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| TissGeneSummary for C21orf62 |
 Gene summary |
| Basic gene information | Gene symbol | C21orf62 |
| Gene name | chromosome 21 open reading frame 62 | |
| Synonyms | B37|C21orf120|PRED81 | |
| Cytomap | UCSC genome browser: 21q22.11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001162495.2, NM_001162496.2,NM_019596.5, | |
| Description | uncharacterized protein C21orf62 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| HPRD : 10759 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C21orf62 | |
| BioGPS: 56245 | ||
| Pathway | NCI Pathway Interaction Database: C21orf62 | |
| KEGG: C21orf62 | ||
| REACTOME: C21orf62 | ||
| Pathway Commons: C21orf62 | ||
| Context | iHOP: C21orf62 | |
| ligand binding site mutation search in PubMed: C21orf62 | ||
| UCL Cancer Institute: C21orf62 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryPancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVPAAD | |
| Reference showing the relevant tissue of C21orf62 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for C21orf62 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 2.285752534 | 5.217740034 | -2.9319875 | 1.84E-15 | 9.55E-15 |
| LUSC | -2.924455799 | -1.775673446 | -1.148782353 | 3.45E-06 | 8.22E-06 |
| LIHC | -2.980014466 | 0.017069534 | -2.997084 | 6.31E-23 | 7.38E-21 |
| KICH | -2.044882466 | 5.065277534 | -7.11016 | 2.98E-25 | 6.57E-23 |
| BRCA | -2.820726852 | -1.630835624 | -1.189891228 | 6.13E-19 | 4.05E-18 |
| LUAD | -2.864165569 | -1.59817419 | -1.265991379 | 6.90E-08 | 2.75E-07 |
| PRAD | -0.888057081 | 0.973596765 | -1.861653846 | 1.90E-06 | 1.27E-05 |
| ESCA | -1.827540648 | 0.099222989 | -1.926763636 | 0.00129 | 0.017282892 |
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| TissGene-miRNA for C21orf62 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for C21orf62 |
| TissGeneSNV for C21orf62 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.F181L | SKCM | 2 |
| p.F181L | LGG | 2 |
| p.W161X | STAD | 1 |
| p.R73Q | UCEC | 1 |
| p.T97M | STAD | 1 |
| p.Q138H | UCEC | 1 |
| p.R126H | READ | 1 |
| p.T97M | KIRP | 1 |
| p.F181L | STAD | 1 |
| p.F181L | KIRP | 1 |
| p.V214A | LUAD | 1 |
| p.F181L | PAAD | 1 |
| p.S209I | UCEC | 1 |
| p.F181L | PRAD | 1 |
| p.R73* | PAAD | 1 |
| p.N210S | UCS | 1 |
| p.W161* | STAD | 1 |
| p.M60I | OV | 1 |
| p.K28R | LIHC | 1 |
| p.L9V | BLCA | 1 |
| p.D101N | SKCM | 1 |
| p.L106M | PRAD | 1 |
| p.L98V | ACC | 1 |
| p.R73X | PAAD | 1 |
| p.D147N | SKCM | 1 |
| p.R73Q | SKCM | 1 |
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| TissGeneCNV for C21orf62 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for C21orf62 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A158-01A | SYNJ1-C21orf62 | CDS-5UTR | Chr21:34037223 | Chr21:34182964 |
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| TissGeneNet for C21orf62 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for C21orf62 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for C21orf62 |
| TissGeneDrug for C21orf62 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for C21orf62 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0036341 | Schizophrenia | 2 | BeFree |
| umls:C0393578 | Pallidoluysian degeneration | 1 | BeFree |
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