TissGeneSummary for ADCY10 |
Gene summary |
Basic gene information | Gene symbol | ADCY10 |
Gene name | adenylate cyclase 10 (soluble) | |
Synonyms | HCA2|SAC|SACI|Sacy|hsAC | |
Cytomap | UCSC genome browser: 1q24 | |
Type of gene | protein-coding | |
RefGenes | NM_001167749.2, NM_001297772.1,NM_018417.5, | |
Description | 3',5'-cyclic AMP synthetaseAH-related proteinATP pyrophosphate-lyaseadenylate cyclase type 10germ cell soluble adenylyl cyclasetesticular soluble adenylyl cyclase (SAC) | |
Modification date | 20141222 | |
dbXrefs | MIM : 605205 | |
HGNC : HGNC | ||
Ensembl : ENSG00000143199 | ||
HPRD : 05549 | ||
Vega : OTTHUMG00000034573 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADCY10 | |
BioGPS: 55811 | ||
Pathway | NCI Pathway Interaction Database: ADCY10 | |
KEGG: ADCY10 | ||
REACTOME: ADCY10 | ||
Pathway Commons: ADCY10 | ||
Context | iHOP: ADCY10 | |
ligand binding site mutation search in PubMed: ADCY10 | ||
UCL Cancer Institute: ADCY10 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ADCY10 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ADCY10 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 1.096272344 | -0.57486295 | 1.671135294 | 4.21E-06 | 9.96E-06 |
HNSC | 0.667363497 | -0.750459758 | 1.417823256 | 1.25E-05 | 6.93E-05 |
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TissGene-miRNA for ADCY10 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ADCY10 |
TissGeneSNV for ADCY10 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P882S | SKCM | 2 |
p.P821S | SKCM | 2 |
p.E823K | SKCM | 2 |
p.E1315K | SKCM | 2 |
p.E1254K | SKCM | 2 |
p.S1351F | SKCM | 2 |
p.P1074S | SKCM | 2 |
p.V1436I | SKCM | 1 |
p.E216K | HNSC | 1 |
p.I471T | SKCM | 1 |
p.A313T | OV | 1 |
p.A533S | STAD | 1 |
p.P221H | LUAD | 1 |
p.G698D | LIHC | 1 |
p.I639N | UCEC | 1 |
p.I544V | COAD | 1 |
p.Q162X | SKCM | 1 |
p.A97V | THYM | 1 |
p.D568A | BRCA | 1 |
p.A160V | SKCM | 1 |
p.M1T | STAD | 1 |
p.D483N | LUSC | 1 |
p.P809L | STAD | 1 |
p.Q661H | LUAD | 1 |
p.E653K | SKCM | 1 |
p.K1136R | LUAD | 1 |
p.R50* | PAAD | 1 |
p.A450V | LGG | 1 |
p.V1266G | SKCM | 1 |
p.R1163Q | PAAD | 1 |
p.L1449V | LUAD | 1 |
p.E266K | BLCA | 1 |
p.L1291F | ESCA | 1 |
p.L986F | THCA | 1 |
p.A97V | LUSC | 1 |
p.M1144I | BLCA | 1 |
p.L1132V | BLCA | 1 |
p.E1305Q | CESC | 1 |
p.F226V | UCEC | 1 |
p.E309Q | BLCA | 1 |
p.V1493I | BLCA | 1 |
p.R835Q | SKCM | 1 |
p.V83M | SKCM | 1 |
p.S1388F | SKCM | 1 |
p.A286V | COAD | 1 |
p.G877S | BLCA | 1 |
p.S1350C | LUAD | 1 |
p.L787F | SKCM | 1 |
p.E1338K | SKCM | 1 |
p.P241H | UCEC | 1 |
p.R872C | SKCM | 1 |
p.E444* | UCEC | 1 |
p.W1428X | SKCM | 1 |
p.L1347I | THYM | 1 |
p.Q87H | HNSC | 1 |
p.E876K | SKCM | 1 |
p.M1147I | SKCM | 1 |
p.E1211X | SKCM | 1 |
p.L1357I | BLCA | 1 |
p.P758L | SKCM | 1 |
p.Q1592E | CESC | 1 |
p.S672F | SKCM | 1 |
p.S733F | BLCA | 1 |
p.T464I | BLCA | 1 |
p.L596I | UCEC | 1 |
p.S723Y | LUAD | 1 |
p.R489C | UCEC | 1 |
