TissGeneSummary for PPEF1 |
Gene summary |
Basic gene information | Gene symbol | PPEF1 |
Gene name | protein phosphatase, EF-hand calcium binding domain 1 | |
Synonyms | PP7|PPEF|PPP7C|PPP7CA | |
Cytomap | UCSC genome browser: Xp22 | |
Type of gene | protein-coding | |
RefGenes | NM_006240.2, NM_152224.1,NM_152226.1,NM_152223.1,NM_152225.1, | |
Description | protein phosphatase 7, catalytic subunit, alpha isozymeprotein phosphatase with EF calcium-binding domainprotein phosphatase, serine/threonine type, with EF-handsserine/threonine protein phosphatase 7serine/threonine-protein phosphatase 7serine/threo | |
Modification date | 20141207 | |
dbXrefs | MIM : 300109 | |
HGNC : HGNC | ||
Ensembl : ENSG00000086717 | ||
HPRD : 02118 | ||
Vega : OTTHUMG00000021219 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PPEF1 | |
BioGPS: 5475 | ||
Pathway | NCI Pathway Interaction Database: PPEF1 | |
KEGG: PPEF1 | ||
REACTOME: PPEF1 | ||
Pathway Commons: PPEF1 | ||
Context | iHOP: PPEF1 | |
ligand binding site mutation search in PubMed: PPEF1 | ||
UCL Cancer Institute: PPEF1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PPEF1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PPEF1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.741350625 | -2.239883384 | 1.498532759 | 2.21E-08 | 9.50E-08 |
KIRC | -1.425289945 | -3.032224667 | 1.606934722 | 7.87E-14 | 3.65E-13 |
HNSC | -0.603445533 | -3.203689719 | 2.600244186 | 2.68E-14 | 1.51E-12 |
COAD | -1.484230864 | -3.540577018 | 2.056346154 | 9.94E-11 | 1.43E-09 |
BRCA | 1.236846531 | -2.007564872 | 3.244411404 | 8.75E-33 | 1.37E-31 |
LUSC | -0.392450321 | -2.2955464 | 1.903096078 | 3.02E-12 | 1.34E-11 |
BLCA | -1.381054346 | -2.547585925 | 1.166531579 | 0.000461 | 0.003797274 |
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TissGene-miRNA for PPEF1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PPEF1 |
TissGeneSNV for PPEF1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E166D | LUAD | 1 |
p.Q132* | BRCA | 1 |
p.K613M | LUAD | 1 |
p.S87R | READ | 1 |
p.H557P | BRCA | 1 |
p.E550K | THCA | 1 |
p.A136T | LUSC | 1 |
p.K147N | UCEC | 1 |
p.Q58H | THCA | 1 |
p.P104T | SARC | 1 |
p.N651S | UCEC | 1 |
p.P163L | SKCM | 1 |
p.P407L | SKCM | 1 |
p.K304N | THYM | 1 |
p.S100L | UCEC | 1 |
p.K207N | READ | 1 |
p.E248* | BRCA | 1 |
p.D120N | UCEC | 1 |
p.A593V | ESCA | 1 |
p.T246M | CESC | 1 |
p.W26* | UCEC | 1 |
p.G232W | LIHC | 1 |
p.G274S | COAD | 1 |
p.E451D | READ | 1 |
p.T468N | UCEC | 1 |
p.S47C | HNSC | 1 |
p.R484Q | SKCM | 1 |
p.N531S | PRAD | 1 |
p.G379V | LUSC | 1 |
p.K361* | SKCM | 1 |
p.D385H | BLCA | 1 |
p.D608H | CESC | 1 |
p.S625R | TGCT | 1 |
p.R463C | SKCM | 1 |
p.D318H | UCEC | 1 |
p.E408K | BLCA | 1 |
p.Y540H | LUAD | 1 |
p.V588M | GBM | 1 |
p.E488K | THCA | 1 |
p.R12K | SARC | 1 |
p.S423F | BRCA | 1 |
p.D120Y | THYM | 1 |
p.K207N | UCEC | 1 |
p.Y381C | LUAD | 1 |
p.I357L | BRCA | 1 |
p.T15I | BLCA | 1 |
p.D90G | LUSC | 1 |
p.S423P | DLBC | 1 |
p.T43I | HNSC | 1 |
p.C3Y | LUSC | 1 |
p.V481M | LUAD | 1 |
p.R12K | UCEC | 1 |
p.E408D | SKCM | 1 |
p.L597R | UCEC | 1 |
p.R111W | UCEC | 1 |
p.E248X | COAD | 1 |
p.E53K | HNSC | 1 |
p.S527L | SKCM | 1 |
p.Q450* | BLCA | 1 |
p.H137Y | UCEC | 1 |
p.S432N | STAD | 1 |
p.L229M | LUSC | 1 |
p.R484X | KIRC | 1 |
p.T374M | ACC | 1 |
p.Q395K | BRCA | 1 |
p.R484* | KIRC | 1 |
p.S569Y | STAD | 1 |
p.E550K | BLCA | 1 |
p.Q493K | HNSC | 1 |
p.R28Q | CESC | 1 |
p.K151Q | COAD | 1 |
p.E550K | HNSC | 1 |
p.R422Q | SKCM | 1 |
p.H74Q | COAD | 1 |
p.S307Y | UCEC | 1 |
p.S472N | STAD | 1 |
p.A424V | PAAD | 1 |
p.E211D | BLCA | 1 |
p.D102Y | UCEC | 1 |
p.M91I | BRCA | 1 |
p.L143I | UCEC | 1 |
p.D358H | BRCA | 1 |
p.P384S | SKCM | 1 |
p.G379C | LUSC | 1 |
p.A473D | STAD | 1 |
p.R401C | SKCM | 1 |
p.E404* | KIRC | 1 |
p.Y196F | GBM | 1 |
p.F181Y | READ | 1 |
p.R111Q | COAD | 1 |
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TissGeneCNV for PPEF1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PPEF1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AF027977 | PPEF1-PPEF1 | chrX:18725759 | chrX:18725760 |
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TissGeneNet for PPEF1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PPEF1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PPEF1 |
TissGeneDrug for PPEF1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PPEF1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0271091 | Retinoschisis, Juvenile, X-Linked | 1 | BeFree |
umls:C0796085 | Nance-Horan syndrome | 1 | BeFree |