TissGeneSummary for SWT1 |
Gene summary |
Basic gene information | Gene symbol | SWT1 |
Gene name | SWT1 RNA endoribonuclease homolog (S. cerevisiae) | |
Synonyms | C1orf26|HsSwt1 | |
Cytomap | UCSC genome browser: 1q25 | |
Type of gene | protein-coding | |
RefGenes | NM_001105518.1, NM_017673.6, | |
Description | transcriptional protein SWT1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000116668 | ||
HPRD : 10726 | ||
Vega : OTTHUMG00000035390 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SWT1 | |
BioGPS: 54823 | ||
Pathway | NCI Pathway Interaction Database: SWT1 | |
KEGG: SWT1 | ||
REACTOME: SWT1 | ||
Pathway Commons: SWT1 | ||
Context | iHOP: SWT1 | |
ligand binding site mutation search in PubMed: SWT1 | ||
UCL Cancer Institute: SWT1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SWT1 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SWT1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for SWT1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ESCA | hsa-let-7f-5p | MIMAT0000067 | 0.0000047 | -0.32 | 192 |
ESCA | hsa-let-7f-5p | MIMAT0000067 | 0.0000047 | -0.32 | 192 |
ESCA | hsa-let-7f-5p | MIMAT0000067 | 0.0000047 | -0.32 | 192 |
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TissGeneMut for SWT1 |
TissGeneSNV for SWT1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E185* | UCEC | 2 |
p.I848M | READ | 2 |
p.K566M | LIHC | 1 |
p.S260L | COAD | 1 |
p.S330P | PRAD | 1 |
p.R302Q | ESCA | 1 |
p.N515K | BLCA | 1 |
p.M895V | PRAD | 1 |
p.E600* | UCEC | 1 |
p.S49L | CESC | 1 |
p.R656C | STAD | 1 |
p.S595X | READ | 1 |
p.E826D | LUSC | 1 |
p.M367I | LUSC | 1 |
p.L479F | BLCA | 1 |
p.R656C | SKCM | 1 |
p.W206C | LUAD | 1 |
p.H125R | LUSC | 1 |
p.R267T | BLCA | 1 |
p.S92L | BLCA | 1 |
p.I148V | COAD | 1 |
p.R302Q | COAD | 1 |
p.S384L | BLCA | 1 |
p.E598K | SKCM | 1 |
p.L638X | READ | 1 |
p.V450D | UCEC | 1 |
p.S260L | UCEC | 1 |
p.V721L | THYM | 1 |
p.L691I | STAD | 1 |
p.Q775* | SKCM | 1 |
p.R241C | STAD | 1 |
p.G147E | ESCA | 1 |
p.K731N | STAD | 1 |
p.K261M | LUSC | 1 |
p.L73P | COAD | 1 |
p.V582A | COAD | 1 |
p.F403S | PAAD | 1 |
p.R69I | UCEC | 1 |
p.D509Y | READ | 1 |
p.D485Y | PRAD | 1 |
p.D17Y | ESCA | 1 |
p.R751K | THYM | 1 |
p.C492S | LUSC | 1 |
p.Q14E | BLCA | 1 |
p.A658D | ESCA | 1 |
p.V740F | HNSC | 1 |
p.R866C | SKCM | 1 |
p.H495Q | KIRP | 1 |
p.P714S | SKCM | 1 |
p.D772N | COAD | 1 |
p.G727C | LUAD | 1 |
p.P327L | LUAD | 1 |
p.K182N | GBM | 1 |
p.S272R | STAD | 1 |
p.L896F | PRAD | 1 |
p.D824N | SKCM | 1 |
p.D455G | STAD | 1 |
p.N108K | STAD | 1 |
p.N191Y | LUAD | 1 |
p.Q813X | COAD | 1 |
p.Q71H | LIHC | 1 |
p.R432C | SKCM | 1 |
p.E185X | READ | 1 |
p.E11Q | CESC | 1 |
p.L746P | LUAD | 1 |
p.H536R | COAD | 1 |
p.R432L | LUAD | 1 |
p.E726K | SKCM | 1 |
p.R302Q | READ | 1 |
p.C127Y | UCEC | 1 |
p.P550H | PAAD | 1 |
p.Q546H | PAAD | 1 |
p.Q274K | SKCM | 1 |
p.N654D | BLCA | 1 |
p.A804V | STAD | 1 |
p.C892R | KIRC | 1 |
p.R353C | READ | 1 |
p.H623L | LUAD | 1 |
p.E649Q | BLCA | 1 |
p.S379F | BLCA | 1 |
p.P237S | SKCM | 1 |
p.E11D | UCEC | 1 |
p.N700H | UCEC | 1 |
p.F843C | COAD | 1 |
p.G521C | UCEC | 1 |
p.I549V | STAD | 1 |
p.R295W | UCEC | 1 |
p.P747S | SKCM | 1 |
p.T855I | SKCM | 1 |
p.H623Y | UCEC | 1 |
p.A661T | LGG | 1 |
p.Q775X | SKCM | 1 |
p.Y64C | STAD | 1 |
p.S583C | HNSC | 1 |
p.R70K | SKCM | 1 |
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TissGeneCNV for SWT1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SWT1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SWT1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SWT1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SWT1 |
TissGeneDrug for SWT1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SWT1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
umls:C0023487 | Acute Promyelocytic Leukemia | 1 | BeFree |