p.I1282N | PAAD | 1 |
p.E1399K | SKCM | 1 |
p.R109Q | BLCA | 1 |
p.L632M | KIRP | 1 |
p.A985T | SKCM | 1 |
p.E912K | SKCM | 1 |
p.F96C | UCEC | 1 |
p.M1187I | SKCM | 1 |
p.R833M | LUAD | 1 |
p.H801Q | LUAD | 1 |
p.C618F | LUAD | 1 |
p.H1134Y | SKCM | 1 |
p.T486I | LUAD | 1 |
p.H1515N | ESCA | 1 |
p.S456Y | UCEC | 1 |
p.V376F | STAD | 1 |
p.D497H | LUAD | 1 |
p.Q1405* | BRCA | 1 |
p.K1200N | LUAD | 1 |
p.Q118* | LUAD | 1 |
p.L861P | UCEC | 1 |
p.R142X | LGG | 1 |
p.E1429K | SKCM | 1 |
p.E937K | SKCM | 1 |
p.A1511D | SARC | 1 |
p.R822C | SKCM | 1 |
p.H459Y | LUAD | 1 |
p.E1549D | UCEC | 1 |
p.E939K | UCEC | 1 |
p.K501N | UCEC | 1 |
p.G457V | STAD | 1 |
p.S561F | SKCM | 1 |
p.S698R | SKCM | 1 |
p.E217Q | BLCA | 1 |
p.W1468C | LUAD | 1 |
p.E1245K | SKCM | 1 |
p.A683V | UCEC | 1 |
p.R142Q | STAD | 1 |
p.G297R | LIHC | 1 |
p.L664V | CESC | 1 |
p.H509N | LGG | 1 |
p.I1492S | LGG | 1 |
p.P962S | SKCM | 1 |
p.A1254T | PCPG | 1 |
p.P758S | LUAD | 1 |
p.L726F | SKCM | 1 |
p.W1581C | CHOL | 1 |
p.S733F | SKCM | 1 |
p.A474T | UCEC | 1 |
p.K1228R | LUAD | 1 |
p.A1094T | UCEC | 1 |
p.W1489* | SKCM | 1 |
p.D483N | UCS | 1 |
p.K1108N | LUAD | 1 |
p.E1272* | SKCM | 1 |
p.V1205G | SKCM | 1 |
p.T578I | LUAD | 1 |
p.D1292G | SKCM | 1 |
p.E792Q | HNSC | 1 |
p.D1082N | ESCA | 1 |
p.L963V | BLCA | 1 |
p.V172M | HNSC | 1 |
p.G389R | LIHC | 1 |
p.G908E | SKCM | 1 |
p.G1495C | PAAD | 1 |
p.I532T | SKCM | 1 |
p.K941R | SARC | 1 |
p.G41E | PAAD | 1 |
p.R1071Q | PAAD | 1 |
p.P129H | LUAD | 1 |
p.I1275N | LGG | 1 |
p.H153N | SKCM | 1 |
p.K1137R | STAD | 1 |
p.S456C | LUSC | 1 |
p.H1323Y | SKCM | 1 |
p.V1497I | SKCM | 1 |
p.D391N | UCS | 1 |
p.G1218R | PAAD | 1 |
p.S607Y | CESC | 1 |
p.R581Q | STAD | 1 |
p.E685K | SKCM | 1 |
p.W463C | STAD | 1 |
p.C832Y | LUSC | 1 |
p.E1397Q | CESC | 1 |
p.C1530Y | ESCA | 1 |
p.A1485T | UCEC | 1 |
p.F928L | UCEC | 1 |
p.T81M | COAD | 1 |
p.F1391L | UCS | 1 |
p.H1609P | BRCA | 1 |
p.L1357V | LUAD | 1 |
p.I820V | COAD | 1 |
p.A591T | LGG | 1 |
p.R17Q | BLCA | 1 |
p.R927Q | UCEC | 1 |
p.R1360T | SARC | 1 |
p.P923T | BLCA | 1 |
p.C1438Y | ESCA | 1 |
p.V80M | HNSC | 1 |
p.G1197S | SKCM | 1 |
p.F1037L | UCEC | 1 |
p.A56V | HNSC | 1 |
p.G1587C | PAAD | 1 |
p.E467D | UCEC | 1 |
p.N1148S | SKCM | 1 |
p.E647Q | BLCA | 1 |
p.H127L | KIRP | 1 |
p.P1415T | LUAD | 1 |
p.D99E | KIRP | 1 |
p.P167S | SKCM | 1 |
p.R933C | SKCM | 1 |
p.S1258C | LUAD | 1 |
p.A439S | PAAD | 1 |
p.E667K | SKCM | 1 |
p.R955C | GBM | 1 |
p.D589H | LUAD | 1 |
p.R576X | STAD | 1 |
p.A68S | LUAD | 1 |
p.R874W | UCEC | 1 |
p.E830K | ESCA | 1 |
p.E358K | UCEC | 1 |
p.D1231G | SKCM | 1 |
p.F1299L | UCS | 1 |
p.K234* | SKCM | 1 |
p.F564C | BLCA | 1 |
p.R66S | LAML | 1 |
p.P642L | SKCM | 1 |
p.S452L | SKCM | 1 |
p.H1262Y | SKCM | 1 |
p.F884V | READ | 1 |
p.I1190N | PAAD | 1 |
p.Q283H | LUSC | 1 |
p.V1606M | STAD | 1 |
p.R570L | LUAD | 1 |
p.D990N | ESCA | 1 |
p.P1074H | PRAD | 1 |
