TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PROC

Gene summary

Basic gene information	Gene symbol	PROC
	Gene name	protein C (inactivator of coagulation factors Va and VIIIa)
	Synonyms	APC\|PC\|PROC1\|THPH3\|THPH4
	Cytomap	UCSC genome browser: 2q13-q14
	Type of gene	protein-coding
	RefGenes	NM_000312.3,
	Description	anticoagulant protein Cautoprothrombin IIAblood coagulation factor XIVprepro-protein Cvitamin K-dependent protein C
	Modification date	20141207
dbXrefs	MIM : 612283
	HGNC : HGNC
	Ensembl : ENSG00000115718
	HPRD : 01466
	Vega : OTTHUMG00000131528
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PROC
	BioGPS: 5624
Pathway	NCI Pathway Interaction Database: PROC
	KEGG: PROC
	REACTOME: PROC
	Pathway Commons: PROC
Context	iHOP: PROC
	ligand binding site mutation search in PubMed: PROC
	UCL Cancer Institute: PROC
Assigned class in TissGDB*	A
Included tissue-specific gene expression resources	HPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LIHC
Reference showing the relevant tissue of PROC	Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice. Oka K, Kobayashi K, Sullivan M, Martinez J, Teng BB, Ishimura-Oka K, Chan L. J Biol Chem. 1997 Jan 17;272(3):1456-60. (pmid:8999814) go to article
Description by TissGene annotations	Cancer gene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO term

PubMed ID

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TissGeneExp for PROC

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
THCA	-0.190283638	-2.30964635	2.119362712	5.96E-14	6.25E-13
LUSC	-0.415359743	-1.914412684	1.499052941	1.21E-09	4.11E-09
LUAD	-0.238883813	-2.102814848	1.863931034	4.97E-11	3.10E-10
KICH	-2.609001469	2.870018531	-5.47902	1.26E-15	2.95E-14
KIRC	0.390307087	2.921076531	-2.530769444	6.49E-12	2.57E-11
BRCA	-1.009064697	-3.097613819	2.088549123	1.05E-36	2.15E-35
LIHC	8.366878531	9.580704531	-1.213826	2.30E-07	1.46E-06
HNSC	0.609493973	-1.551424631	2.160918605	1.04E-08	1.26E-07
BLCA	0.565889689	-1.39714189	1.963031579	0.00204	0.012962743
KIRP	1.674495281	3.950276531	-2.27578125	0.000691	0.001981102
STAD	1.166614031	-0.852992219	2.01960625	0.000174	0.001242305

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TissGene-miRNA for PROC

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for PROC

TissGeneSNV for PROC

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.E92K	SKCM	2
p.R254Q	SKCM	2
p.H503Y	PAAD	1
p.R38W	DLBC	1
p.K512Q	KIRC	1
p.S232T	LIHC	1
p.L303R	UCEC	1
p.E382K	SKCM	1
p.V359I	UCEC	1
p.M22R	SKCM	1
p.P376L	PRAD	1
p.D334E	KIRC	1
p.E71K	SKCM	1
p.M380V	STAD	1
p.P424S	SKCM	1
p.L357R	HNSC	1
p.R440H	UCEC	1
p.A364T	LUAD	1
p.K290N	LUAD	1
p.G221E	SKCM	1
p.W444X	SKCM	1
p.R211W	ESCA	1
p.S164L	UCEC	1
p.G276E	SKCM	1
p.D279E	KIRC	1
p.E454K	SKCM	1
p.K457Q	KIRC	1
p.W328*	SKCM	1
p.G36R	SKCM	1
p.M310I	SKCM	1
p.A452V	PRAD	1
p.P182S	SKCM	1
p.V434I	READ	1
p.C238*	LUAD	1
p.R327C	ACC	1
p.A454T	SKCM	1
p.E69Q	BLCA	1
p.E89K	SKCM	1
p.A301T	COAD	1
p.W499*	SKCM	1
p.L303R	SKCM	1
p.P369S	SKCM	1
p.A301T	STAD	1
p.R409K	SKCM	1
p.E68K	SKCM	1
p.R272C	ACC	1
p.M255I	SKCM	1
p.L358R	SKCM	1
p.H448Y	PAAD	1
p.P237S	SKCM	1
p.A509T	SKCM	1
p.K314N	BLCA	1
p.E327K	SKCM	1
p.N431S	LIHC	1
p.M406V	BRCA	1
p.P369L	STAD	1
p.R272C	UCEC	1
p.Q95*	LUAD	1
p.G15R	SKCM	1
p.G467S	SKCM	1

