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| TissGeneSummary for ACPP |
 Gene summary |
| Basic gene information | Gene symbol | ACPP |
| Gene name | acid phosphatase, prostate | |
| Synonyms | 5'-NT|ACP-3|ACP3 | |
| Cytomap | UCSC genome browser: 3q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001099.4, NM_001134194.1,NM_001292037.1, | |
| Description | 5'-nucleotidaseTMPaseecto-5'-nucleotidaseprostatic acid phosphataseprostatic acid phosphotasethiamine monophosphatase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 171790 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000014257 | ||
| HPRD : 01378 | ||
| Vega : OTTHUMG00000159650 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ACPP | |
| BioGPS: 55 | ||
| Pathway | NCI Pathway Interaction Database: ACPP | |
| KEGG: ACPP | ||
| REACTOME: ACPP | ||
| Pathway Commons: ACPP | ||
| Context | iHOP: ACPP | |
| ligand binding site mutation search in PubMed: ACPP | ||
| UCL Cancer Institute: ACPP | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of ACPP | An efficient method for native protein purification in the selected range from prostate cancer tissue digests. Ahmad R, Nicora CD, Shukla AK, Smith RD, Qian WJ, Liu AY. Chin Clin Oncol. 2016 Dec;5(6):78. doi: 10.21037/cco.2016.12.03. (pmid:28061542) go to article | |
| Description by TissGene annotations | Fused withOncogene Fused withTSGene Protective TissGene in OS Protective TissGene in RFS Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0046085 | adenosine metabolic process | 18940592 | GO:0046085 | adenosine metabolic process | 18940592 |
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| TissGeneExp for ACPP |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | 0.970062063 | 3.063799272 | -2.093737209 | 7.81E-08 | 7.88E-07 |
| KICH | -0.619644821 | 3.419703179 | -4.039348 | 1.19E-09 | 7.33E-09 |
| KIRC | -2.528022821 | 3.473270235 | -6.001293056 | 1.33E-58 | 5.96E-56 |
| KIRP | -3.007469696 | 3.574730304 | -6.5822 | 1.50E-24 | 1.87E-22 |
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| TissGene-miRNA for ACPP |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ACPP |
| TissGeneSNV for ACPP |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E321K | BLCA | 3 |
| p.R43W | BRCA | 2 |
| p.T335M | LIHC | 1 |
| p.R405C | LGG | 1 |
| p.D211N | UCEC | 1 |
| p.M271T | UCEC | 1 |
| p.E237* | BLCA | 1 |
| p.E176K | SKCM | 1 |
| p.G192E | SKCM | 1 |
| p.P54S | SKCM | 1 |
| p.Y214X | SKCM | 1 |
| p.A227T | SKCM | 1 |
| p.T275S | LGG | 1 |
| p.S294G | STAD | 1 |
| p.P309H | THYM | 1 |
| p.R28L | BRCA | 1 |
| p.S348I | LUAD | 1 |
| p.G45R | SKCM | 1 |
| p.D301E | ESCA | 1 |
| p.K193R | LIHC | 1 |
| p.E254Q | HNSC | 1 |
| p.E338V | LIHC | 1 |
| p.Q77L | LIHC | 1 |
| p.H78Y | PRAD | 1 |
| p.K87N | BRCA | 1 |
| p.E170Q | LUAD | 1 |
| p.G305R | BLCA | 1 |
| p.K91N | UCEC | 1 |
| p.D151Y | BLCA | 1 |
| p.E358D | LUAD | 1 |
| p.P54T | HNSC | 1 |
| p.R28L | LUAD | 1 |
| p.R405P | LIHC | 1 |
| p.S174L | BLCA | 1 |
| p.Y214* | SKCM | 1 |
| p.R43W | SKCM | 1 |
| p.P162S | LUAD | 1 |
| p.P147S | SKCM | 1 |
| p.P126S | STAD | 1 |
| p.G128D | SKCM | 1 |
| p.Y331C | UCS | 1 |
| p.C372F | OV | 1 |
| p.M397I | SKCM | 1 |
| p.G192X | THYM | 1 |
| p.E229K | BLCA | 1 |
| p.L202F | ACC | 1 |
| p.P125S | SKCM | 1 |
| p.P309H | LUAD | 1 |
| p.R405H | UCEC | 1 |
| p.S348R | SARC | 1 |
| p.G305R | SKCM | 1 |
| p.R28* | SKCM | 1 |
| p.L181P | COAD | 1 |
| p.L26P | COAD | 1 |
| p.R47Q | SKCM | 1 |
| p.L307F | SKCM | 1 |
| p.A386T | ESCA | 1 |
| p.E76D | STAD | 1 |
| p.T385I | LUAD | 1 |
| p.Q276H | BLCA | 1 |