p.R803C | SKCM | 1 |
p.I1066V | UCEC | 1 |
p.D704N | STAD | 1 |
p.E1026K | COAD | 1 |
p.S49A | LUAD | 1 |
p.C731G | STAD | 1 |
p.E5Q | BLCA | 1 |
p.C141R | LGG | 1 |
p.K348N | READ | 1 |
p.D704N | UCEC | 1 |
p.S1562* | CESC | 1 |
p.R576* | STAD | 1 |
p.I938L | BLCA | 1 |
p.G1174S | SKCM | 1 |
p.Q1592E | BLCA | 1 |
p.A685V | UCEC | 1 |
p.E936K | SKCM | 1 |
p.E1306K | SKCM | 1 |
p.E922K | ESCA | 1 |
p.R516Q | LUAD | 1 |
p.R742C | SKCM | 1 |
p.L504F | CESC | 1 |
p.M178I | LUAD | 1 |
p.V700I | KIRP | 1 |
p.I1336N | LGG | 1 |
p.M1236I | BLCA | 1 |
p.L1383F | ESCA | 1 |
p.S1449F | SKCM | 1 |
p.A221V | SKCM | 1 |
p.E1490K | SKCM | 1 |
p.L726M | UCEC | 1 |
p.G969S | BLCA | 1 |
p.L156F | SKCM | 1 |
p.A1162T | PCPG | 1 |
p.R14W | LUAD | 1 |
p.R581Q | UCEC | 1 |
p.L1296I | READ | 1 |
p.A1339V | SKCM | 1 |
p.P930S | SARC | 1 |
p.S825F | BLCA | 1 |
p.P901S | SKCM | 1 |
p.Y1388D | UCEC | 1 |
p.N886K | BRCA | 1 |
p.D135Y | LUAD | 1 |
p.E875K | SKCM | 1 |
p.V357G | LGG | 1 |
p.A148V | HNSC | 1 |
p.P901L | STAD | 1 |
p.G27R | SKCM | 1 |
p.E261K | SKCM | 1 |
p.V1041I | STAD | 1 |
p.N597S | LIHC | 1 |
p.N2T | PAAD | 1 |
p.H1073Y | SKCM | 1 |
p.H92N | SKCM | 1 |
p.R142* | PAAD | 1 |
p.K855N | SKCM | 1 |
p.E400D | CESC | 1 |
p.H35L | KIRP | 1 |
p.S1488C | BRCA | 1 |
p.R50* | LGG | 1 |
p.P1507T | CHOL | 1 |
p.M527T | STAD | 1 |
p.G1310R | PAAD | 1 |
p.E827* | KIRC | 1 |
p.L1285I | LUSC | 1 |
p.R489Q | STAD | 1 |
p.Q223* | SKCM | 1 |
p.R1097Q | BLCA | 1 |
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TissGeneCNV for ADCY10 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ADCY10 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-C8-A12L-01A | ESRRG-ADCY10 | 5UTR-CDS | Chr1:217038403 | Chr1:167794093 |
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TissGeneNet for ADCY10 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ADCY10 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ADCY10 |
TissGeneDrug for ADCY10 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ADCY10 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0345407 | OSTEOPETROSIS, AUTOSOMAL RECESSIVE 3 | 3 | BeFree |
umls:C0029456 | Osteoporosis | 2 | BeFree,GAD |
umls:C0001430 | Adenoma | 1 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | GAD |
umls:C0029454 | Osteopetrosis | 1 | BeFree |
umls:C0033806 | Pseudohypoparathyroidism | 1 | BeFree |
umls:C0033860 | Psoriasis | 1 | BeFree |
umls:C0037274 | Dermatologic disorders | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0280324 | Laryngeal Squamous Cell Carcinoma | 1 | BeFree |
umls:C0595921 | Intraocular pressure disorder | 1 | BeFree |
umls:C0595936 | Aqueous Humor Disorders | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | BeFree |
umls:C2931404 | Albright's hereditary osteodystrophy | 1 | BeFree |
umls:C3494506 | Pseudohypoparathyroidism, Type Ia | 1 | BeFree |
umls:C0342639 | Familial idiopathic hypercalciuria | 0 | CTD_human |