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| TissGeneSummary for IL36G |
 Gene summary |
| Basic gene information | Gene symbol | IL36G |
| Gene name | interleukin 36, gamma | |
| Synonyms | IL-1F9|IL-1H1|IL-1RP2|IL1E|IL1F9|IL1H1|IL1RP2 | |
| Cytomap | UCSC genome browser: 2q12-q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001278568.1, NM_019618.3, | |
| Description | IL-1 epsilonIL-1 related protein 2IL-1(EPSILON)IL-1-epsilonIL-1-related protein 2interleukin 1 family, member 9interleukin 1-related protein 2interleukin-1 epsiloninterleukin-1 family member 9interleukin-1 homolog 1interleukin-36 gamma | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605542 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000136688 | ||
| HPRD : 05707 | ||
| Vega : OTTHUMG00000131336 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_IL36G | |
| BioGPS: 56300 | ||
| Pathway | NCI Pathway Interaction Database: IL36G | |
| KEGG: IL36G | ||
| REACTOME: IL36G | ||
| Pathway Commons: IL36G | ||
| Context | iHOP: IL36G | |
| ligand binding site mutation search in PubMed: IL36G | ||
| UCL Cancer Institute: IL36G | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADSKCM | |
| Reference showing the relevant tissue of IL36G | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for IL36G |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for IL36G |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for IL36G |
| TissGeneSNV for IL36G |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R47Q | SKCM | 2 |
| p.E112K | SKCM | 2 |
| p.R126M | LIHC | 1 |
| p.A8T | SKCM | 1 |
| p.P5S | SKCM | 1 |
| p.R121C | UCEC | 1 |
| p.I140N | LUAD | 1 |
| p.G78E | SKCM | 1 |
| p.E93K | SKCM | 1 |
| p.R71T | HNSC | 1 |
| p.V58F | LUAD | 1 |
| p.V114M | COAD | 1 |
| p.D73N | SKCM | 1 |
| p.G12E | SKCM | 1 |
| p.Q17X | SKCM | 1 |
| p.Q17* | SKCM | 1 |
| p.W35* | SKCM | 1 |
| p.R121H | READ | 1 |
| p.R121H | LUAD | 1 |
| p.A66D | UCEC | 1 |
| p.I149N | LGG | 1 |
| p.W35X | SKCM | 1 |
| p.L86F | LUAD | 1 |
| p.A141S | ESCA | 1 |
| p.R121H | STAD | 1 |
| p.W35L | UCS | 1 |
| p.G10V | ACC | 1 |
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| TissGeneCNV for IL36G |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for IL36G |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for IL36G |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for IL36G |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for IL36G |
| TissGeneDrug for IL36G |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for IL36G |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0003873 | Rheumatoid Arthritis | 1 | GAD |
| umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
| umls:C0038013 | Ankylosing spondylitis | 1 | GAD |
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