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| TissGeneSummary for MARC2 |
 Gene summary |
| Basic gene information | Gene symbol | MARC2 |
| Gene name | mitochondrial amidoxime reducing component 2 | |
| Synonyms | MOSC2 | |
| Cytomap | UCSC genome browser: 1q41 | |
| Type of gene | protein-coding | |
| RefGenes | NM_017898.3, | |
| Description | MOCO sulphurase C-terminal domain containing 2MOSC domain-containing protein 2, mitochondrialmoco sulfurase C-terminal domain-containing protein 2molybdenum cofactor sulfurase C-terminal domain-containing protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 614127 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000117791 | ||
| HPRD : 08628 | ||
| Vega : OTTHUMG00000037354 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MARC2 | |
| BioGPS: 54996 | ||
| Pathway | NCI Pathway Interaction Database: MARC2 | |
| KEGG: MARC2 | ||
| REACTOME: MARC2 | ||
| Pathway Commons: MARC2 | ||
| Context | iHOP: MARC2 | |
| ligand binding site mutation search in PubMed: MARC2 | ||
| UCL Cancer Institute: MARC2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of MARC2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0042126 | nitrate metabolic process | 20861021 | GO:0055114 | oxidation-reduction process | 20861021 | GO:0042126 | nitrate metabolic process | 20861021 | GO:0055114 | oxidation-reduction process | 20861021 |
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| TissGeneExp for MARC2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for MARC2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MARC2 |
| TissGeneSNV for MARC2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P301S | LGG | 1 |
| p.R333Q | BLCA | 1 |
| p.Y317D | LUSC | 1 |
| p.L172M | LUAD | 1 |
| p.S142L | BLCA | 1 |
| p.N185I | COAD | 1 |
| p.D300N | HNSC | 1 |
| p.E228G | UCS | 1 |
| p.P301A | LUSC | 1 |
| p.E234G | COAD | 1 |
| p.L293P | STAD | 1 |
| p.R237M | LUAD | 1 |
| p.A268T | UCEC | 1 |
| p.E183* | LUAD | 1 |
| p.L145V | LUAD | 1 |
| p.T169I | LUAD | 1 |
| p.A205V | ESCA | 1 |
| p.Q200* | BLCA | 1 |
| p.R178K | COAD | 1 |
| p.D208Y | UCEC | 1 |
| p.R42C | BLCA | 1 |
| p.M227I | SKCM | 1 |
| p.Y118C | LGG | 1 |
| p.F168L | COAD | 1 |
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| TissGeneCNV for MARC2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MARC2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF770570 | MACF1-MARC2 | chr1:39796224 | chr1:220941199 | |
| Chimerdb3.0 | ChiTaRs | NA | BX102201 | PLCD4-MARC2 | chr2:219489169 | chr1:220932026 |
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| TissGeneNet for MARC2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for MARC2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MARC2 |
| TissGeneDrug for MARC2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MARC2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0010034 | Corneal Diseases | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0153629 | Malignant neoplasm of cornea | 1 | GAD |
| umls:C0154026 | Benign neoplasm of cornea | 1 | GAD |
| umls:C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
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