 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for PRSS1 |
 Gene summary |
| Basic gene information | Gene symbol | PRSS1 |
| Gene name | protease, serine, 1 (trypsin 1) | |
| Synonyms | TRP1|TRY1|TRY4|TRYP1 | |
| Cytomap | UCSC genome browser: 7q34 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002769.4, | |
| Description | beta-trypsincationic trypsinogendigestive zymogennonfunctional trypsin 1trypsin-1trypsinogen 1trypsinogen A | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 276000 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000204983 | ||
| HPRD : 02039 | ||
| Vega : OTTHUMG00000158923 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PRSS1 | |
| BioGPS: 5644 | ||
| Pathway | NCI Pathway Interaction Database: PRSS1 | |
| KEGG: PRSS1 | ||
| REACTOME: PRSS1 | ||
| Pathway Commons: PRSS1 | ||
| Context | iHOP: PRSS1 | |
| ligand binding site mutation search in PubMed: PRSS1 | ||
| UCL Cancer Institute: PRSS1 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
| Reference showing the relevant tissue of PRSS1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for PRSS1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | 2.749295978 | -1.208148022 | 3.957444 | 1.77E-06 | 6.43E-06 |
| LUSC | 1.47882139 | -0.487141355 | 1.965962745 | 1.38E-06 | 3.40E-06 |
| THCA | 2.390480114 | -0.954608022 | 3.345088136 | 1.76E-14 | 2.04E-13 |
| LUAD | 1.438502323 | -0.810571815 | 2.249074138 | 3.72E-06 | 1.14E-05 |
| PRAD | -1.13647533 | 0.336453517 | -1.472928846 | 0.000666 | 0.00224437 |
| COAD | 0.737618901 | -0.990196483 | 1.727815385 | 0.000171 | 0.00058909 |
| Top |
| TissGene-miRNA for PRSS1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for PRSS1 |
| TissGeneSNV for PRSS1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q209E | PCPG | 4 |
| p.I53N | KIRC | 4 |
| p.S229F | SKCM | 3 |
| p.G226R | SKCM | 3 |
| p.G97E | SKCM | 3 |
| p.G83E | SKCM | 2 |
| p.E55K | SKCM | 2 |
| p.V213I | UVM | 2 |
| p.D107N | HNSC | 2 |
| p.D21N | SKCM | 2 |
| p.D121N | HNSC | 2 |
| p.Q173H | LUAD | 2 |
| p.D218Y | KIRC | 2 |
| p.E171K | SKCM | 2 |
| p.C30Y | LUAD | 2 |
| p.C206S | PCPG | 2 |
| p.A121T | LUAD | 1 |
| p.D20N | SKCM | 1 |
| p.A259V | PAAD | 1 |
| p.N160Y | SKCM | 1 |
| p.G226E | SKCM | 1 |
| p.P226L | LIHC | 1 |
| p.P147S | SKCM | 1 |
| p.G212S | UCEC | 1 |
| p.E93D | SKCM | 1 |
| p.G74E | SKCM | 1 |
| p.Q98R | ESCA | 1 |
| p.V25A | PAAD | 1 |
| p.N160K | SARC | 1 |
| p.S209L | LUAD | 1 |
| p.Y189H | LUAD | 1 |
| p.L224I | LUAD | 1 |
| p.V137M | BLCA | 1 |
| p.Q70L | LIHC | 1 |
| p.G88E | SKCM | 1 |
| p.E157K | SKCM | 1 |
| p.Q38* | SKCM | 1 |
| p.I92V | HNSC | 1 |
| p.S195L | LUAD | 1 |
| p.N29K | LUAD | 1 |
| p.L4F | LUSC | 1 |
| p.A104T | PRAD | 1 |
| p.E85K | GBM | 1 |
| p.E79* | CESC | 1 |
| p.Q98K | KIRC | 1 |
| p.D153N | SKCM | 1 |
| p.G227X | ESCA | 1 |
| p.G157S | PRAD | 1 |
| p.A173P | LUAD | 1 |
| p.P3S | SKCM | 1 |
| p.A135T | LUAD | 1 |
| p.P111S | SKCM | 1 |
| p.M1I | SKCM | 1 |
| p.A177T | LGG | 1 |
| p.V179L | LUAD | 1 |
| p.D22N | SKCM | 1 |
| p.R95C | LUSC | 1 |
| p.V123M | THYM | 1 |
| p.G208V | UCEC | 1 |
| p.S34F | SKCM | 1 |
| p.L14V | ESCA | 1 |
| p.F73L | CESC | 1 |
| p.V137M | THYM | 1 |
| p.Q112R | ESCA | 1 |
| p.N77K | LUAD | 1 |
| p.E32K | BLCA | 1 |
| p.G212R | SKCM | 1 |
| p.R68H | UCEC | 1 |
| p.A148E | LUAD | 1 |
| p.N33K | STAD | 1 |
| p.N84I | SKCM | 1 |
| p.I108M | LUAD | 1 |
| p.E93K | SKCM | 1 |
| p.S129* | HNSC | 1 |
| p.P164S | LUAD | 1 |
| p.S215F | STAD | 1 |
| p.S215F | SKCM | 1 |
| p.S115* | HNSC | 1 |
| p.H46L | LUAD | 1 |
| p.P17L | SKCM | 1 |
| p.A15V | HNSC | 1 |
| p.N54K | LUAD | 1 |
| p.Q159H | LUAD | 1 |
| p.T149N | LUAD | 1 |
| p.A152T | UCEC | 1 |
| p.P111R | LUAD | 1 |
