TissGeneSummary for ST7L |
Gene summary |
Basic gene information | Gene symbol | ST7L |
Gene name | suppression of tumorigenicity 7 like | |
Synonyms | FAM4B|ST7R|STLR | |
Cytomap | UCSC genome browser: 1p13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_017744.4, NM_138727.3,NM_138728.2,NM_138729.3,NM_198327.1, NM_198328.1, | |
Description | ST7-related proteinsuppressor of tumorigenicity 7 protein-liketumor suppressor ST7 like | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000007341 | ||
HPRD : 18112 | ||
Vega : OTTHUMG00000011753 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ST7L | |
BioGPS: 54879 | ||
Pathway | NCI Pathway Interaction Database: ST7L | |
KEGG: ST7L | ||
REACTOME: ST7L | ||
Pathway Commons: ST7L | ||
Context | iHOP: ST7L | |
ligand binding site mutation search in PubMed: ST7L | ||
UCL Cancer Institute: ST7L | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ST7L | ||
Description by TissGene annotations | Cancer gene TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ST7L |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -0.455840343 | 0.708711657 | -1.164552 | 1.97E-09 | 1.17E-08 |
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TissGene-miRNA for ST7L |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ST7L |
TissGeneSNV for ST7L |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.I267M | UCEC | 2 |
p.F519C | UCEC | 1 |
p.N330S | SKCM | 1 |
p.E169* | UCEC | 1 |
p.E322* | UCEC | 1 |
p.P473L | STAD | 1 |
p.L417V | UCEC | 1 |
p.D553A | STAD | 1 |
p.P471L | LIHC | 1 |
p.A438V | LIHC | 1 |
p.A406T | UCEC | 1 |
p.L202* | SKCM | 1 |
p.R168K | HNSC | 1 |
p.G93E | SKCM | 1 |
p.H281Y | STAD | 1 |
p.G6L | BLCA | 1 |
p.P471T | UCEC | 1 |
p.P21S | SKCM | 1 |
p.P471L | SKCM | 1 |
p.R451L | PAAD | 1 |
p.F194I | SKCM | 1 |
p.E230A | UCEC | 1 |
p.G6V | BLCA | 1 |
p.E341Q | LUAD | 1 |
p.A253T | LGG | 1 |
p.G571D | DLBC | 1 |
p.S75L | UCEC | 1 |
p.Q272H | DLBC | 1 |
p.D435N | KIRC | 1 |
p.E333K | KIRP | 1 |
p.P325S | KIRC | 1 |
p.K374T | STAD | 1 |
p.A440G | LUAD | 1 |
p.E99X | SKCM | 1 |
p.P136L | SKCM | 1 |
p.E244K | BLCA | 1 |
p.F195S | THYM | 1 |
p.V7M | READ | 1 |
p.L202X | SKCM | 1 |
p.E99* | SKCM | 1 |
p.L446I | PAAD | 1 |
p.E560K | LGG | 1 |
p.V400M | STAD | 1 |
p.G6R | BLCA | 1 |
p.A263T | COAD | 1 |
p.H468Y | COAD | 1 |
p.I250N | LUAD | 1 |
p.N142K | SKCM | 1 |
p.Y170C | CHOL | 1 |
p.R203C | COAD | 1 |
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TissGeneCNV for ST7L |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ST7L |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DA313048 | ST7L-MYO5A | chr1:113161774 | chr15:52689578 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-A1-A0SH-01A | CDC27-ST7L | Out-of-frame | Chr17:45266512 | Chr1:113143470 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0CT-01A | ST7L-PRPF6 | Out-of-frame | Chr1:113153463 | Chr20:62616260 |
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TissGeneNet for ST7L |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ST7L |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ST7L |
TissGeneDrug for ST7L |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ST7L |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |