TissGeneSummary for C14orf105 |
Gene summary |
Basic gene information | Gene symbol | C14orf105 |
Gene name | chromosome 14 open reading frame 105 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 14q22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001283056.1, NM_001283057.1,NM_001283058.1,NM_001283059.1,NM_001283060.1, NM_018168.3, | |
Description | uncharacterized protein C14orf105 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000100557 | ||
HPRD : 12628 | ||
Vega : OTTHUMG00000140317 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C14orf105 | |
BioGPS: 55195 | ||
Pathway | NCI Pathway Interaction Database: C14orf105 | |
KEGG: C14orf105 | ||
REACTOME: C14orf105 | ||
Pathway Commons: C14orf105 | ||
Context | iHOP: C14orf105 | |
ligand binding site mutation search in PubMed: C14orf105 | ||
UCL Cancer Institute: C14orf105 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of C14orf105 | ||
Description by TissGene annotations | Protective TissGene in OS Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C14orf105 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | 5.060230335 | 7.580934335 | -2.520704 | 2.96E-05 | 8.60E-05 |
LIHC | 3.769676335 | 5.291916335 | -1.52224 | 1.57E-05 | 6.36E-05 |
LUAD | -1.559687045 | -2.9393267 | 1.379639655 | 4.83E-06 | 1.47E-05 |
STAD | -0.47893629 | -2.243576915 | 1.764640625 | 0.000884 | 0.004837265 |
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TissGene-miRNA for C14orf105 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C14orf105 |
TissGeneSNV for C14orf105 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R276G | STAD | 1 |
p.L256I | SARC | 1 |
p.Q230K | HNSC | 1 |
p.L206P | BRCA | 1 |
p.A190T | SARC | 1 |
p.G59W | STAD | 1 |
p.P110S | STAD | 1 |
p.E212K | SKCM | 1 |
p.R122* | GBM | 1 |
p.E284Q | BLCA | 1 |
p.K239N | KIRP | 1 |
p.P26S | SKCM | 1 |
p.G29C | LUAD | 1 |
p.S46X | ESCA | 1 |
p.D78Y | READ | 1 |
p.Q253* | HNSC | 1 |
p.W238* | SKCM | 1 |
p.S46* | ESCA | 1 |
p.K279N | KIRP | 1 |
p.R100I | READ | 1 |
p.H175Y | SKCM | 1 |
p.M1I | STAD | 1 |
p.S44P | SKCM | 1 |
p.D78N | LUAD | 1 |
p.D52N | UCEC | 1 |
p.Q53R | LIHC | 1 |
p.S173G | COAD | 1 |
p.G116E | SKCM | 1 |
p.M153T | LUSC | 1 |
p.E135Q | BLCA | 1 |
p.K21R | PRAD | 1 |
p.S27L | BLCA | 1 |
p.W68* | SKCM | 1 |
p.S184C | LGG | 1 |
p.D82H | ESCA | 1 |
p.H248Y | SKCM | 1 |
p.H9Y | HNSC | 1 |
p.Y72H | LGG | 1 |
p.D211N | BLCA | 1 |
p.Q183P | LGG | 1 |
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TissGeneCNV for C14orf105 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C14orf105 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for C14orf105 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C14orf105 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C14orf105 |
TissGeneDrug for C14orf105 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C14orf105 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |