TissGeneSummary for DPPA4 |
Gene summary |
Basic gene information | Gene symbol | DPPA4 |
Gene name | developmental pluripotency associated 4 | |
Synonyms | 2410091M23Rik | |
Cytomap | UCSC genome browser: 3q13.13 | |
Type of gene | protein-coding | |
RefGenes | NM_018189.3, | |
Description | developmental pluripotency-associated protein 4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 614125 | |
HGNC : HGNC | ||
Ensembl : ENSG00000121570 | ||
HPRD : 16836 | ||
Vega : OTTHUMG00000159222 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DPPA4 | |
BioGPS: 55211 | ||
Pathway | NCI Pathway Interaction Database: DPPA4 | |
KEGG: DPPA4 | ||
REACTOME: DPPA4 | ||
Pathway Commons: DPPA4 | ||
Context | iHOP: DPPA4 | |
ligand binding site mutation search in PubMed: DPPA4 | ||
UCL Cancer Institute: DPPA4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLTGCT | |
Reference showing the relevant tissue of DPPA4 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DPPA4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -1.903661263 | 0.220268737 | -2.12393 | 5.22E-12 | 8.92E-11 |
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TissGene-miRNA for DPPA4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DPPA4 |
TissGeneSNV for DPPA4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E155K | SKCM | 3 |
p.P277S | SKCM | 3 |
p.E23D | UCEC | 2 |
p.E27K | SKCM | 2 |
p.P222L | LUAD | 1 |
p.C62F | LUAD | 1 |
p.T191P | HNSC | 1 |
p.P288S | SKCM | 1 |
p.P278H | LUSC | 1 |
p.L271F | MESO | 1 |
p.E304D | GBM | 1 |
p.Y118C | STAD | 1 |
p.A125S | HNSC | 1 |
p.K114T | UCEC | 1 |
p.V257F | LUSC | 1 |
p.A6G | CESC | 1 |
p.S45* | LUSC | 1 |
p.A14V | COAD | 1 |
p.Y118C | UCEC | 1 |
p.E167K | SKCM | 1 |
p.P258S | SKCM | 1 |
p.L99M | LUSC | 1 |
p.E152Q | LUSC | 1 |
p.S31L | BRCA | 1 |
p.T156P | LIHC | 1 |
p.P177H | HNSC | 1 |
p.L185I | LUSC | 1 |
p.K260* | HNSC | 1 |
p.V219L | LUSC | 1 |
p.S5Y | BLCA | 1 |
p.K143* | SKCM | 1 |
p.E138* | UCEC | 1 |
p.S25* | LUSC | 1 |
p.I94S | STAD | 1 |
p.D97N | SKCM | 1 |
p.A211G | LGG | 1 |
p.S300R | STAD | 1 |
p.R3* | UCEC | 1 |
p.E187* | HNSC | 1 |
p.P277L | SKCM | 1 |
p.L238F | SARC | 1 |
p.S144* | LUSC | 1 |
p.R142Q | ESCA | 1 |
p.S21Y | LIHC | 1 |
p.E304K | SKCM | 1 |
p.K77M | LUAD | 1 |
p.A207V | READ | 1 |
p.A213V | COAD | 1 |
p.E304K | GBM | 1 |
p.R120C | STAD | 1 |
p.K137Q | HNSC | 1 |
p.G244C | COAD | 1 |
p.R120S | HNSC | 1 |
p.A6T | BLCA | 1 |
p.E200D | STAD | 1 |
p.N92D | STAD | 1 |
p.H247Y | SKCM | 1 |
p.P277Q | BLCA | 1 |
p.K143X | SKCM | 1 |
p.I141V | STAD | 1 |
p.W102L | STAD | 1 |
p.K130R | ESCA | 1 |
p.P133T | THYM | 1 |
p.V246G | STAD | 1 |
p.V173L | LUSC | 1 |
p.E51K | SKCM | 1 |
p.H164R | COAD | 1 |
p.N294K | LUAD | 1 |
p.W102* | GBM | 1 |
p.A117T | HNSC | 1 |
p.W206* | LUSC | 1 |
p.G244V | HNSC | 1 |
p.A204S | COAD | 1 |
p.S221F | LUSC | 1 |
p.E51K | COAD | 1 |
p.K107R | STAD | 1 |
p.P165S | LUAD | 1 |
p.P83S | SKCM | 1 |
p.P171S | SKCM | 1 |
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TissGeneCNV for DPPA4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DPPA4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BG150443 | ALDH1L2-DPPA4 | chr12:105415637 | chr3:109047067 |
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TissGeneNet for DPPA4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DPPA4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DPPA4 |
TissGeneDrug for DPPA4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DPPA4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036631 | Seminoma | 1 | BeFree |