TissGeneSummary for STK32B |
Gene summary |
Basic gene information | Gene symbol | STK32B |
Gene name | serine/threonine kinase 32B | |
Synonyms | HSA250839|STK32|STKG6|YANK2 | |
Cytomap | UCSC genome browser: 4p16.2 | |
Type of gene | protein-coding | |
RefGenes | NM_018401.1, | |
Description | gene for serine/threonine protein kinaseserine/threonine-protein kinase 32Byet another novel kinase 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000152953 | ||
HPRD : 15446 | ||
Vega : OTTHUMG00000090423 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_STK32B | |
BioGPS: 55351 | ||
Pathway | NCI Pathway Interaction Database: STK32B | |
KEGG: STK32B | ||
REACTOME: STK32B | ||
Pathway Commons: STK32B | ||
Context | iHOP: STK32B | |
ligand binding site mutation search in PubMed: STK32B | ||
UCL Cancer Institute: STK32B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHTGCT | |
Reference showing the relevant tissue of STK32B | ||
Description by TissGene annotations | Protective TissGene in RFS Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for STK32B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BLCA | -3.008716931 | -0.795469562 | -2.213247368 | 4.01E-06 | 9.76E-05 |
THCA | -3.353026654 | -1.903296146 | -1.449730508 | 7.90E-16 | 1.21E-14 |
KICH | -0.359929773 | 2.289114227 | -2.649044 | 3.50E-06 | 1.19E-05 |
COAD | -3.328803773 | -1.654865311 | -1.673938462 | 1.34E-08 | 1.17E-07 |
ESCA | -2.1888265 | -0.153608318 | -2.035218182 | 0.00383 | 0.033667668 |
STAD | -1.841891273 | -0.740535023 | -1.10135625 | 0.00251 | 0.010961146 |
KIRP | 1.183268102 | 2.500336852 | -1.31706875 | 0.0013 | 0.003473897 |
LIHC | -3.711383773 | -4.722275773 | 1.010892 | 6.14E-05 | 0.0002221 |
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TissGene-miRNA for STK32B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
THYM | hsa-miR-27a-3p | MIMAT0000084 | 0.0033 | -0.26 | 122 |
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TissGeneMut for STK32B |
TissGeneSNV for STK32B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.F292L | BLCA | 2 |
p.R270C | STAD | 2 |
p.R386Q | CESC | 1 |
p.A257G | CESC | 1 |
p.H326R | ESCA | 1 |
p.E94* | LUAD | 1 |
p.P346Q | LIHC | 1 |
p.K47T | READ | 1 |
p.A257P | COAD | 1 |
p.T169M | BLCA | 1 |
p.Q57H | UCEC | 1 |
p.R27W | UCEC | 1 |
p.G32V | LUSC | 1 |
p.R27Q | BLCA | 1 |
p.L153P | LIHC | 1 |
p.G35R | SKCM | 1 |
p.R198T | LUAD | 1 |
p.R386L | BLCA | 1 |
p.E314K | LUSC | 1 |
p.T169M | UCEC | 1 |
p.I277T | KIRC | 1 |
p.G158R | BRCA | 1 |
p.A284V | THYM | 1 |
p.M48L | COAD | 1 |
p.K31R | BLCA | 1 |
p.I127S | LIHC | 1 |
p.E175K | SKCM | 1 |
p.N19I | LUAD | 1 |
p.D146N | STAD | 1 |
p.H406Y | LIHC | 1 |
p.V100L | LUAD | 1 |
p.L325I | STAD | 1 |
p.R270H | STAD | 1 |
p.H144Y | SKCM | 1 |
p.Y282X | LGG | 1 |
p.Y282* | LGG | 1 |
p.G201R | LUSC | 1 |
p.R220W | PRAD | 1 |
p.G201R | UCEC | 1 |
p.R70W | STAD | 1 |
p.R66Q | UCEC | 1 |
p.V68D | LIHC | 1 |
p.H350R | LGG | 1 |
p.G398R | LIHC | 1 |
p.G201R | SARC | 1 |
p.R70W | HNSC | 1 |
p.E368K | BLCA | 1 |
p.Q114L | BLCA | 1 |
p.P346L | STAD | 1 |
p.F362L | STAD | 1 |
p.E243A | COAD | 1 |
p.R338K | BLCA | 1 |
p.R220W | COAD | 1 |
p.Y247H | STAD | 1 |
p.D146Y | UCEC | 1 |
p.G32R | LUSC | 1 |
p.P200L | HNSC | 1 |
p.L86M | HNSC | 1 |
p.R70L | LUAD | 1 |
p.K334N | UCEC | 1 |
p.E321Q | LUSC | 1 |
p.G106V | ESCA | 1 |
p.G182D | LGG | 1 |
p.A295T | LIHC | 1 |
p.M1I | ESCA | 1 |
p.T169M | COAD | 1 |
p.R336I | UCEC | 1 |
p.K36_splice | LUSC | 1 |
p.E93K | HNSC | 1 |
p.E317* | BLCA | 1 |
p.G158X | LIHC | 1 |
p.V116E | LUAD | 1 |
p.D276G | HNSC | 1 |
p.G388R | THCA | 1 |
p.R220W | UCEC | 1 |
p.R43* | STAD | 1 |
p.G3W | LUAD | 1 |
p.V160F | UCEC | 1 |
p.K342Q | THCA | 1 |
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TissGeneCNV for STK32B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for STK32B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF928354 | STK32B-PLEKHM3 | chr4:5410227 | chr2:208866280 | |
Chimerdb3.0 | FusionScan | SARC | TCGA-FX-A3NK-01A | STK32B-SOBP | Out-of-Frame | chr4:5170177 | chr6:107824860 |
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TissGeneNet for STK32B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for STK32B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for STK32B |
TissGeneDrug for STK32B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for STK32B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002395 | Alzheimer's Disease | 1 | GWASCAT |
umls:C0008924 | Cleft Lip | 1 | GAD |
umls:C0008925 | Cleft Palate | 1 | GAD |
umls:C0010068 | Coronary heart disease | 1 | GWASCAT |
umls:C0013903 | Ellis-Van Creveld Syndrome | 1 | BeFree |
umls:C0026106 | Mild Mental Retardation | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0585362 | Squamous cell carcinoma of mouth | 1 | BeFree |
umls:C0810364 | Cleft Lip with or without Cleft Palate | 1 | BeFree |