TissGeneSummary for IRGC |
Gene summary |
Basic gene information | Gene symbol | IRGC |
Gene name | immunity-related GTPase family, cinema | |
Synonyms | CINEMA|IFGGE|IRGC1|Iigp5|R30953_1 | |
Cytomap | UCSC genome browser: 19q13.31 | |
Type of gene | protein-coding | |
RefGenes | NM_019612.3, | |
Description | immunity-related GTPase cinema 1immunity-related GTPase family, cinema 1interferon inducible GTPase 5interferon-gamma-inducible GTPase IFGGE proteininterferon-inducible GTPase 5 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000124449 | ||
HPRD : 15200 | ||
Vega : OTTHUMG00000154587 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IRGC | |
BioGPS: 56269 | ||
Pathway | NCI Pathway Interaction Database: IRGC | |
KEGG: IRGC | ||
REACTOME: IRGC | ||
Pathway Commons: IRGC | ||
Context | iHOP: IRGC | |
ligand binding site mutation search in PubMed: IRGC | ||
UCL Cancer Institute: IRGC | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of IRGC | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for IRGC |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for IRGC |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for IRGC |
TissGeneSNV for IRGC |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E78K | SKCM | 2 |
p.D235N | SKCM | 2 |
p.E193K | SKCM | 2 |
p.R222C | SKCM | 1 |
p.G353D | BLCA | 1 |
p.P98S | SKCM | 1 |
p.G431E | SKCM | 1 |
p.R75G | LUAD | 1 |
p.P226S | SKCM | 1 |
p.A205D | LIHC | 1 |
p.P96L | BRCA | 1 |
p.V207M | STAD | 1 |
p.S348F | LIHC | 1 |
p.D352N | STAD | 1 |
p.M262V | LUAD | 1 |
p.V276I | PRAD | 1 |
p.K127N | LUAD | 1 |
p.A380T | BRCA | 1 |
p.R143G | LUSC | 1 |
p.D130E | OV | 1 |
p.Y382F | LUAD | 1 |
p.P113R | KIRP | 1 |
p.R28H | UCEC | 1 |
p.R167C | HNSC | 1 |
p.R201W | STAD | 1 |
p.R241C | ACC | 1 |
p.K258N | SARC | 1 |
p.A205P | LUSC | 1 |
p.R299C | PRAD | 1 |
p.R144C | STAD | 1 |
p.A221T | STAD | 1 |
p.E200K | SKCM | 1 |
p.E424K | SKCM | 1 |
p.G422S | LUAD | 1 |
p.L55V | LUAD | 1 |
p.P182S | LUAD | 1 |
p.E408K | UCEC | 1 |
p.S339L | SKCM | 1 |
p.V9L | LUAD | 1 |
p.G431R | SKCM | 1 |
p.R359L | LUAD | 1 |
p.Y301H | STAD | 1 |
p.A26V | SKCM | 1 |
p.R75H | BLCA | 1 |
p.R345Q | BLCA | 1 |
p.P100L | SKCM | 1 |
p.P105S | SKCM | 1 |
p.A188T | SKCM | 1 |
p.S141P | TGCT | 1 |
p.Y289* | LUSC | 1 |
p.E200K | HNSC | 1 |
p.T177M | BLCA | 1 |
p.Y134C | ACC | 1 |
p.A189V | STAD | 1 |
p.L77P | STAD | 1 |
p.D81V | SKCM | 1 |
p.S348F | SKCM | 1 |
p.R144H | LIHC | 1 |
p.P118S | SKCM | 1 |
p.R203Q | COAD | 1 |
p.D406E | LUAD | 1 |
p.I295N | LUAD | 1 |
p.K449M | LUAD | 1 |
p.S219L | LUAD | 1 |
p.E14X | ESCA | 1 |
p.R400L | LUAD | 1 |
p.S247L | LUSC | 1 |
p.V89I | GBM | 1 |
p.A40T | BLCA | 1 |
p.S332F | SKCM | 1 |
p.F378C | LIHC | 1 |
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TissGeneCNV for IRGC |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IRGC |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for IRGC |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IRGC |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IRGC |
TissGeneDrug for IRGC |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IRGC |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |