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| TissGeneSummary for SAGE1 |
 Gene summary |
| Basic gene information | Gene symbol | SAGE1 |
| Gene name | sarcoma antigen 1 | |
| Synonyms | CT14|SAGE | |
| Cytomap | UCSC genome browser: Xq26 | |
| Type of gene | protein-coding | |
| RefGenes | NM_018666.2, | |
| Description | cancer/testis antigen 14putative tumor antigen | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300359 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000181433 | ||
| HPRD : 02290 | ||
| Vega : OTTHUMG00000022496 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SAGE1 | |
| BioGPS: 55511 | ||
| Pathway | NCI Pathway Interaction Database: SAGE1 | |
| KEGG: SAGE1 | ||
| REACTOME: SAGE1 | ||
| Pathway Commons: SAGE1 | ||
| Context | iHOP: SAGE1 | |
| ligand binding site mutation search in PubMed: SAGE1 | ||
| UCL Cancer Institute: SAGE1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of SAGE1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SAGE1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | -0.341051457 | -1.480873332 | 1.139821875 | 0.00958 | 0.033352043 |
| LUSC | -0.183936873 | -1.33202903 | 1.148092157 | 0.00376 | 0.006439179 |
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| TissGene-miRNA for SAGE1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SAGE1 |
| TissGeneSNV for SAGE1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R451Q | SKCM | 2 |
| p.E727K | SKCM | 2 |
| p.R123Q | SKCM | 2 |
| p.A785G | LUAD | 1 |
| p.Q686K | BLCA | 1 |
| p.R860I | CESC | 1 |
| p.P189H | UCEC | 1 |
| p.A593S | ACC | 1 |
| p.V863F | LUAD | 1 |
| p.V876G | COAD | 1 |
| p.A109G | ESCA | 1 |
| p.E883Q | ESCA | 1 |
| p.G469E | SKCM | 1 |
| p.P310L | STAD | 1 |
| p.R226X | SKCM | 1 |
| p.H152_splice | LUSC | 1 |
| p.R229C | COAD | 1 |
| p.S661L | SKCM | 1 |
| p.K903N | READ | 1 |
| p.V437I | SARC | 1 |
| p.R630C | LGG | 1 |
| p.A482T | SKCM | 1 |
| p.S771I | LUAD | 1 |
| p.T663K | UCEC | 1 |
| p.T571I | UCEC | 1 |
| p.S762F | SKCM | 1 |
| p.G704E | SKCM | 1 |
| p.E864K | SKCM | 1 |
| p.I889M | BRCA | 1 |
| p.S57C | LIHC | 1 |
| p.R653H | OV | 1 |
| p.S129* | LUSC | 1 |
| p.W68* | LUAD | 1 |
| p.N683T | STAD | 1 |
| p.I277T | COAD | 1 |
| p.L561F | LUAD | 1 |
| p.A885V | LGG | 1 |
| p.R51* | LUAD | 1 |
| p.R478G | LUSC | 1 |
| p.S816F | READ | 1 |
| p.D266N | LAML | 1 |
| p.D797Y | LUAD | 1 |
| p.M305T | LUAD | 1 |
| p.R836X | STAD | 1 |
| p.C709S | GBM | 1 |
| p.P263L | SKCM | 1 |
| p.E447* | LUAD | 1 |
| p.R489H | LGG | 1 |
| p.M240I | BLCA | 1 |
| p.M258I | SKCM | 1 |
| p.I879F | BRCA | 1 |
| p.E541K | SKCM | 1 |
| p.E83V | LIHC | 1 |
| p.S693P | READ | 1 |
| p.R226L | UCEC | 1 |
| p.M755I | ACC | 1 |
| p.M569T | UCS | 1 |
| p.G281R | SKCM | 1 |
| p.R844T | BLCA | 1 |
| p.Q134P | LUAD | 1 |
| p.D620N | SKCM | 1 |
| p.I484M | LUAD | 1 |
| p.R836X | COAD | 1 |
| p.T124I | KICH | 1 |
| p.K54N | UCEC | 1 |
| p.R489C | COAD | 1 |
| p.W68C | LUAD | 1 |
| p.D825N | LUSC | 1 |
| p.N158Y | LIHC | 1 |
| p.S693P | STAD | 1 |
| p.N267T | STAD | 1 |
| p.H345Q | LIHC | 1 |
| p.S129L | BRCA | 1 |
| p.P406S | LUAD | 1 |
| p.E303K | LUAD | 1 |
| p.N466Y | LUAD | 1 |
| p.E746D | STAD | 1 |
| p.T203I | STAD | 1 |
| p.I323T | LUAD | 1 |
| p.S58L | SKCM | 1 |
| p.E114K | BLCA | 1 |
| p.A131T | STAD | 1 |
| p.E851Q | HNSC | 1 |
| p.D385N | SKCM | 1 |
| p.D714N | SKCM | 1 |
| p.P734H | ESCA | 1 |
| p.G181W | STAD | 1 |
| p.A672T | UCEC | 1 |
| p.R113C | UCEC | 1 |
| p.V315G | GBM | 1 |
| p.G120D | LIHC | 1 |
| p.G283D | STAD | 1 |
| p.S67L | STAD | 1 |
| p.A785V | PAAD | 1 |
| p.T248P | LUAD | 1 |
| p.N401S | UCEC | 1 |
| p.R160H | PRAD | 1 |
| p.M146T | LUAD | 1 |
| p.N252I | KIRC | 1 |
| p.A362T | UCEC | 1 |
| p.P332L | STAD | 1 |
| p.R844I | UCEC | 1 |
| p.A482D | SKCM | 1 |
| p.S270L | CESC | 1 |
| p.K821N | UCEC | 1 |
| p.P426R | LUAD | 1 |
| p.D507N | SKCM | 1 |
| p.P263T | LUSC | 1 |
| p.R226* | SKCM | 1 |
| p.E584K | SKCM | 1 |
| p.H583Y | SKCM | 1 |
| p.A192S | BRCA | 1 |
| p.S708L | SKCM | 1 |
| p.E727* | LUAD | 1 |
| p.R619K | ESCA | 1 |
| p.L135R | COAD | 1 |
| p.H137N | BLCA | 1 |
| p.H627Y | SKCM | 1 |
| p.D526N | BRCA | 1 |
| p.D501N | SKCM | 1 |
| p.K821T | UCEC | 1 |
| p.G275W | UCEC | 1 |
| p.D407N | SKCM | 1 |
| p.A717D | LUSC | 1 |
| p.I465M | BRCA | 1 |
| p.A412V | SKCM | 1 |
| p.I566T | CESC | 1 |
| p.R228Q | SKCM | 1 |
| p.V174G | UCEC | 1 |
| p.G261D | COAD | 1 |
| p.E864K | BRCA | 1 |
| p.E864* | LUAD | 1 |
| p.R51G | STAD | 1 |
| p.T673S | OV | 1 |
| p.A40S | THYM | 1 |
| p.N205S | UCEC | 1 |
| p.L222S | READ | 1 |
| p.R489C | UCEC | 1 |
| p.V214A | BRCA | 1 |
| p.Y829F | LIHC | 1 |
| p.M446I | BLCA | 1 |
| p.T224S | LIHC | 1 |
| p.R116S | BLCA | 1 |
| p.D377N | SKCM | 1 |
| p.D825Y | LUAD | 1 |
| p.P509T | STAD | 1 |
| p.S740* | HNSC | 1 |
| p.E397V | LIHC | 1 |
| p.E746D | TGCT | 1 |
| p.H627Y | BRCA | 1 |
| p.M540I | LUAD | 1 |
| p.R896I | UCEC | 1 |
| p.L878I | SKCM | 1 |
| p.A609S | UCEC | 1 |
| p.P603S | SKCM | 1 |
| p.P734L | LUAD | 1 |
| p.R836* | STAD | 1 |
| p.P144L | SKCM | 1 |
| p.V531I | UCEC | 1 |
| p.T751A | STAD | 1 |
| p.P104S | SKCM | 1 |
| p.D479N | SKCM | 1 |
| p.F862C | UCEC | 1 |
| p.A468E | COAD | 1 |
| p.D780E | LGG | 1 |
| p.N790T | LIHC | 1 |
| p.S662F | SKCM | 1 |
| p.R630H | READ | 1 |
| p.V437I | STAD | 1 |
| p.P101S | CHOL | 1 |
| p.F846L | CESC | 1 |
| p.A624E | LUAD | 1 |
| p.G42E | STAD | 1 |
| p.K63N | BLCA | 1 |
| p.P426T | LUAD | 1 |
| p.D595N | UCEC | 1 |
| p.M146I | BLCA | 1 |
| p.H580N | STAD | 1 |
| p.T203P | PRAD | 1 |
| p.G422E | SKCM | 1 |
| p.R228Q | LUAD | 1 |
| p.E256K | SKCM | 1 |
| p.E259K | SKCM | 1 |
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| TissGeneCNV for SAGE1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SAGE1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-VR-AA7B-01A | SF1-SAGE1 | In-Frame | chr11:64543969 | chrX:134988182 |
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| TissGeneNet for SAGE1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SAGE1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SAGE1 |
| TissGeneDrug for SAGE1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SAGE1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0678222 | Breast Carcinoma | 5 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
| umls:C0017636 | Glioblastoma | 3 | BeFree |
| umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 2 | BeFree |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0024121 | Lung Neoplasms | 2 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
| umls:C0025202 | melanoma | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | BeFree |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
| umls:C0002894 | Refractory anaemia with excess blasts | 1 | BeFree |
| umls:C0004096 | Asthma | 1 | BeFree |
| umls:C0007113 | Rectal Carcinoma | 1 | BeFree |
| umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0007766 | Intracranial Aneurysm | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
| umls:C0025149 | Medulloblastoma | 1 | BeFree |
| umls:C0028043 | Nicotine Dependence | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0030567 | Parkinson Disease | 1 | BeFree |
| umls:C0035309 | Retinal Diseases | 1 | BeFree |
| umls:C0036631 | Seminoma | 1 | BeFree |
| umls:C0037274 | Dermatologic disorders | 1 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0334517 | Spermatocytic seminoma | 1 | BeFree |
| umls:C0334583 | Pilocytic Astrocytoma | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0936223 | Metastatic Prostate Carcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
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