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| TissGeneSummary for PIWIL2 |
 Gene summary |
| Basic gene information | Gene symbol | PIWIL2 |
| Gene name | piwi-like RNA-mediated gene silencing 2 | |
| Synonyms | CT80|HILI|PIWIL1L|mili | |
| Cytomap | UCSC genome browser: 8p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001135721.1, NM_018068.3, | |
| Description | 80kDa PIWIL2 short isoformMiwi likecancer/testis antigen 80piwi-like 2piwi-like protein 2piwil2-like protein | |
| Modification date | 20141209 | |
| dbXrefs | MIM : 610312 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000197181 | ||
| HPRD : 11434 | ||
| Vega : OTTHUMG00000097767 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PIWIL2 | |
| BioGPS: 55124 | ||
| Pathway | NCI Pathway Interaction Database: PIWIL2 | |
| KEGG: PIWIL2 | ||
| REACTOME: PIWIL2 | ||
| Pathway Commons: PIWIL2 | ||
| Context | iHOP: PIWIL2 | |
| ligand binding site mutation search in PubMed: PIWIL2 | ||
| UCL Cancer Institute: PIWIL2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of PIWIL2 | ||
| Description by TissGene annotations | Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PIWIL2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -2.207365516 | -0.826640516 | -1.380725 | 1.54E-05 | 6.18E-05 |
| BRCA | -1.013982347 | 0.841994846 | -1.855977193 | 6.77E-20 | 4.77E-19 |
| KICH | -2.557451891 | -1.061343891 | -1.496108 | 3.44E-06 | 1.17E-05 |
| THCA | -1.624418535 | 0.14758316 | -1.772001695 | 1.19E-12 | 1.03E-11 |
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| TissGene-miRNA for PIWIL2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PIWIL2 |
| TissGeneSNV for PIWIL2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G147R | SKCM | 2 |
| p.E115K | SKCM | 2 |
| p.W932* | SKCM | 1 |
| p.R702Q | SARC | 1 |
| p.A396D | PAAD | 1 |
| p.I306N | UCEC | 1 |
| p.Q192* | SKCM | 1 |
| p.E968K | BLCA | 1 |
| p.G753D | HNSC | 1 |
| p.S68Y | STAD | 1 |
| p.R648L | UCEC | 1 |
| p.G52E | BLCA | 1 |
| p.G899S | PRAD | 1 |
| p.E961K | SKCM | 1 |
| p.A513V | SKCM | 1 |
| p.H960D | OV | 1 |
| p.M744I | SKCM | 1 |
| p.P470S | SKCM | 1 |
| p.G753S | HNSC | 1 |
| p.W121L | SKCM | 1 |
| p.A913T | STAD | 1 |
| p.K515N | STAD | 1 |
| p.G147E | SKCM | 1 |
| p.W932X | SKCM | 1 |
| p.R755H | LGG | 1 |
| p.G129W | LUAD | 1 |
| p.P611T | COAD | 1 |
| p.K169T | PAAD | 1 |
| p.D733N | BRCA | 1 |
| p.G553V | LUSC | 1 |
| p.S105F | SKCM | 1 |
| p.T904A | GBM | 1 |
| p.I573S | SKCM | 1 |
| p.S68F | SKCM | 1 |
| p.P693T | CESC | 1 |
| p.L953M | UCEC | 1 |
| p.M847V | STAD | 1 |
| p.E252* | HNSC | 1 |
| p.L285P | READ | 1 |
| p.V851A | UCEC | 1 |
| p.M740I | UCEC | 1 |
| p.R566H | HNSC | 1 |
| p.D559N | SKCM | 1 |
| p.R428H | UCEC | 1 |
| p.G565R | KIRC | 1 |
| p.G565V | HNSC | 1 |
| p.P94S | READ | 1 |
| p.M331I | BLCA | 1 |
| p.A714V | LUSC | 1 |
| p.V125L | KIRC | 1 |
| p.E135V | THYM | 1 |
| p.P943H | STAD | 1 |
| p.M256I | SKCM | 1 |
| p.N423T | HNSC | 1 |
| p.S763N | COAD | 1 |
| p.L719P | LIHC | 1 |
| p.F605L | PAAD | 1 |
| p.Y772C | STAD | 1 |
| p.R341K | SKCM | 1 |
| p.C253W | LUAD | 1 |
| p.S185L | SKCM | 1 |
| p.H929N | LUAD | 1 |
| p.S763R | UCEC | 1 |
| p.R814G | BLCA | 1 |
| p.A662S | ESCA | 1 |
| p.R551H | GBM | 1 |
| p.V22I | BRCA | 1 |
| p.R61K | STAD | 1 |
| p.Q844* | LUAD | 1 |
| p.F258L | BLCA | 1 |
| p.Y906C | HNSC | 1 |
| p.A544T | COAD | 1 |
| p.P639L | SKCM | 1 |
| p.P25S | UCEC | 1 |
| p.R555H | SARC | 1 |
| p.K846N | COAD | 1 |
| p.N522Y | LUAD | 1 |
| p.G46S | LIHC | 1 |
| p.F452L | READ | 1 |
| p.Q853* | HNSC | 1 |
| p.S73F | SKCM | 1 |
| p.E408K | LUAD | 1 |
| p.E620V | BLCA | 1 |
| p.Q242* | SKCM | 1 |
| p.G362S | UCEC | 1 |
| p.G502R | PRAD | 1 |
| p.Q224* | CESC | 1 |
| p.I473V | LUSC | 1 |
| p.E56K | SKCM | 1 |
| p.S787T | LUAD | 1 |
| p.E585K | ESCA | 1 |
| p.G48C | PRAD | 1 |
| p.L352R | COAD | 1 |
| p.Q265E | BLCA | 1 |
| p.R386W | LUAD | 1 |
| p.M500I | BLCA | 1 |
| p.W932L | LUSC | 1 |
| p.R774W | SKCM | 1 |
| p.R572I | UCEC | 1 |
| p.A300T | LGG | 1 |
| p.E56K | PRAD | 1 |
| p.S583Y | UCEC | 1 |
| p.Q834H | UCEC | 1 |
| p.H956Y | UCEC | 1 |
| p.E210K | SKCM | 1 |
| p.P201H | UCEC | 1 |
| p.G661E | SKCM | 1 |
| p.E968K | COAD | 1 |
| p.G276V | THYM | 1 |
| p.L970V | HNSC | 1 |
| p.R428C | SKCM | 1 |
| p.L796F | STAD | 1 |
| p.E135D | SKCM | 1 |
| p.D345G | STAD | 1 |
| p.H905Y | LGG | 1 |
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| TissGeneCNV for PIWIL2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PIWIL2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BX537789 | PIWIL2-VPS54 | chr8:22177254 | chr2:64224684 | |
| Chimerdb3.0 | ChiTaRs | NA | BF061806 | PIWIL2-ROCK2 | chr8:22133991 | chr2:11351915 | |
| Chimerdb3.0 | FusionScan | HNSC | TCGA-CN-4731-01A | PPP3CC-PIWIL2 | In-Frame | chr8:22333137 | chr8:22138632 |
| TCGAfusionPortal | PRADA | HNSC | TCGA-CN-4731-01A | PPP3CC-PIWIL2 | In-frame | Chr8:22333137 | Chr8:22138633 |
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| TissGeneNet for PIWIL2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PIWIL2, HSP90AA1, DDX4, DICER1 (tumor) | PIWIL2, HSP90AA1, DDX4, DICER1 (normal) |
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| COAD (tumor) | COAD (normal) |
| PIWIL2, HSP90AA1, DDX4, DICER1 (tumor) | PIWIL2, HSP90AA1, DDX4, DICER1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PIWIL2, HSP90AA1, DDX4, DICER1 (tumor) | PIWIL2, HSP90AA1, DDX4, DICER1 (normal) |
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| KICH (tumor) | KICH (normal) |
| PIWIL2, HSP90AA1, DDX4, DICER1 (tumor) | PIWIL2, HSP90AA1, DDX4, DICER1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| PIWIL2, HSP90AA1, DDX4, DICER1 (tumor) | PIWIL2, HSP90AA1, DDX4, DICER1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| PIWIL2, HSP90AA1, DDX4, DICER1 (tumor) | PIWIL2, HSP90AA1, DDX4, DICER1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| PIWIL2, HSP90AA1, DDX4, DICER1 (tumor) | PIWIL2, HSP90AA1, DDX4, DICER1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| PIWIL2, HSP90AA1, DDX4, DICER1 (tumor) | PIWIL2, HSP90AA1, DDX4, DICER1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| PIWIL2, HSP90AA1, DDX4, DICER1 (tumor) | PIWIL2, HSP90AA1, DDX4, DICER1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| PIWIL2, HSP90AA1, DDX4, DICER1 (tumor) | PIWIL2, HSP90AA1, DDX4, DICER1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| PIWIL2, HSP90AA1, DDX4, DICER1 (tumor) | PIWIL2, HSP90AA1, DDX4, DICER1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| PIWIL2, HSP90AA1, DDX4, DICER1 (tumor) | PIWIL2, HSP90AA1, DDX4, DICER1 (normal) |
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| TissGeneProg for PIWIL2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PIWIL2 |
| TissGeneDrug for PIWIL2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PIWIL2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0021364 | Male infertility | 2 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0153594 | Malignant neoplasm of testis | 2 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
| umls:C0004509 | Azoospermia | 1 | GAD |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0028960 | Oligospermia | 1 | GAD |
| umls:C0079588 | Ichthyosis, X-Linked | 1 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C1261473 | Sarcoma | 1 | BeFree |
| umls:C1336708 | Testicular Germ Cell Tumor | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
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