TissGeneSummary for NXF3 |
Gene summary |
Basic gene information | Gene symbol | NXF3 |
Gene name | nuclear RNA export factor 3 | |
Synonyms | - | |
Cytomap | UCSC genome browser: Xq22 | |
Type of gene | protein-coding | |
RefGenes | NM_022052.1, | |
Description | TAP-like protein 3TAPL-3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 300316 | |
HGNC : HGNC | ||
Ensembl : ENSG00000147206 | ||
HPRD : 02261 | ||
Vega : OTTHUMG00000022088 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NXF3 | |
BioGPS: 56000 | ||
Pathway | NCI Pathway Interaction Database: NXF3 | |
KEGG: NXF3 | ||
REACTOME: NXF3 | ||
Pathway Commons: NXF3 | ||
Context | iHOP: NXF3 | |
ligand binding site mutation search in PubMed: NXF3 | ||
UCL Cancer Institute: NXF3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryStomachTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVSTADTGCT | |
Reference showing the relevant tissue of NXF3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006406 | mRNA export from nucleus | 11545741 | GO:0006406 | mRNA export from nucleus | 11545741 |
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TissGeneExp for NXF3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.585382549 | 4.001554706 | -4.586937255 | 3.04E-33 | 2.63E-31 |
LIHC | -1.444819921 | 1.831176079 | -3.275996 | 2.02E-22 | 2.04E-20 |
LUAD | -0.166208749 | 3.71070332 | -3.876912069 | 3.60E-26 | 1.88E-24 |
KICH | -1.818293921 | -0.323661921 | -1.494632 | 3.71E-06 | 1.26E-05 |
KIRC | -1.201181977 | -0.020193088 | -1.180988889 | 3.47E-08 | 1.00E-07 |
STAD | 0.930054829 | -0.615026421 | 1.54508125 | 0.00693 | 0.025425073 |
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TissGene-miRNA for NXF3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NXF3 |
TissGeneSNV for NXF3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E136K | SKCM | 2 |
p.H56Y | UCEC | 1 |
p.E93K | SKCM | 1 |
p.E91V | THCA | 1 |
p.V88I | COAD | 1 |
p.E91K | HNSC | 1 |
p.S481N | SKCM | 1 |
p.S72L | SKCM | 1 |
p.D236N | SKCM | 1 |
p.A20T | UCEC | 1 |
p.R17K | SKCM | 1 |
p.K326N | LIHC | 1 |
p.P191H | LUAD | 1 |
p.V142I | LGG | 1 |
p.E301K | SKCM | 1 |
p.H59D | LUAD | 1 |
p.G40D | STAD | 1 |
p.E126K | SKCM | 1 |
p.V378M | BRCA | 1 |
p.K127N | BLCA | 1 |
p.G466C | LUAD | 1 |
p.L132F | BRCA | 1 |
p.E201Q | BRCA | 1 |
p.K77R | SKCM | 1 |
p.D281E | BLCA | 1 |
p.S34F | CESC | 1 |
p.K332R | STAD | 1 |
p.A165V | CESC | 1 |
p.G455E | SKCM | 1 |
p.P226H | CESC | 1 |
p.L221I | UCEC | 1 |
p.P96H | READ | 1 |
p.V253I | KIRP | 1 |
p.D405Y | STAD | 1 |
p.N104K | LUAD | 1 |
p.R76W | SKCM | 1 |
p.S213C | HNSC | 1 |
p.T497I | HNSC | 1 |
p.P329Q | LUSC | 1 |
p.S2* | ESCA | 1 |
p.L492H | HNSC | 1 |
p.K342N | SKCM | 1 |
p.T288A | STAD | 1 |
p.H147Y | SKCM | 1 |
p.S504N | HNSC | 1 |
p.D396H | LUAD | 1 |
p.R81C | UCEC | 1 |
p.F394L | BLCA | 1 |
p.S2X | ESCA | 1 |
p.C279W | HNSC | 1 |
p.E266K | HNSC | 1 |
p.T287M | GBM | 1 |
p.E371* | UCEC | 1 |
p.P230L | CESC | 1 |
p.C308* | UCEC | 1 |
p.A240E | LIHC | 1 |
p.Y148N | LIHC | 1 |
p.N399D | UCEC | 1 |
p.P97A | BRCA | 1 |
p.E371Q | BLCA | 1 |
p.G455V | LGG | 1 |
p.S283R | STAD | 1 |
p.Y66C | UCEC | 1 |
p.A165T | COAD | 1 |
p.P73L | PCPG | 1 |
p.R361* | SKCM | 1 |
p.A317T | UCEC | 1 |
p.P15L | LUAD | 1 |
p.D419Y | UCEC | 1 |
p.Q350H | READ | 1 |
p.W113* | SKCM | 1 |
p.W113S | GBM | 1 |
p.E93G | OV | 1 |
p.S241L | COAD | 1 |
p.V488M | KIRP | 1 |
p.L509I | LUAD | 1 |
p.R361X | SKCM | 1 |
p.G466D | SKCM | 1 |
p.Q213* | PRAD | 1 |
p.S293C | BLCA | 1 |
p.G272W | SKCM | 1 |
p.H415Q | LUAD | 1 |
p.P106L | LGG | 1 |
p.Q213X | PRAD | 1 |
p.Y368* | LUAD | 1 |
p.P119L | KIRC | 1 |
p.R225S | BLCA | 1 |
p.K95* | BLCA | 1 |
p.L365I | LUAD | 1 |
p.G455R | LIHC | 1 |
p.S161N | SKCM | 1 |
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TissGeneCNV for NXF3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NXF3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AK294826 | NXF3-GOLGA8A | chrX:102335584 | chr15:34673608 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-S3-A6ZF-01A | RNF44-NXF3 | 5UTR-CDS | Chr5:175964732 | ChrX:102339423 |
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TissGeneNet for NXF3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NXF3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NXF3 |
TissGeneDrug for NXF3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NXF3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0008925 | Cleft Palate | 1 | BeFree |