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| TissGeneSummary for ST6GALNAC1 |
 Gene summary |
| Basic gene information | Gene symbol | ST6GALNAC1 |
| Gene name | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | |
| Synonyms | HSY11339|SIAT7A|ST6GalNAcI|STYI | |
| Cytomap | UCSC genome browser: 17q25.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001289107.1, NM_018414.4,NR_110309.1, | |
| Description | GalNAc alpha-2, 6-sialyltransferase I, long formSIAT7-AST6GalNAc Ialpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1galNAc alpha-2,6-sialyltransferase Isialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactos | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 610138 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000070526 | ||
| HPRD : 15340 | ||
| Vega : OTTHUMG00000180369 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ST6GALNAC1 | |
| BioGPS: 55808 | ||
| Pathway | NCI Pathway Interaction Database: ST6GALNAC1 | |
| KEGG: ST6GALNAC1 | ||
| REACTOME: ST6GALNAC1 | ||
| Pathway Commons: ST6GALNAC1 | ||
| Context | iHOP: ST6GALNAC1 | |
| ligand binding site mutation search in PubMed: ST6GALNAC1 | ||
| UCL Cancer Institute: ST6GALNAC1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixColon | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCCOAD | |
| Reference showing the relevant tissue of ST6GALNAC1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ST6GALNAC1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -1.275596702 | 0.933321719 | -2.208918421 | 1.10E-21 | 8.89E-21 |
| KICH | -3.813886035 | -2.135970035 | -1.677916 | 6.95E-07 | 2.67E-06 |
| HNSC | 2.109202523 | 4.788100197 | -2.678897674 | 9.29E-10 | 1.53E-08 |
| COAD | 6.333408426 | 7.745058426 | -1.41165 | 0.000316 | 0.001024195 |
| LIHC | -3.047988035 | -1.642384035 | -1.405604 | 3.23E-05 | 0.00012305 |
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| TissGene-miRNA for ST6GALNAC1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ST6GALNAC1 |
| TissGeneSNV for ST6GALNAC1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E266K | SKCM | 1 |
| p.A119T | STAD | 1 |
| p.W576* | CESC | 1 |
| p.S177Y | LUAD | 1 |
| p.R497Q | SKCM | 1 |
| p.L579I | SARC | 1 |
| p.E78K | HNSC | 1 |
| p.Q106H | LIHC | 1 |
| p.E401K | UCEC | 1 |
| p.A415V | LGG | 1 |
| p.R250K | BLCA | 1 |
| p.T163M | OV | 1 |
| p.S409F | SKCM | 1 |
| p.M459I | COAD | 1 |
| p.R518C | MESO | 1 |
| p.S307Y | LUAD | 1 |
| p.D581N | PRAD | 1 |
| p.Q294* | SKCM | 1 |
| p.A512T | UCEC | 1 |
| p.R247K | BLCA | 1 |
| p.S354N | TGCT | 1 |
| p.S506Y | UCEC | 1 |
| p.R440L | THYM | 1 |
| p.L301H | COAD | 1 |
| p.L59M | COAD | 1 |
| p.M464L | STAD | 1 |
| p.N135D | KIRC | 1 |
| p.Q112K | LUSC | 1 |
| p.G168V | LIHC | 1 |
| p.R440C | LUSC | 1 |
| p.S506F | BLCA | 1 |
| p.E319Q | BRCA | 1 |
| p.I424V | COAD | 1 |
| p.R497X | THYM | 1 |
| p.P197S | SKCM | 1 |
| p.K284T | SKCM | 1 |
| p.W558R | UCEC | 1 |
| p.D555E | LUAD | 1 |
| p.E446K | SKCM | 1 |
| p.T175M | STAD | 1 |
| p.S290L | SKCM | 1 |
| p.E111K | LUAD | 1 |
| p.T96I | LGG | 1 |
| p.Q312H | BRCA | 1 |
| p.R497Q | CESC | 1 |
| p.G545C | LUAD | 1 |
| p.S12R | BLCA | 1 |
| p.E53V | ESCA | 1 |
| p.P243S | LUAD | 1 |
| p.L423F | SARC | 1 |
| p.L291P | LUSC | 1 |
| p.G169D | LIHC | 1 |
| p.A357T | BRCA | 1 |
| p.S409F | LUAD | 1 |
| p.Q232* | BLCA | 1 |
| p.G218E | SKCM | 1 |
| p.D581N | SKCM | 1 |
| p.I585T | PCPG | 1 |
| p.R47S | ACC | 1 |
| p.R150W | LUAD | 1 |
| p.G405W | PRAD | 1 |
| p.P225S | SKCM | 1 |
| p.Q294X | SKCM | 1 |
| Top |
| TissGeneCNV for ST6GALNAC1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ST6GALNAC1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BQ326548 | ST6GALNAC1-NDE1 | chr17:74625372 | chr16:15797759 | |
| Chimerdb3.0 | ChiTaRs | NA | CV336378 | ST6GALNAC1-ST6GALNAC1 | chr17:74636387 | chr17:74636419 |
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| TissGeneNet for ST6GALNAC1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ST6GALNAC1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ST6GALNAC1 |
| TissGeneDrug for ST6GALNAC1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ST6GALNAC1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0005586 | Bipolar Disorder | 1 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree |
| umls:C0033975 | Psychotic Disorders | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0349204 | Nonorganic psychosis | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
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