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| TissGeneSummary for FEV |
 Gene summary |
| Basic gene information | Gene symbol | FEV |
| Gene name | FEV (ETS oncogene family) | |
| Synonyms | HSRNAFEV|PET-1 | |
| Cytomap | UCSC genome browser: 2q36 | |
| Type of gene | protein-coding | |
| RefGenes | NM_017521.2, | |
| Description | PC12 ETS domain-containing transcription factor 1fifth Ewing variant proteinprotein FEV | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607150 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000163497 | ||
| HPRD : 06193 | ||
| Vega : OTTHUMG00000133080 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FEV | |
| BioGPS: 54738 | ||
| Pathway | NCI Pathway Interaction Database: FEV | |
| KEGG: FEV | ||
| REACTOME: FEV | ||
| Pathway Commons: FEV | ||
| Context | iHOP: FEV | |
| ligand binding site mutation search in PubMed: FEV | ||
| UCL Cancer Institute: FEV | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasProstate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADPRAD | |
| Reference showing the relevant tissue of FEV | ||
| Description by TissGene annotations | Protective TissGene in RFS Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for FEV |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | -0.154747878 | 4.072855968 | -4.227603846 | 2.04E-19 | 7.45E-17 |
| PRAD | 6.866227122 | 4.338971353 | 2.527255769 | 3.33E-10 | 6.22E-09 |
| STAD | 1.059120632 | 2.970245632 | -1.911125 | 0.0109 | 0.036918825 |
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| TissGene-miRNA for FEV |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FEV |
| TissGeneSNV for FEV |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Y107H | UCEC | 1 |
| p.R125H | COAD | 1 |
| p.A140T | STAD | 1 |
| p.A132E | COAD | 1 |
| p.Q46E | LGG | 1 |
| p.N97I | LUAD | 1 |
| p.F128S | STAD | 1 |
| p.Q46H | UCEC | 1 |
| p.Y15C | LIHC | 1 |
| p.G71C | STAD | 1 |
| p.A123T | UCEC | 1 |
| p.A123V | LUAD | 1 |
| p.Y124C | UCEC | 1 |
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| TissGeneCNV for FEV |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FEV |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for FEV |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for FEV |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FEV |
| TissGeneDrug for FEV |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FEV |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004096 | Asthma | 78 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 29 | BeFree |
| umls:C0001883 | Airway Obstruction | 6 | BeFree |
| umls:C0024115 | Lung diseases | 6 | BeFree |
| umls:C0034067 | Pulmonary Emphysema | 6 | BeFree |
| umls:C0340068 | Aspirin-sensitive asthma with nasal polyps | 5 | BeFree |
| umls:C0008677 | Bronchitis, Chronic | 4 | BeFree |
| umls:C0085129 | Bronchial Hyperreactivity | 4 | BeFree |
| umls:C0553580 | Ewings sarcoma | 4 | BeFree |
| umls:C0014457 | Eosinophilia | 3 | BeFree |
| umls:C0221757 | alpha 1-Antitrypsin Deficiency | 3 | BeFree |
| umls:C1306759 | Eosinophilic disorder | 3 | BeFree |
| umls:C1636667 | Disorder characterized by eosinophilia | 3 | BeFree |
| umls:C0003469 | Anxiety Disorders | 2 | BeFree |
| umls:C0038644 | Sudden infant death syndrome | 2 | BeFree,LHGDN |
| umls:C0206062 | Lung Diseases, Interstitial | 2 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
| umls:C0476227 | pricking of skin | 2 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C0011570 | Mental Depression | 1 | BeFree |
| umls:C0011581 | Depressive disorder | 1 | BeFree |
| umls:C0013404 | Dyspnea | 1 | BeFree |
| umls:C0026846 | Muscular Atrophy | 1 | BeFree |
| umls:C0032326 | Pneumothorax | 1 | BeFree |
| umls:C0034068 | Pulmonary Eosinophilia | 1 | BeFree |
| umls:C0035204 | Respiration Disorders | 1 | BeFree |
| umls:C0035412 | Rhabdomyosarcoma | 1 | BeFree |
| umls:C0151744 | Myocardial Ischemia | 1 | CTD_human |
| umls:C0155877 | Allergic asthma | 1 | BeFree |
| umls:C0264408 | Childhood asthma | 1 | BeFree |
| umls:C0271650 | Impaired glucose tolerance | 1 | BeFree |
| umls:C0340076 | Asthmatic pulmonary eosinophilia | 1 | BeFree |
| umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |
| umls:C0425449 | Gasping for breath | 1 | BeFree |
| umls:C0426576 | Gastrointestinal symptom | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0525045 | Mood Disorders | 1 | BeFree |
| umls:C0585186 | Cutaneous hypersensitivity | 1 | BeFree |
| umls:C0600260 | Lung Diseases, Obstructive | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0699949 | airway disease | 1 | BeFree |
| umls:C0729233 | Dissecting aneurysm of the thoracic aorta | 1 | BeFree |
| umls:C0742343 | Acute Chest Syndrome | 1 | BeFree |
| umls:C1145670 | Respiratory Failure | 1 | BeFree |
| umls:C1260922 | Abnormal breathing | 1 | BeFree |
| umls:C1261473 | Sarcoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1969833 | COPD, Severe Early-Onset | 1 | BeFree |
| umls:C3539909 | Allergic disposition | 1 | BeFree |
| umls:C3665444 | Neutrophilia (disorder) | 1 | BeFree |
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