomatous polyps | 1 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 1 | GAD |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0394006 | Dysequilibrium syndrome | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | GAD |
| umls:C1268717 | Mammographic breast density | 1 | GAD |
| umls:C1337013 | Differentiated Thyroid Gland Carcinoma | 1 | BeFree |
| umls:C1384666 | hearing impairment | 1 | GAD |
| umls:C3887873 | Hearing Loss | 1 | GAD |
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