TissGeneSummary for NUDT11 |
Gene summary |
Basic gene information | Gene symbol | NUDT11 |
Gene name | nudix (nucleoside diphosphate linked moiety X)-type motif 11 | |
Synonyms | APS1|ASP1|DIPP3b|DIPP3beta|hDIPP3beta | |
Cytomap | UCSC genome browser: Xp11.22 | |
Type of gene | protein-coding | |
RefGenes | NM_018159.3, | |
Description | DIPP-3-betaDIPP3-betadiadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-betadiadenosine hexaphosphate hydrolase (AMP-forming)diphosphoinositol polyphosphate phosphohydrolase 3, betadiphosphoinositol polyphosphate phosphohydrolase 3-betahAps1nucleo | |
Modification date | 20141207 | |
dbXrefs | MIM : 300528 | |
HGNC : HGNC | ||
Ensembl : ENSG00000196368 | ||
HPRD : 06667 | ||
Vega : OTTHUMG00000021531 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NUDT11 | |
BioGPS: 55190 | ||
Pathway | NCI Pathway Interaction Database: NUDT11 | |
KEGG: NUDT11 | ||
REACTOME: NUDT11 | ||
Pathway Commons: NUDT11 | ||
Context | iHOP: NUDT11 | |
ligand binding site mutation search in PubMed: NUDT11 | ||
UCL Cancer Institute: NUDT11 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of NUDT11 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for NUDT11 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | 0.27081035 | 1.314252455 | -1.043442105 | 2.13E-13 | 9.86E-13 |
KICH | -2.80054758 | -0.94299958 | -1.857548 | 1.62E-05 | 4.90E-05 |
LUSC | 2.327057047 | -0.431988051 | 2.759045098 | 2.68E-14 | 1.49E-13 |
HNSC | 2.145420978 | 0.526739583 | 1.618681395 | 1.61E-06 | 1.15E-05 |
BLCA | -0.418306317 | 1.285514736 | -1.703821053 | 0.000419 | 0.003490097 |
COAD | -0.784600042 | 0.338507651 | -1.123107692 | 0.000897 | 0.002596205 |
STAD | -1.096452205 | 0.39603842 | -1.492490625 | 0.00011 | 0.00083861 |
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TissGene-miRNA for NUDT11 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NUDT11 |
TissGeneSNV for NUDT11 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.N153K | UCEC | 1 |
p.V82I | STAD | 1 |
p.R19W | PAAD | 1 |
p.S154F | SKCM | 1 |
p.S110L | UCEC | 1 |
p.T10N | OV | 1 |
p.D88Y | SARC | 1 |
p.G60S | UCEC | 1 |
p.R117X | COAD | 1 |
p.D161E | LIHC | 1 |
p.R89H | LGG | 1 |
p.T8M | KIRP | 1 |
p.R89G | BLCA | 1 |
p.Y96H | READ | 1 |
p.M52I | COAD | 1 |
p.D43G | BLCA | 1 |
p.R29S | HNSC | 1 |
p.R40W | STAD | 1 |
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TissGeneCNV for NUDT11 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NUDT11 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for NUDT11 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NUDT11 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NUDT11 |
TissGeneDrug for NUDT11 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NUDT11 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0085859 | Polyglandular Type I Autoimmune Syndrome | 9 | BeFree |
umls:C0004364 | Autoimmune Diseases | 6 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 4 | GAD |
umls:C3494489 | Autoimmune polyendocrinopathy syndrome, type 1 | 4 | BeFree |
umls:C0020626 | Hypoparathyroidism | 3 | BeFree |
umls:C0085409 | Polyendocrinopathies, Autoimmune | 3 | BeFree |
umls:C0006840 | Candidiasis | 2 | BeFree |
umls:C0006845 | Candidiasis, Chronic Mucocutaneous | 2 | BeFree |
umls:C0006848 | Mucocutaneous candidiasis | 2 | BeFree |
umls:C0085215 | Ovarian Failure, Premature | 2 | BeFree |
umls:C0085860 | Autoimmune Syndrome Type II, Polyglandular | 2 | BeFree |
umls:C0596131 | audiogenic seizure | 2 | BeFree |
umls:C0857069 | Chronic candidiasis | 2 | BeFree |
umls:C0014130 | Endocrine System Diseases | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | GAD |
umls:C0040100 | Thymoma | 1 | BeFree |
umls:C0041408 | Turner Syndrome | 1 | BeFree |
umls:C0333463 | Senile Plaques | 1 | BeFree |
umls:C0687720 | Central Diabetes Insipidus | 1 | BeFree |