| p.V262F | BRCA | 1 |
| p.R105Q | SKCM | 1 |
| p.Q297R | ESCA | 1 |
| p.R105* | LGG | 1 |
| p.P57L | SKCM | 1 |
| p.I141V | LGG | 1 |
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| TissGeneCNV for ACPP |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ACPP |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BE768768 | ACPP-PAFAH1B1 | chr3:132077108 | chr17:2578664 | |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-WW-A8ZI-01A | ACPP-ZNF462 | 5'UTR-5'UTR | chr3:132036420 | chr9:109685634 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6366-01A | ACPP-MYC | In-Frame | chr3:132051188 | chr8:128750493 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-J4-A6G3-01A | ACPP-AXL | In-Frame | chr3:132075699 | chr19:41748787 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-7233-01A | ACPP-SAFB2 | In-Frame | chr3:132036420 | chr19:5616346 |
| Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-AX-A3FX-01A | ACPP-GK5 | In-Frame | chr3:132069181 | chr3:141889237 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-HC-7077-01A | ACPP-TMPRSS2 | In-Frame | chr3:132050576 | chr21:42843693 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-HC-7077-01A | ACPP-TMPRSS2 | In-Frame | chr3:132050814 | chr21:42843184 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-V1-A9O9-01A | ACPP-ATP2C1 | In-Frame | chr3:132036419 | chr3:130649259 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-V1-A9O9-01A | ATP2C1-ACPP | In-Frame | chr3:130675022 | chr3:132041470 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-HC-7211-01A | ACPP-SKIL | In-Frame | chr3:132036419 | chr3:170101818 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-HC-7233-01A | ACPP-SAFB2 | In-Frame | chr3:132036419 | chr19:5616345 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-G9-6366-01A | ACPP-CASC11 | Out-of-Frame | chr3:132051187 | chr8:128746200 |
| TCGAfusionPortal | PRADA | PRAD | TCGA-EJ-7125-01A | RPLP2-ACPP | 3UTR-5UTR | Chr11:812874 | Chr3:132036211 |
| TCGAfusionPortal | PRADA | PRAD | TCGA-G9-6367-01A | PKM2-ACPP | 3UTR-5UTR | Chr15:72491370 | Chr3:132036250 |
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| TissGeneNet for ACPP |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ACPP, UBC, ONECUT1, ERBB2, SHBG (tumor) | ACPP, UBC, ONECUT1, ERBB2, SHBG (normal) |
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| COAD (tumor) | COAD (normal) |
| ACPP, UBC, ONECUT1, ERBB2, SHBG (tumor) | ACPP, UBC, ONECUT1, ERBB2, SHBG (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ACPP, UBC, ONECUT1, ERBB2, SHBG (tumor) | ACPP, UBC, ONECUT1, ERBB2, SHBG (normal) |
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| KICH (tumor) | KICH (normal) |
| ACPP, UBC, ONECUT1, ERBB2, SHBG (tumor) | ACPP, UBC, ONECUT1, ERBB2, SHBG (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ACPP, UBC, ONECUT1, ERBB2, SHBG (tumor) | ACPP, UBC, ONECUT1, ERBB2, SHBG (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ACPP, UBC, ONECUT1, ERBB2, SHBG (tumor) | ACPP, UBC, ONECUT1, ERBB2, SHBG (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| ACPP, UBC, ONECUT1, ERBB2, SHBG (tumor) | ACPP, UBC, ONECUT1, ERBB2, SHBG (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| ACPP, UBC, ONECUT1, ERBB2, SHBG (tumor) | ACPP, UBC, ONECUT1, ERBB2, SHBG (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| ACPP, UBC, ONECUT1, ERBB2, SHBG (tumor) | ACPP, UBC, ONECUT1, ERBB2, SHBG (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| ACPP, UBC, ONECUT1, ERBB2, SHBG (tumor) | ACPP, UBC, ONECUT1, ERBB2, SHBG (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| ACPP, UBC, ONECUT1, ERBB2, SHBG (tumor) | ACPP, UBC, ONECUT1, ERBB2, SHBG (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| ACPP, UBC, ONECUT1, ERBB2, SHBG (tumor) | ACPP, UBC, ONECUT1, ERBB2, SHBG (normal) |
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| TissGeneProg for ACPP |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ACPP |
| TissGeneDrug for ACPP |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB06688 | Sipuleucel-T | Antagonist|Inhibitory immune response | Biotech | Approved |
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| TissGeneDisease for ACPP |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0600139 | Prostate carcinoma | 22 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 18 | BeFree,MGD |
| umls:C0019693 | HIV Infections | 4 | BeFree |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 4 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 4 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 4 | BeFree,LHGDN |
| umls:C0002878 | Anemia, Hemolytic | 3 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0010674 | Cystic Fibrosis | 3 | BeFree |
| umls:C0023418 | leukemia | 3 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
| umls:C0033581 | prostatitis | 3 | BeFree,LHGDN |
| umls:C0034186 | Pyelonephritis | 3 | BeFree |
| umls:C0150055 | Chronic pain | 3 | BeFree |
| umls:C0343401 | MRSA - Methicillin resistant Staphylococcus aureus infection | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0001418 | Adenocarcinoma | 2 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
| umls:C0034050 | Pulmonary Alveolar Proteinosis | 2 | BeFree |
| umls:C0206708 | Cervical Intraepithelial Neoplasia | 2 | BeFree |
| umls:C0221036 | Acrodermatitis enteropathica | 2 | BeFree |
| umls:C0520575 | Acute pyelonephritis | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C0003864 | Arthritis | 1 | BeFree |
| umls:C0006144 | Breast Cyst | 1 | LHGDN |
| umls:C0006145 | Breast Diseases | 1 | LHGDN |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0015230 | Exanthema | 1 | BeFree |
| umls:C0017551 | Gilbert Disease (disorder) | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0018801 | Heart failure | 1 | BeFree |
| umls:C0018802 | Congestive heart failure | 1 | BeFree |
| umls:C0020538 | Hypertensive disease | 1 | BeFree |
| umls:C0026936 | Mycoplasma Infections | 1 | BeFree |
| umls:C0027796 | Neuralgia | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042341 | Varicocele | 1 | BeFree |
| umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
| umls:C0184567 | Acute onset pain | 1 | BeFree |
| umls:C0220697 | POLYDACTYLY, POSTAXIAL | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0334276 | Adenocarcinoma in Situ | 1 | BeFree |
| umls:C0334660 | Angioendotheliomatosis | 1 | BeFree |
| umls:C0343641 | Human papilloma virus infection | 1 | BeFree |
| umls:C0376545 | Hematologic Neoplasms | 1 | BeFree |
| umls:C0398686 | Primary immune deficiency disorder | 1 | BeFree |
| umls:C0520572 | Enzymopathy | 1 | BeFree |
| umls:C0598935 | Tumor Initiation | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0751214 | Hyperalgesia, Thermal | 1 | BeFree |
| umls:C0848332 | Spots on skin | 1 | BeFree |
| umls:C0855095 | Small Lymphocytic Lymphoma | 1 | BeFree |
| umls:C0920646 | Renal ischaemia | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C2936719 | Mechanical Allodynia | 1 | BeFree |
| umls:C3495559 | Juvenile arthritis | 1 | CTD_human |
| umls:C3714542 | Lymphoma, Diffuse | 1 | BeFree |
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