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| TissGeneSummary for ZCWPW1 |
 Gene summary |
| Basic gene information | Gene symbol | ZCWPW1 |
| Gene name | zinc finger, CW type with PWWP domain 1 | |
| Synonyms | ZCW1 | |
| Cytomap | UCSC genome browser: 7q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001258008.1, NM_017984.4, | |
| Description | zinc finger CW-type PWWP domain protein 1zinc finger, CW-type with PWWP domain 1 | |
| Modification date | 20141211 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000078487 | ||
| HPRD : 15706 | ||
| Vega : OTTHUMG00000159537 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZCWPW1 | |
| BioGPS: 55063 | ||
| Pathway | NCI Pathway Interaction Database: ZCWPW1 | |
| KEGG: ZCWPW1 | ||
| REACTOME: ZCWPW1 | ||
| Pathway Commons: ZCWPW1 | ||
| Context | iHOP: ZCWPW1 | |
| ligand binding site mutation search in PubMed: ZCWPW1 | ||
| UCL Cancer Institute: ZCWPW1 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of ZCWPW1 | ||
| Description by TissGene annotations | TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ZCWPW1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for ZCWPW1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ZCWPW1 |
| TissGeneSNV for ZCWPW1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S277L | BLCA | 2 |
| p.S368Y | UCEC | 1 |
| p.T131I | CESC | 1 |
| p.Q238H | UCEC | 1 |
| p.A521G | LIHC | 1 |
| p.E457K | CESC | 1 |
| p.E176K | SKCM | 1 |
| p.A134V | CHOL | 1 |
| p.G43W | GBM | 1 |
| p.R566K | PRAD | 1 |
| p.E130Q | PRAD | 1 |
| p.H513L | BRCA | 1 |
| p.N535S | ESCA | 1 |
| p.E336* | UCEC | 1 |
| p.R477C | SKCM | 1 |
| p.V602F | BLCA | 1 |
| p.Q109E | THYM | 1 |
| p.E564X | READ | 1 |
| p.G629R | GBM | 1 |
| p.P262S | SKCM | 1 |
| p.K62R | LUAD | 1 |
| p.S349F | READ | 1 |
| p.R17T | BLCA | 1 |
| p.E460K | SKCM | 1 |
| p.E598D | ESCA | 1 |
| p.T155I | THCA | 1 |
| p.A411T | CESC | 1 |
| p.V291M | LUAD | 1 |
| p.I169M | PAAD | 1 |
| p.S28I | STAD | 1 |
| p.S97A | LGG | 1 |
| p.S198Y | BRCA | 1 |
| p.P373Q | SKCM | 1 |
| p.G532D | SKCM | 1 |
| p.E587K | SKCM | 1 |
| p.E459K | CESC | 1 |
| p.E630K | BLCA | 1 |
| p.I416V | BLCA | 1 |
| p.L112V | BRCA | 1 |
| p.C32Y | PAAD | 1 |
| p.N375K | CESC | 1 |
| p.S560L | LUSC | 1 |
| p.E458D | STAD | 1 |
| p.W267* | SKCM | 1 |
| p.S349F | SKCM | 1 |
| p.A644V | PRAD | 1 |
| p.S131* | BRCA | 1 |
| p.A580V | COAD | 1 |
| p.Q113R | KIRP | 1 |
| p.W371C | ESCA | 1 |
| p.H236Y | LUAD | 1 |
| p.K570N | UCEC | 1 |
| p.P15S | SKCM | 1 |
| p.C253W | BRCA | 1 |
| p.P523S | SKCM | 1 |
| p.W372C | ESCA | 1 |
| p.E95X | ESCA | 1 |
| p.P15R | GBM | 1 |
| p.R438K | SKCM | 1 |
| p.A134V | UCEC | 1 |
| p.W267X | SKCM | 1 |
| p.R228Q | BLCA | 1 |
| p.E531K | SKCM | 1 |
| p.R428Q | SKCM | 1 |
| p.Q409* | BLCA | 1 |
| p.V621A | SKCM | 1 |
| p.Q505R | COAD | 1 |
| p.R623T | BLCA | 1 |
| p.Q24H | UCEC | 1 |
| p.P475S | CHOL | 1 |
| p.E457D | STAD | 1 |
| p.E412* | LUAD | 1 |
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| TissGeneCNV for ZCWPW1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ZCWPW1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for ZCWPW1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ZCWPW1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ZCWPW1 |
| TissGeneDrug for ZCWPW1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ZCWPW1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0002395 | Alzheimer's Disease | 1 | GWASCAT |
| umls:C0242383 | Age related macular degeneration | 1 | BeFree |
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