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| TissGeneSummary for NUP62CL |
 Gene summary |
| Basic gene information | Gene symbol | NUP62CL |
| Gene name | nucleoporin 62kDa C-terminal like | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: Xq22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_017681.2, NR_033676.1, | |
| Description | nucleoporin-62 C-terminal-like protein | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000198088 | ||
| HPRD : 06527 | ||
| Vega : OTTHUMG00000022159 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NUP62CL | |
| BioGPS: 54830 | ||
| Pathway | NCI Pathway Interaction Database: NUP62CL | |
| KEGG: NUP62CL | ||
| REACTOME: NUP62CL | ||
| Pathway Commons: NUP62CL | ||
| Context | iHOP: NUP62CL | |
| ligand binding site mutation search in PubMed: NUP62CL | ||
| UCL Cancer Institute: NUP62CL | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADTGCT | |
| Reference showing the relevant tissue of NUP62CL | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for NUP62CL |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | 0.206266567 | -1.639014683 | 1.84528125 | 2.81E-07 | 6.14E-06 |
| COAD | 1.217135076 | -0.444134154 | 1.661269231 | 5.04E-09 | 4.89E-08 |
| THCA | 0.748957827 | 1.823422234 | -1.074464407 | 3.32E-15 | 4.35E-14 |
| LUAD | 0.338157623 | -1.231013067 | 1.56917069 | 4.22E-14 | 3.85E-13 |
| HNSC | 0.107462715 | -1.00879775 | 1.116260465 | 3.03E-06 | 2.01E-05 |
| LUSC | 0.054673613 | -1.222726387 | 1.2774 | 5.98E-09 | 1.92E-08 |
| KICH | -0.253634308 | 1.588129692 | -1.841764 | 4.36E-06 | 1.47E-05 |
| BLCA | -0.074046098 | -2.010172413 | 1.936126316 | 0.000621 | 0.004778907 |
| ESCA | 0.60585151 | -1.863112126 | 2.468963636 | 1.18E-05 | 0.001009354 |
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| TissGene-miRNA for NUP62CL |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for NUP62CL |
| TissGeneSNV for NUP62CL |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E24* | UCEC | 1 |
| p.P70L | SKCM | 1 |
| p.I177T | COAD | 1 |
| p.T24K | LUSC | 1 |
| p.E55K | SKCM | 1 |
| p.T37A | LIHC | 1 |
| p.Q91H | SKCM | 1 |
| p.A104G | GBM | 1 |
| p.R117C | SKCM | 1 |
| p.S9Y | UCEC | 1 |
| p.W52* | UCEC | 1 |
| p.L57F | SKCM | 1 |
| p.E172G | LIHC | 1 |
| p.N112K | KIRC | 1 |
| p.A182E | LUAD | 1 |
| p.H107Y | SKCM | 1 |
| p.A99T | UCEC | 1 |
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| TissGeneCNV for NUP62CL |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for NUP62CL |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for NUP62CL |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| NUP62CL, HNF4A, ELAVL1, OGT (tumor) | NUP62CL, HNF4A, ELAVL1, OGT (normal) |
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| COAD (tumor) | COAD (normal) |
| NUP62CL, HNF4A, ELAVL1, OGT (tumor) | NUP62CL, HNF4A, ELAVL1, OGT (normal) |
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| HNSC (tumor) | HNSC (normal) |
| NUP62CL, HNF4A, ELAVL1, OGT (tumor) | NUP62CL, HNF4A, ELAVL1, OGT (normal) |
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| KICH (tumor) | KICH (normal) |
| NUP62CL, HNF4A, ELAVL1, OGT (tumor) | NUP62CL, HNF4A, ELAVL1, OGT (normal) |
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| KIRC (tumor) | KIRC (normal) |
| NUP62CL, HNF4A, ELAVL1, OGT (tumor) | NUP62CL, HNF4A, ELAVL1, OGT (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| NUP62CL, HNF4A, ELAVL1, OGT (tumor) | NUP62CL, HNF4A, ELAVL1, OGT (normal) |
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| LIHC (tumor) | LIHC (normal) |
| NUP62CL, HNF4A, ELAVL1, OGT (tumor) | NUP62CL, HNF4A, ELAVL1, OGT (normal) |
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| LUAD (tumor) | LUAD (normal) |
| NUP62CL, HNF4A, ELAVL1, OGT (tumor) | NUP62CL, HNF4A, ELAVL1, OGT (normal) |
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| LUSC (tumor) | LUSC (normal) |
| NUP62CL, HNF4A, ELAVL1, OGT (tumor) | NUP62CL, HNF4A, ELAVL1, OGT (normal) |
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| PRAD (tumor) | PRAD (normal) |
| NUP62CL, HNF4A, ELAVL1, OGT (tumor) | NUP62CL, HNF4A, ELAVL1, OGT (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| NUP62CL, HNF4A, ELAVL1, OGT (tumor) | NUP62CL, HNF4A, ELAVL1, OGT (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| NUP62CL, HNF4A, ELAVL1, OGT (tumor) | NUP62CL, HNF4A, ELAVL1, OGT (normal) |
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| TissGeneProg for NUP62CL |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for NUP62CL |
| TissGeneDrug for NUP62CL |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for NUP62CL |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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