TissGeneSummary for ZWILCH |
Gene summary |
Basic gene information | Gene symbol | ZWILCH |
Gene name | zwilch kinetochore protein | |
Synonyms | KNTC1AP|hZwilch | |
Cytomap | UCSC genome browser: 15q22.31 | |
Type of gene | protein-coding | |
RefGenes | NR_003105.1, NM_001287821.1,NM_001287822.1,NM_001287823.1,NM_017975.4, | |
Description | Zwilch, kinetochore associated, homologhomolog of Drosophila Zwilchprotein zwilch homolog | |
Modification date | 20141207 | |
dbXrefs | MIM : 609984 | |
HGNC : HGNC | ||
Ensembl : ENSG00000174442 | ||
HPRD : 07640 | ||
Vega : OTTHUMG00000133194 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZWILCH | |
BioGPS: 55055 | ||
Pathway | NCI Pathway Interaction Database: ZWILCH | |
KEGG: ZWILCH | ||
REACTOME: ZWILCH | ||
Pathway Commons: ZWILCH | ||
Context | iHOP: ZWILCH | |
ligand binding site mutation search in PubMed: ZWILCH | ||
UCL Cancer Institute: ZWILCH | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ZWILCH | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for ZWILCH |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 2.369656448 | 0.475738801 | 1.893917647 | 1.24E-31 | 7.35E-30 |
BRCA | 1.950740762 | 0.846576727 | 1.104164035 | 1.87E-34 | 3.45E-33 |
LUAD | 1.484966049 | 0.364212601 | 1.120753448 | 1.18E-18 | 1.78E-17 |
BLCA | 2.315102166 | 0.786354797 | 1.528747368 | 1.64E-08 | 1.52E-06 |
STAD | 2.007738679 | 0.713863679 | 1.293875 | 1.84E-09 | 1.29E-07 |
ESCA | 2.546334702 | 0.96461652 | 1.581718182 | 3.85E-06 | 0.0007784 |
Top |
TissGene-miRNA for ZWILCH |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for ZWILCH |
TissGeneSNV for ZWILCH |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A220T | UCEC | 1 |
p.A8S | LUSC | 1 |
p.I496L | BRCA | 1 |
p.W286X | STAD | 1 |
p.A331V | HNSC | 1 |
p.I535M | COAD | 1 |
p.E10Q | LUAD | 1 |
p.A226T | PAAD | 1 |
p.S490Y | BLCA | 1 |
p.D347N | CESC | 1 |
p.D381H | BLCA | 1 |
p.G571C | LUAD | 1 |
p.K176T | COAD | 1 |
p.D456N | LUSC | 1 |
p.R259G | OV | 1 |
p.G311V | LIHC | 1 |
p.T324A | OV | 1 |
p.W286* | STAD | 1 |
p.N177K | COAD | 1 |
p.L182I | UCEC | 1 |
p.M582V | KIRP | 1 |
p.V64A | LIHC | 1 |
p.F578L | UCEC | 1 |
p.I361N | BRCA | 1 |
p.Q524* | BLCA | 1 |
p.S82C | BRCA | 1 |
p.R259T | CESC | 1 |
p.W150L | SARC | 1 |
p.P416S | OV | 1 |
p.G104A | LUAD | 1 |
p.R379H | LIHC | 1 |
p.P528S | LUAD | 1 |
p.S454* | BLCA | 1 |
p.R192I | UCEC | 1 |
p.A349V | THYM | 1 |
p.D144G | COAD | 1 |
p.G152* | LUAD | 1 |
p.P503S | SKCM | 1 |
p.D235N | UCEC | 1 |
p.A224V | PRAD | 1 |
p.Q375L | SKCM | 1 |
p.A224V | STAD | 1 |
p.S344G | COAD | 1 |
p.E183K | HNSC | 1 |
p.F271C | UCEC | 1 |
p.Y523H | STAD | 1 |
p.Y168H | LUAD | 1 |
p.E257D | SARC | 1 |
p.S294F | SKCM | 1 |
p.R15H | SKCM | 1 |
p.Q300H | BRCA | 1 |
p.N21D | UCEC | 1 |
Top |
TissGeneCNV for ZWILCH |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for ZWILCH |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-E9-A22G-01A | ZWILCH-ATG16L2 | CDS-3UTR | Chr15:66825351 | Chr11:72553662 |
Top |
TissGeneNet for ZWILCH |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for ZWILCH |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for ZWILCH |
TissGeneDrug for ZWILCH |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for ZWILCH |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree,GAD |
umls:C0043094 | Weight Gain | 1 | CTD_human |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |