TissGeneSummary for C2orf42 |
Gene summary |
Basic gene information | Gene symbol | C2orf42 |
Gene name | chromosome 2 open reading frame 42 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_017880.1, | |
Description | uncharacterized protein C2orf42 | |
Modification date | 20141215 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000115998 | ||
HPRD : 07927 | ||
Vega : OTTHUMG00000129642 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C2orf42 | |
BioGPS: 54980 | ||
Pathway | NCI Pathway Interaction Database: C2orf42 | |
KEGG: C2orf42 | ||
REACTOME: C2orf42 | ||
Pathway Commons: C2orf42 | ||
Context | iHOP: C2orf42 | |
ligand binding site mutation search in PubMed: C2orf42 | ||
UCL Cancer Institute: C2orf42 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C2orf42 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C2orf42 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | 0.436391625 | 1.654895625 | -1.218504 | 1.62E-16 | 4.82E-15 |
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TissGene-miRNA for C2orf42 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C2orf42 |
TissGeneSNV for C2orf42 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S342L | SKCM | 2 |
p.L110P | LIHC | 1 |
p.R411W | COAD | 1 |
p.R421Q | BLCA | 1 |
p.P528A | STAD | 1 |
p.C193Y | UCEC | 1 |
p.Q350H | KIRC | 1 |
p.S154L | LIHC | 1 |
p.F268L | CESC | 1 |
p.G214V | STAD | 1 |
p.E354G | STAD | 1 |
p.T49I | SKCM | 1 |
p.S231L | READ | 1 |
p.V281A | COAD | 1 |
p.G275_splice | UCEC | 1 |
p.K409N | SKCM | 1 |
p.R464X | ESCA | 1 |
p.I50M | UCEC | 1 |
p.G93R | COAD | 1 |
p.V476E | SARC | 1 |
p.R87Q | KICH | 1 |
p.G69R | BRCA | 1 |
p.I461N | UCEC | 1 |
p.I136M | LUAD | 1 |
p.R221H | STAD | 1 |
p.E483X | DLBC | 1 |
p.K215E | COAD | 1 |
p.I403L | UCEC | 1 |
p.Q109R | STAD | 1 |
p.K9E | BLCA | 1 |
p.T147A | UCEC | 1 |
p.Q462* | SKCM | 1 |
p.S311C | ESCA | 1 |
p.S200N | LIHC | 1 |
p.S119* | BLCA | 1 |
p.G428A | BLCA | 1 |
p.H135Y | STAD | 1 |
p.E451K | BLCA | 1 |
p.S327N | LIHC | 1 |
p.V90M | PRAD | 1 |
p.S311Y | BLCA | 1 |
p.A262T | LGG | 1 |
p.A398T | STAD | 1 |
p.G382D | ESCA | 1 |
p.I107T | LUAD | 1 |
p.R464* | ESCA | 1 |
p.R487C | SKCM | 1 |
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TissGeneCNV for C2orf42 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C2orf42 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | OV | TCGA-24-1423-01A | AAK1-C2orf42 | Out-of-frame | Chr2:69783992 | Chr2:70377696 |
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TissGeneNet for C2orf42 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C2orf42 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C2orf42 |
TissGeneDrug for C2orf42 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C2orf42 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |