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| TissGeneSummary for LY6K |
 Gene summary |
| Basic gene information | Gene symbol | LY6K |
| Gene name | lymphocyte antigen 6 complex, locus K | |
| Synonyms | CT97|HSJ001348|ly-6K | |
| Cytomap | UCSC genome browser: 8q24.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001160354.1, NM_001160355.1,NM_017527.3, | |
| Description | cancer/testis antigen 97lymphocyte antigen 6K | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 615093 | |
| HGNC : HGNC | ||
| HPRD : 17457 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LY6K | |
| BioGPS: 54742 | ||
| Pathway | NCI Pathway Interaction Database: LY6K | |
| KEGG: LY6K | ||
| REACTOME: LY6K | ||
| Pathway Commons: LY6K | ||
| Context | iHOP: LY6K | |
| ligand binding site mutation search in PubMed: LY6K | ||
| UCL Cancer Institute: LY6K | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixSkinTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCSKCMTGCT | |
| Reference showing the relevant tissue of LY6K | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for LY6K |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -3.382947998 | -1.330535498 | -2.0524125 | 1.08E-07 | 6.47E-07 |
| LUAD | 0.256825493 | -1.800736576 | 2.057562069 | 1.87E-06 | 6.00E-06 |
| LUSC | 1.903211193 | -2.047967238 | 3.951178431 | 2.39E-22 | 3.74E-21 |
| HNSC | 3.274560578 | 1.200630345 | 2.073930233 | 1.95E-10 | 3.72E-09 |
| KIRC | -2.417369526 | -0.722491748 | -1.694877778 | 3.91E-12 | 1.58E-11 |
| KICH | -0.964533748 | 0.410650252 | -1.375184 | 0.0174 | 0.029774534 |
| PRAD | -2.038060979 | -0.644539825 | -1.393521154 | 0.000398 | 0.001438577 |
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| TissGene-miRNA for LY6K |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for LY6K |
| TissGeneSNV for LY6K |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R119C | SKCM | 2 |
| p.G141S | SKCM | 1 |
| p.V68I | UCEC | 1 |
| p.K192T | UCEC | 1 |
| p.P165T | UCEC | 1 |
| p.R24S | LUAD | 1 |
| p.R76C | LUAD | 1 |
| p.A82V | READ | 1 |
| p.S188L | BRCA | 1 |
| p.D81N | SKCM | 1 |
| p.R77H | THYM | 1 |
| p.E107D | UCEC | 1 |
| p.V126I | UCEC | 1 |
| p.M140I | SKCM | 1 |
| p.A159T | LGG | 1 |
| p.L21M | STAD | 1 |
| p.Q103* | SKCM | 1 |
| p.D109N | READ | 1 |
| p.L75F | SKCM | 1 |
| p.G161S | LUAD | 1 |
| p.Y120C | STAD | 1 |
| p.R48K | SKCM | 1 |
| p.R26Q | SKCM | 1 |
| p.F133C | CESC | 1 |
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| TissGeneCNV for LY6K |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for LY6K |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for LY6K |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| LY6K, UBC (tumor) | LY6K, UBC (normal) |
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| COAD (tumor) | COAD (normal) |
| LY6K, UBC (tumor) | LY6K, UBC (normal) |
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| HNSC (tumor) | HNSC (normal) |
| LY6K, UBC (tumor) | LY6K, UBC (normal) |
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| KICH (tumor) | KICH (normal) |
| LY6K, UBC (tumor) | LY6K, UBC (normal) |
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| KIRC (tumor) | KIRC (normal) |
| LY6K, UBC (tumor) | LY6K, UBC (normal) |
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| KIRP (tumor) | KIRP (normal) |
| LY6K, UBC (tumor) | LY6K, UBC (normal) |
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| LIHC (tumor) | LIHC (normal) |
| LY6K, UBC (tumor) | LY6K, UBC (normal) |
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| LUAD (tumor) | LUAD (normal) |
| LY6K, UBC (tumor) | LY6K, UBC (normal) |
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| LUSC (tumor) | LUSC (normal) |
| LY6K, UBC (tumor) | LY6K, UBC (normal) |
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| PRAD (tumor) | PRAD (normal) |
| LY6K, UBC (tumor) | LY6K, UBC (normal) |
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| STAD (tumor) | STAD (normal) |
| LY6K, UBC (tumor) | LY6K, UBC (normal) |
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| THCA (tumor) | THCA (normal) |
| LY6K, UBC (tumor) | LY6K, UBC (normal) |
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| TissGeneProg for LY6K |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for LY6K |
| TissGeneDrug for LY6K |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for LY6K |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 2 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 2 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 2 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
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