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TissGeneCNV for PROC

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for PROC

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database

Src

Cancer type

Sample

Fusion gene

ORF

5'-gene BP

3'-gene BP

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TissGeneNet for PROC

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (tumor)	PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (normal)

COAD (tumor)	COAD (normal)
PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (tumor)	PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (normal)

HNSC (tumor)	HNSC (normal)
PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (tumor)	PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (normal)

KICH (tumor)	KICH (normal)
PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (tumor)	PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (normal)

KIRC (tumor)	KIRC (normal)
PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (tumor)	PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (normal)

KIRP (tumor)	KIRP (normal)
PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (tumor)	PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (normal)

LIHC (tumor)	LIHC (normal)
PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (tumor)	PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (normal)

LUAD (tumor)	LUAD (normal)
PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (tumor)	PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (normal)

LUSC (tumor)	LUSC (normal)
PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (tumor)	PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (normal)

PRAD (tumor)	PRAD (normal)
PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (tumor)	PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (normal)

STAD (tumor)	STAD (normal)
PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (tumor)	PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (normal)

THCA (tumor)	THCA (normal)
PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (tumor)	PROC, TK1, CSNK2B, SERPINB6, F2, F5, SERPINA5, PROS1, THBD, GGCX, PF4, F8, PROCR, CP, MMP15 (normal)

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TissGeneProg for PROC

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for PROC

TissGeneDrug for PROC

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for PROC

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0032580	Adenomatous Polyposis Coli	374	BeFree
umls:C1527249	Colorectal Cancer	191	BeFree
umls:C0009402	Colorectal Carcinoma	189	BeFree
umls:C0596263	Carcinogenesis	134	BeFree
umls:C0001430	Adenoma	101	BeFree
umls:C0007102	Malignant tumor of colon	80	BeFree
umls:C0699790	Colon Carcinoma	73	BeFree
umls:C0009404	Colorectal Neoplasms	49	BeFree
umls:C0001418	Adenocarcinoma	43	BeFree
umls:C0032584	polyps	41	BeFree
umls:C0334108	Multiple polyps	38	BeFree
umls:C1302401	Adenoma of large intestine	36	BeFree
umls:C0006142	Malignant neoplasm of breast	30	BeFree
umls:C0678222	Breast Carcinoma	29	BeFree
umls:C0079218	Fibromatosis, Aggressive	28	BeFree
umls:C0009375	Colonic Neoplasms	27	BeFree
umls:C0699791	Stomach Carcinoma	27	BeFree
umls:C0024623	Malignant neoplasm of stomach	25	BeFree
umls:C0600433	Activated Protein C Resistance	24	BeFree,GAD,LHGDN
umls:C1333990	Hereditary Nonpolyposis Colorectal Cancer	23	BeFree
umls:C2674616	FAMILIAL ADENOMATOUS POLYPOSIS, ATTENUATED (disorder)	22	BeFree
umls:C2239176	Liver carcinoma	21	BeFree
umls:C1861171	THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder)	20	BeFree
umls:C0398625	Protein C Deficiency	19	BeFree,CTD_human,GAD,LHGDN
umls:C0007137	Squamous cell carcinoma	15	BeFree
umls:C0178874	Tumor Progression	14	BeFree
umls:C0376358	Malignant neoplasm of prostate	14	BeFree
umls:C0600139	Prostate carcinoma	14	BeFree
umls:C2674321	Thrombophilia, Hereditary, Due To Protein C Deficiency, Autosomal Dominant	14	CLINVAR,UNIPROT
umls:C0242379	Malignant neoplasm of lung	13	BeFree
umls:C0007131	Non-Small Cell Lung Carcinoma	12	BeFree
umls:C0025149	Medulloblastoma	12	BeFree
umls:C0027627	Neoplasm Metastasis	12	BeFree
umls:C0206624	Hepatoblastoma	12	BeFree
umls:C0333983	Hyperplastic Polyp	12	BeFree
umls:C0021846	Intestinal Polyps	11	BeFree
umls:C0040053	Thrombosis	11	CTD_human,GAD,LHGDN
umls:C0398623	Thrombophilia	11	BeFree,GAD,LHGDN
umls:C0021841	Intestinal Neoplasms	10	BeFree
umls:C0042487	Venous Thrombosis	10	CTD_human,GAD,LHGDN
umls:C0206677	Adenomatous Polyps	10	BeFree
umls:C0684249	Carcinoma of lung	10	BeFree
umls:C0549473	Thyroid carcinoma	9	BeFree
umls:C3272841	MUTYH-Associate Polyposis	9	BeFree
umls:C0584960	Factor V Leiden mutation	8	BeFree
umls:C0949059	Polyp of large intestine	8	BeFree
umls:C0007113	Rectal Carcinoma	7	BeFree
umls:C0243026	Sepsis	7	BeFree,CTD_human,GAD,LHGDN
umls:C0346647	Malignant neoplasm of pancreas	7	BeFree
umls:C0009376	Colonic Polyps	6	BeFree
umls:C0017097	Gardner Syndrome	6	BeFree
umls:C0025202	melanoma	6	BeFree
umls:C0235974	Pancreatic carcinoma	6	BeFree
umls:C0265325	Turcot syndrome (disorder)	6	BeFree
umls:C0699885	Carcinoma of bladder	6	BeFree
umls:C1861172	Venous Thromboembolism	6	CTD_human,GAD,LHGDN
umls:C2676759	THROMBOPHILIA DUE TO PROTEIN C DEFICIENCY, AUTOSOMAL RECESSIVE	6	CLINVAR,CTD_human,UNIPROT
umls:C0005684	Malignant neoplasm of urinary bladder	5	BeFree
umls:C0021368	Inflammation	5	GAD,LHGDN
umls:C0023903	Liver neoplasms	5	BeFree
umls:C0032927	Precancerous Conditions	5	BeFree
umls:C0238463	Papillary thyroid carcinoma	5	BeFree
umls:C0334294	Multiple adenomatous polyps	5	BeFree
umls:C0003873	Rheumatoid Arthritis	4	BeFree,LHGDN
umls:C0006118	Brain Neoplasms	4	BeFree
umls:C0008626	Congenital chromosomal disease	4	BeFree
umls:C0016048	Fibromatosis	4	BeFree
umls:C0021390	Inflammatory Bowel Diseases	4	BeFree,LHGDN
umls:C0034341	Pyruvate Carboxylase Deficiency Disease	4	BeFree
umls:C0040038	Thromboembolism	4	BeFree,CTD_human,GAD
umls:C0149871	Deep Vein Thrombosis	4	BeFree,GAD
umls:C0279628	Adenocarcinoma Of Esophagus	4	BeFree
umls:C0311370	Lupus anticoagulant disorder	4	BeFree
umls:C0332887	Congenital hypertrophy	4	BeFree
umls:C0339555	Congenital hypertrophy of retinal pigment epithelium	4	BeFree
umls:C0476089	Endometrial Carcinoma	4	BeFree
umls:C0850572	Adenomatous polyp of colon	4	BeFree
umls:C1851124	Desmoid disease, hereditary	4	BeFree
umls:C0007103	Malignant neoplasm of endometrium	3	BeFree
umls:C0007134	Renal Cell Carcinoma	3	BeFree
umls:C0007222	Cardiovascular Diseases	3	BeFree,GAD
umls:C0009324	Ulcerative Colitis	3	BeFree
umls:C0014859	Esophageal Neoplasms	3	BeFree
umls:C0019163	Hepatitis B	3	BeFree
umls:C0026766	Multiple Organ Failure	3	GAD,LHGDN
umls:C0029925	Ovarian Carcinoma	3	BeFree
umls:C0034887	Rectal polyp	3	BeFree
umls:C0035335	Retinoblastoma	3	BeFree
umls:C0038356	Stomach Neoplasms	3	BeFree
umls:C0149678	Epstein-Barr Virus Infections	3	BeFree
umls:C0149826	Gastric adenoma	3	BeFree
umls:C0149925	Small cell carcinoma of lung	3	BeFree
umls:C0206685	Acinar Cell Carcinoma	3	BeFree
umls:C0206698	Cholangiocarcinoma	3	BeFree
umls:C0346627	Intestinal Cancer	3	BeFree
umls:C0546837	Malignant neoplasm of esophagus	3	BeFree
umls:C0685938	Malignant neoplasm of gastrointestinal tract	3	BeFree
umls:C0686619	Secondary malignant neoplasm of lymph node	3	BeFree
umls:C0920184	Fundic gland polyp	3	BeFree
umls:C1266025	Traditional Serrated Adenoma	3	BeFree
umls:C1883486	Uterine Corpus Cancer	3	BeFree
umls:C0004153	Atherosclerosis	2	BeFree,GAD
umls:C0004763	Barrett Esophagus	2	BeFree
umls:C0007095	Carcinoid Tumor	2	BeFree
umls:C0007115	Malignant neoplasm of thyroid	2	BeFree
umls:C0007129	Merkel cell carcinoma	2	BeFree
umls:C0010068	Coronary heart disease	2	BeFree,GAD,LHGDN
umls:C0011854	Diabetes Mellitus, Insulin-Dependent	2	BeFree
umls:C0014173	Endometrial Hyperplasia	2	BeFree
umls:C0017185	Gastrointestinal Neoplasms	2	BeFree
umls:C0018133	Graft-vs-Host Disease	2	BeFree
umls:C0023434	Chronic Lymphocytic Leukemia	2	BeFree
umls:C0023890	Liver Cirrhosis	2	BeFree
umls:C0027708	Nephroblastoma	2	BeFree
umls:C0029440	Osteoma	2	BeFree
umls:C0030521	Parathyroid Neoplasms	2	BeFree
umls:C0036690	Septicemia	2	BeFree
umls:C0037579	Soft Tissue Neoplasms	2	BeFree
umls:C0038454	Cerebrovascular accident	2	BeFree,GAD
umls:C0042769	Virus Diseases	2	BeFree
umls:C0085650	Purpura Fulminans	2	BeFree,CTD_human
umls:C0151779	Cutaneous Melanoma	2	BeFree
umls:C0151950	Deep thrombophlebitis	2	BeFree
umls:C0152018	Esophageal carcinoma	2	BeFree
umls:C0175754	Agenesis of corpus callosum	2	BeFree
umls:C0242666	Protein S Deficiency	2	BeFree
umls:C0260037	Multiple tumors	2	BeFree
umls:C0278803	Adenocarcinoma of small intestine	2	BeFree
umls:C0279626	Squamous cell carcinoma of esophagus	2	BeFree
umls:C0334092	Hamartomatous polyp	2	BeFree
umls:C0338106	Adenocarcinoma of colon	2	BeFree
umls:C0345893	Juvenile polyposis syndrome	2	BeFree
umls:C0345967	Malignant mesothelioma	2	BeFree
umls:C0494165	Secondary malignant neoplasm of liver	2	BeFree
umls:C0598608	Hyperhomocysteinemia	2	BeFree,LHGDN
umls:C0750974	Brain Tumor, Primary	2	BeFree
umls:C0850666	Helicobacter pylori infection	2	BeFree
umls:C0940937	precancerous lesions	2	BeFree
umls:C1266005	Basaloid squamous cell carcinoma	2	BeFree
umls:C1274290	Neonatal purpura fulminans (homozygous protein C deficiency)	2	BeFree
umls:C1512409	Hepatocarcinogenesis	2	BeFree
umls:C1512981	Mammary Tumorigenesis	2	BeFree
umls:C1868001	Polyposis Of Gastric Fundus Without Polyposis Coli	2	BeFree
umls:C1868081	Juvenile Polyposis Coli	2	BeFree
umls:C3811653	Experimental Organism Basal Cell Carcinoma	2	BeFree
umls:C0001618	Tumors of Adrenal Cortex	1	BeFree
umls:C0001815	Primary Myelofibrosis	1	BeFree
umls:C0002448	Ameloblastoma	1	BeFree
umls:C0002690	Amputation Stumps	1	BeFree
umls:C0002793	Anaplasia	1	BeFree
umls:C0003469	Anxiety Disorders	1	BeFree
umls:C0003860	Arteritis	1	CTD_human
umls:C0004364	Autoimmune Diseases	1	BeFree
umls:C0004779	Basal Cell Nevus Syndrome	1	BeFree
umls:C0004903	Beckwith-Wiedemann Syndrome	1	BeFree
umls:C0004936	Mental disorders	1	BeFree
umls:C0005695	Bladder Neoplasm	1	BeFree
umls:C0006145	Breast Diseases	1	BeFree
umls:C0007130	Mucinous Adenocarcinoma	1	BeFree
umls:C0007570	Celiac Disease	1	BeFree
umls:C0007847	Malignant tumor of cervix	1	BeFree
umls:C0008495	Chorioamnionitis	1	GAD
umls:C0009319	Colitis	1	BeFree
umls:C0010346	Crohn Disease	1	BeFree
umls:C0011847	Diabetes	1	BeFree
umls:C0011849	Diabetes Mellitus	1	BeFree
umls:C0011881	Diabetic Nephropathy	1	LHGDN
umls:C0012739	Disseminated Intravascular Coagulation	1	CTD_human
umls:C0014072	Experimental Autoimmune Encephalomyelitis	1	BeFree
umls:C0014511	Epithelial cyst	1	BeFree
umls:C0015944	Fetal Membranes, Premature Rupture	1	GAD
umls:C0017150	Gastrinoma	1	BeFree
umls:C0018843	Heat Stroke	1	LHGDN
umls:C0019158	Hepatitis	1	BeFree
umls:C0019159	Hepatitis A	1	BeFree
umls:C0019348	Herpes Simplex Infections	1	BeFree
umls:C0020428	Hyperaldosteronism	1	BeFree
umls:C0020538	Hypertensive disease	1	CTD_human
umls:C0020542	Pulmonary Hypertension	1	BeFree
umls:C0021933	Intussusception	1	BeFree
umls:C0022521	Kartagener Syndrome	1	BeFree
umls:C0022603	Seborrheic keratosis	1	BeFree
umls:C0022876	Premature Obstetric Labor	1	GAD
umls:C0024121	Lung Neoplasms	1	BeFree
umls:C0024299	Lymphoma	1	BeFree
umls:C0024534	Malaria, Cerebral	1	BeFree
umls:C0026850	Muscular Dystrophy	1	BeFree
umls:C0026987	Myelofibrosis	1	BeFree
umls:C0028880	Odontogenic Tumors	1	BeFree
umls:C0028945	oligodendroglioma	1	BeFree
umls:C0029463	Osteosarcoma	1	BeFree
umls:C0030297	Pancreatic Neoplasm	1	BeFree
umls:C0030305	Pancreatitis	1	LHGDN
umls:C0031269	Peutz-Jeghers Syndrome	1	BeFree
umls:C0032000	Pituitary Adenoma	1	BeFree
umls:C0032914	Pre-Eclampsia	1	GAD
umls:C0033822	Pseudomyxoma Peritonei	1	BeFree
umls:C0033860	Psoriasis	1	BeFree
umls:C0034882	Rectal Diseases	1	BeFree
umls:C0034885	Rectal Neoplasms	1	BeFree
umls:C0037889	Hereditary spherocytosis	1	BeFree
umls:C0039101	synovial sarcoma	1	BeFree
umls:C0040136	Thyroid Neoplasm	1	BeFree
umls:C0041341	Tuberous Sclerosis	1	BeFree
umls:C0041948	Uremia	1	LHGDN
umls:C0079744	Diffuse Large B-Cell Lymphoma	1	BeFree
umls:C0085096	Peripheral Vascular Diseases	1	GAD
umls:C0085136	Central Nervous System Neoplasms	1	BeFree
umls:C0086692	Benign Neoplasm	1	BeFree
umls:C0086981	Sicca Syndrome	1	BeFree
umls:C0151526	Premature Birth	1	GAD
umls:C0153381	Malignant neoplasm of mouth	1	BeFree
umls:C0153453	Malignant tumor of extrahepatic bile duct	1	BeFree
umls:C0153594	Malignant neoplasm of testis	1	BeFree
umls:C0155773	Portal vein thrombosis	1	BeFree
umls:C0162871	Aortic Aneurysm, Abdominal	1	LHGDN
umls:C0205851	Germ cell tumor	1	BeFree
umls:C0206645	Desmoplastic fibroma	1	BeFree
umls:C0206646	Fibromatosis, Abdominal	1	BeFree
umls:C0206686	Adrenocortical carcinoma	1	BeFree
umls:C0206687	Carcinoma, Endometrioid	1	BeFree
umls:C0206696	Carcinoma, Signet Ring Cell	1	BeFree
umls:C0206708	Cervical Intraepithelial Neoplasia	1	BeFree
umls:C0206715	Neoplasms, Neuroepithelial	1	BeFree
umls:C0206754	Neuroendocrine Tumors	1	BeFree
umls:C0220620	Gastrointestinal Carcinoid Tumor	1	BeFree
umls:C0220633	Uveal melanoma	1	BeFree
umls:C0220641	Lip and Oral Cavity Carcinoma	1	BeFree
umls:C0220650	Metastatic malignant neoplasm to brain	1	BeFree
umls:C0221273	Juvenile polyp	1	BeFree
umls:C0238019	Carcinoma of extrahepatic bile duct	1	BeFree
umls:C0238198	Gastrointestinal Stromal Tumors	1	BeFree
umls:C0238461	Anaplastic thyroid carcinoma	1	BeFree
umls:C0242994	Hantavirus Infections	1	BeFree
umls:C0262587	Parathyroid Adenoma	1	BeFree
umls:C0265101	Carotid artery occlusion	1	BeFree
umls:C0278601	Inflammatory Breast Carcinoma	1	BeFree
umls:C0279637	Anal carcinoma	1	BeFree
umls:C0279661	Acinar cell carcinoma of pancreas	1	BeFree
umls:C0281361	Adenocarcinoma of pancreas	1	BeFree
umls:C0282193	Iron Overload	1	BeFree
umls:C0302592	Cervix carcinoma	1	BeFree
umls:C0334287	Fibrolamellar hepatocellular carcinoma	1	BeFree
umls:C0334299	Carcinoid tumor no ICD-O subtype	1	BeFree
umls:C0334558	Malignant odontogenic tumor	1	BeFree
umls:C0334590	Anaplastic Oligodendroglioma	1	BeFree
umls:C0334699	Malignant myoepithelioma	1	BeFree
umls:C0345905	Intrahepatic Cholangiocarcinoma	1	BeFree
umls:C0346402	Malignant neoplasm of adrenal cortex	1	BeFree
umls:C0347266	Polyp of duodenum	1	BeFree
umls:C0349530	Early gastric cancer	1	BeFree
umls:C0349534	Carcinoma of anal margin	1	BeFree
umls:C0392514	Hereditary hemochromatosis	1	BeFree
umls:C0398621	Hypoplasminogenemia	1	BeFree
umls:C0432365	Thalidomide embryopathy syndrome	1	BeFree
umls:C0521158	Recurrent tumor	1	BeFree
umls:C0545074	Myxoid/Round Cell Liposarcoma	1	BeFree
umls:C0585442	Osteosarcoma of bone	1	BeFree
umls:C0598221	Hereditary protein C deficiency	1	GAD
umls:C0598766	Leukemogenesis	1	BeFree
umls:C0677886	Epithelial ovarian cancer	1	BeFree
umls:C0687150	Parathyroid Gland Adenocarcinoma	1	BeFree
umls:C0700636	Focal nodular hyperplasia of liver	1	BeFree
umls:C0751396	Well Differentiated Oligodendroglioma	1	BeFree
umls:C0751606	Adult Acute Lymphocytic Leukemia	1	BeFree
umls:C0796016	Microphthalmia, syndromic 1	1	BeFree
umls:C0851887	Adenoviral infections	1	BeFree
umls:C0854917	Rhabdoid Tumor of the Kidney	1	BeFree
umls:C0855197	Testicular malignant germ cell tumor	1	BeFree
umls:C0856169	Endothelial dysfunction	1	BeFree
umls:C0856825	Acute GVH disease	1	BeFree
umls:C0858970	Carcinogenicity	1	BeFree
umls:C0866188	Renal thrombosis	1	BeFree
umls:C0948089	Acute Coronary Syndrome	1	GAD
umls:C0948209	Intestinal adenocarcinoma	1	BeFree
umls:C0948441	Venoocclusive disease	1	BeFree
umls:C1168327	High-Grade Prostatic Intraepithelial Neoplasia	1	BeFree
umls:C1176475	Ductal Carcinoma	1	BeFree
umls:C1261473	Sarcoma	1	BeFree
umls:C1328504	Hormone refractory prostate cancer	1	BeFree
umls:C1333762	Gastric Cardia Adenocarcinoma	1	BeFree
umls:C1334274	Invasive Carcinoma	1	BeFree
umls:C1335177	Ovarian Serous Adenocarcinoma	1	BeFree
umls:C1335475	Primary Carcinoma	1	BeFree
umls:C1336905	Endometrial Endometrioid Adenocarcinoma	1	BeFree
umls:C1337011	Well Differentiated Pancreatic Endocrine Tumor	1	BeFree
umls:C1458155	Mammary Neoplasms	1	BeFree
umls:C1510431	Superficial thrombophlebitis	1	BeFree
umls:C1519680	Tumor Immunity	1	BeFree
umls:C1520166	Xenograft Model	1	BeFree
umls:C1527349	Ductal Breast Carcinoma	1	BeFree
umls:C1527408	Rectal Tumors	1	BeFree
umls:C1559154	Rash and Dermatitis Adverse Event Associated with Chemoradiation	1	BeFree
umls:C1623038	Cirrhosis	1	BeFree
umls:C1708187	Gardner fibroma	1	BeFree
umls:C1850343	MOSAIC VARIEGATED ANEUPLOIDY SYNDROME	1	BeFree
umls:C1851841	ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1	1	BeFree
umls:C1867596	Hyperprothrombinemia	1	BeFree
umls:C2608079	WARFARIN SENSITIVITY (disorder)	1	GAD
umls:C2674218	SPHEROCYTOSIS, TYPE 1 (disorder)	1	BeFree
umls:C2825306	Treatment related leukaemia	1	BeFree
umls:C2919032	Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified	1	GAD
umls:C2919828	Chronic ulcerative colitis	1	BeFree
umls:C2930896	Congenital thrombotic disease, due to Protein C deficiency	1	BeFree,CTD_human
umls:C2931822	Nasopharyngeal carcinoma	1	BeFree
umls:C3164780	Clinical sepsis	1	BeFree
umls:C3549742	Breast cancer, lobular	1	BeFree
umls:C3665444	Neutrophilia (disorder)	1	BeFree
umls:C3838965	Microcystic stromal tumor	1	BeFree