TissGeneSummary for C1orf112 |
Gene summary |
Basic gene information | Gene symbol | C1orf112 |
Gene name | chromosome 1 open reading frame 112 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 1q24.2 | |
Type of gene | protein-coding | |
RefGenes | NM_018186.2, | |
Description | uncharacterized protein C1orf112 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
HPRD : 07694 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C1orf112 | |
BioGPS: 55732 | ||
Pathway | NCI Pathway Interaction Database: C1orf112 | |
KEGG: C1orf112 | ||
REACTOME: C1orf112 | ||
Pathway Commons: C1orf112 | ||
Context | iHOP: C1orf112 | |
ligand binding site mutation search in PubMed: C1orf112 | ||
UCL Cancer Institute: C1orf112 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
Reference showing the relevant tissue of C1orf112 | ||
Description by TissGene annotations | Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C1orf112 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | 0.315265738 | -0.957543637 | 1.272809375 | 8.30E-10 | 7.18E-08 |
COAD | 0.732153959 | -0.372757579 | 1.104911538 | 4.55E-11 | 7.17E-10 |
LUAD | 0.449825975 | -1.283067128 | 1.732893103 | 9.79E-27 | 5.61E-25 |
LUSC | 1.232230505 | -0.982963612 | 2.215194118 | 1.21E-28 | 4.26E-27 |
BRCA | 1.134072043 | -0.083615676 | 1.217687719 | 2.11E-36 | 4.21E-35 |
HNSC | 0.821173369 | -0.351612678 | 1.172786047 | 3.18E-14 | 1.75E-12 |
BLCA | 1.364850113 | -0.393976203 | 1.758826316 | 1.71E-08 | 1.52E-06 |
ESCA | 0.840695568 | -0.66888625 | 1.509581818 | 2.75E-05 | 0.001388764 |
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TissGene-miRNA for C1orf112 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C1orf112 |
TissGeneSNV for C1orf112 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.H8N | BRCA | 1 |
p.D28N | STAD | 1 |
p.W830* | KIRC | 1 |
p.E797K | UCS | 1 |
p.S90F | SKCM | 1 |
p.D29N | CESC | 1 |
p.Y110F | LIHC | 1 |
p.D149H | KIRC | 1 |
p.S108Y | LUAD | 1 |
p.E772G | HNSC | 1 |
p.D671E | BLCA | 1 |
p.F384L | LUAD | 1 |
p.V327F | UCEC | 1 |
p.A128D | HNSC | 1 |
p.E726D | LIHC | 1 |
p.E393* | SKCM | 1 |
p.M324I | ESCA | 1 |
p.L147X | READ | 1 |
p.Q189H | HNSC | 1 |
p.T99R | HNSC | 1 |
p.L215I | LGG | 1 |
p.I499V | LUSC | 1 |
p.S163Y | UCEC | 1 |
p.F798L | DLBC | 1 |
p.S405N | LUAD | 1 |
p.A412V | UCEC | 1 |
p.Q194R | UCS | 1 |
p.A837V | UCEC | 1 |
p.D205Y | READ | 1 |
p.A698V | UCEC | 1 |
p.L215I | UCEC | 1 |
p.S806P | UCEC | 1 |
p.K381T | COAD | 1 |
p.L279F | BLCA | 1 |
p.Q77X | STAD | 1 |
p.R847C | UCEC | 1 |
p.Q598X | THCA | 1 |
p.L713F | UCEC | 1 |
p.A481S | COAD | 1 |
p.K658E | LUAD | 1 |
p.A474V | THYM | 1 |
p.P682L | STAD | 1 |
p.S163C | BLCA | 1 |
p.S308L | CESC | 1 |
p.W830X | KIRC | 1 |
p.E542Q | CESC | 1 |
p.E603K | OV | 1 |
p.L400S | UCEC | 1 |
p.V729F | UCEC | 1 |
p.A303S | THYM | 1 |
p.V349F | ESCA | 1 |
p.S255F | SKCM | 1 |
p.M157I | BLCA | 1 |
p.Q280H | CESC | 1 |
p.F340C | COAD | 1 |
p.F285S | DLBC | 1 |
p.G813R | SKCM | 1 |
p.L497I | UCEC | 1 |
p.Q598* | THCA | 1 |
p.S355Y | HNSC | 1 |
p.D175Y | THYM | 1 |
p.Y467D | UCEC | 1 |
p.S674A | LUAD | 1 |
p.L528M | LGG | 1 |
p.S655L | LUAD | 1 |
p.V585E | KIRC | 1 |
p.E573D | UCEC | 1 |
p.F185L | KIRP | 1 |
p.Q624* | LUAD | 1 |
p.L612* | BLCA | 1 |
p.H5Y | CESC | 1 |
p.F252L | STAD | 1 |
p.L497I | CHOL | 1 |
p.T51A | STAD | 1 |
p.S190N | UCEC | 1 |
p.L483_splice | UCEC | 1 |
p.V383I | UCEC | 1 |
p.Q77* | STAD | 1 |
p.S308* | HNSC | 1 |
p.S521P | LIHC | 1 |
p.V578I | GBM | 1 |
p.T366I | HNSC | 1 |
p.G489R | SKCM | 1 |
p.E437K | BRCA | 1 |
p.K247R | COAD | 1 |
p.I55F | BRCA | 1 |
p.S498L | UCEC | 1 |
p.R503H | UCEC | 1 |
p.T182I | UCEC | 1 |
p.S395C | CESC | 1 |
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TissGeneCNV for C1orf112 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C1orf112 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI077524 | C1orf112-HSP90AA1 | chr1:169822631 | chr14:102549604 | |
Chimerdb3.0 | ChiTaRs | NA | BQ067630 | NBPF14-C1orf112 | chr1:144836806 | chr1:169722345 | |
Chimerdb3.0 | ChiTaRs | NA | AI140909 | C1orf112-NEGR1 | chr1:169818828 | chr1:72666225 | |
Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A1KU-01A | UCHL5-C1orf112 | In-Frame | chr1:192990226 | chr1:169818640 |
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TissGeneNet for C1orf112 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C1orf112 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C1orf112 |
TissGeneDrug for C1orf112 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C1orf112 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020538 | Hypertensive disease | 1 | GAD |
umls:C0029456 | Osteoporosis | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |