TissGeneSummary for PPY |
Gene summary |
Basic gene information | Gene symbol | PPY |
Gene name | pancreatic polypeptide | |
Synonyms | PNP | |
Cytomap | UCSC genome browser: 17q21 | |
Type of gene | protein-coding | |
RefGenes | NM_002722.3, | |
Description | PPpancreatic polypeptide Ypancreatic prohormoneprepro-PP (prepropancreatic polypeptide) | |
Modification date | 20141207 | |
dbXrefs | MIM : 167780 | |
HGNC : HGNC | ||
Ensembl : ENSG00000108849 | ||
HPRD : 01340 | ||
Vega : OTTHUMG00000181800 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PPY | |
BioGPS: 5539 | ||
Pathway | NCI Pathway Interaction Database: PPY | |
KEGG: PPY | ||
REACTOME: PPY | ||
Pathway Commons: PPY | ||
Context | iHOP: PPY | |
ligand binding site mutation search in PubMed: PPY | ||
UCL Cancer Institute: PPY | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
Reference showing the relevant tissue of PPY | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PPY |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -0.280626498 | 1.517849773 | -1.798476271 | 2.03E-07 | 8.50E-07 |
COAD | -0.90146672 | 1.105321742 | -2.006788462 | 4.03E-05 | 0.000160833 |
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TissGene-miRNA for PPY |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PPY |
TissGeneSNV for PPY |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P43S | SKCM | 2 |
p.S14F | SKCM | 1 |
p.C16Y | LUAD | 1 |
p.G26D | STAD | 1 |
p.P37S | SKCM | 1 |
p.R54H | STAD | 1 |
p.T73M | UCEC | 1 |
p.A4T | HNSC | 1 |
p.E44K | HNSC | 1 |
p.G29E | SKCM | 1 |
p.A4T | UCEC | 1 |
p.A27V | LUAD | 1 |
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TissGeneCNV for PPY |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PPY |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BP384232 | TRIM41-PPY | chr5:180662580 | chr17:42018172 | |
Chimerdb3.0 | ChiTaRs | NA | BP384968 | DDX39B-PPY | chr6:2829961 | chr17:42018172 | |
Chimerdb3.0 | ChiTaRs | NA | BP394212 | TEAD2-PPY | chr19:49844436 | chr17:42018173 | |
Chimerdb3.0 | ChiTaRs | NA | BP396278 | PPY-LARP6 | chr17:42018531 | chr15:71123889 | |
Chimerdb3.0 | ChiTaRs | NA | BP386860 | SLCO1A2-PPY | chr12:21532605 | chr17:42018174 | |
Chimerdb3.0 | ChiTaRs | NA | BP386553 | PPY-HBA2 | chr17:42018927 | chr16:223496 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-A7-A3J0-01A | MPP2-PPY | In-frame | Chr17:41975630 | Chr17:42019022 |
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TissGeneNet for PPY |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PPY |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PPY |
TissGeneDrug for PPY |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PPY |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002395 | Alzheimer's Disease | 3 | BeFree |
umls:C0003650 | Apudoma | 2 | BeFree |
umls:C0025267 | Multiple Endocrine Neoplasia Type 1 | 2 | BeFree |
umls:C0028754 | Obesity | 2 | BeFree |
umls:C0206754 | Neuroendocrine Tumors | 2 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
umls:C0600139 | Prostate carcinoma | 2 | BeFree |
umls:C0002793 | Anaplasia | 1 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
umls:C0020437 | Hypercalcemia | 1 | BeFree |
umls:C0020615 | Hypoglycemia | 1 | BeFree |
umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
umls:C0024299 | Lymphoma | 1 | BeFree |
umls:C0025007 | Measles | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0027662 | Multiple Endocrine Neoplasia | 1 | BeFree |
umls:C0028756 | Obesity, Morbid | 1 | BeFree |
umls:C0030305 | Pancreatitis | 1 | LHGDN |
umls:C0030421 | Paraganglioma | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
umls:C0242363 | Islet Cell Tumor | 1 | BeFree |
umls:C0271650 | Impaired glucose tolerance | 1 | BeFree |
umls:C0341862 | Hypothalamic amenorrhea | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0746408 | mass lesion | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | BeFree |
umls:C1270972 | Mild cognitive disorder | 1 | BeFree |
umls:C1337011 | Well Differentiated Pancreatic Endocrine Tumor | 1 | BeFree |