| p.L189F | SKCM | 1 |
| p.S60L | SKCM | 1 |
| p.A187P | LUAD | 1 |
| p.V137M | SKCM | 1 |
| p.V246G | HNSC | 1 |
| p.K193M | LUAD | 1 |
| p.S127Y | COAD | 1 |
| p.P97S | SKCM | 1 |
| p.P146H | LUAD | 1 |
| p.V123M | SKCM | 1 |
| p.G27D | HNSC | 1 |
| p.G26R | LIHC | 1 |
| p.I94M | LUAD | 1 |
| p.A148S | READ | 1 |
| p.P133S | SKCM | 1 |
| p.E79D | COAD | 1 |
| p.S138T | LUAD | 1 |
| p.P178S | LUAD | 1 |
| p.S74L | SARC | 1 |
| p.V232G | HNSC | 1 |
| p.S215A | SKCM | 1 |
| p.N255Y | HNSC | 1 |
| p.V165L | LUAD | 1 |
| p.L203F | SKCM | 1 |
| p.T135N | LUAD | 1 |
| p.E85Q | LUSC | 1 |
| p.Y175H | LUAD | 1 |
| p.C153* | LUAD | 1 |
| p.I78V | HNSC | 1 |
| p.E31D | STAD | 1 |
| p.W57C | LUSC | 1 |
| p.G44C | SKCM | 1 |
| p.P36L | SKCM | 1 |
| p.S67F | SKCM | 1 |
| p.E79K | SKCM | 1 |
| p.D218Y | ESCA | 1 |
| p.P36S | SKCM | 1 |
| p.S156Y | LUAD | 1 |
| p.Y37C | LUAD | 1 |
| p.N98I | SKCM | 1 |
| p.S229A | SKCM | 1 |
| p.A245V | PAAD | 1 |
| p.E32K | SKCM | 1 |
| p.R130S | LUAD | 1 |
| p.L175M | LUAD | 1 |
| p.K207M | LUAD | 1 |
| p.C139* | LUAD | 1 |
| p.A152_splice | UCEC | 1 |
| p.G44D | SKCM | 1 |
| Top |
| TissGeneCNV for PRSS1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for PRSS1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for PRSS1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor) | PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor) | PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor) | PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor) | PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor) | PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor) | PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor) | PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor) | PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor) | PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor) | PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor) | PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor) | PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal) |
 |  |
| Top |
| TissGeneProg for PRSS1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for PRSS1 |
| TissGeneDrug for PRSS1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for PRSS1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0238339 | Hereditary pancreatitis | 107 | BeFree,CLINVAR,UNIPROT |
| umls:C0030305 | Pancreatitis | 78 | BeFree,CTD_human,GAD,GWASCAT,LHGDN,RGD |
| umls:C0149521 | Pancreatitis, Chronic | 76 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0235974 | Pancreatic carcinoma | 15 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 15 | BeFree |
| umls:C0025202 | melanoma | 10 | BeFree |
| umls:C0341471 | Idiopathic chronic pancreatitis | 10 | BeFree |
| umls:C0001339 | Acute pancreatitis | 8 | BeFree |
| umls:C0376670 | Pancreatitis, Alcoholic | 7 | BeFree,GAD |
| umls:C0030297 | Pancreatic Neoplasm | 5 | GAD,LHGDN |
| umls:C0747198 | pancreatitis idiopathic | 5 | BeFree |
| umls:C0010674 | Cystic Fibrosis | 4 | BeFree,RGD |
| umls:C2609129 | Autoimmune pancreatitis | 4 | BeFree |
| umls:C0001418 | Adenocarcinoma | 3 | GAD |
| umls:C0162565 | Acute intermittent porphyria | 3 | BeFree |
| umls:C0267937 | Acute recurrent pancreatitis | 3 | BeFree |
| umls:C0011847 | Diabetes | 2 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 2 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree,RGD |
| umls:C0162835 | Hypopigmentation disorder | 2 | BeFree |
| umls:C0266270 | Pancreas divisum | 2 | BeFree,GAD |
| umls:C0281361 | Adenocarcinoma of pancreas | 2 | BeFree |
| umls:C0677776 | Hereditary Breast and Ovarian Cancer Syndrome | 2 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 2 | BeFree |
| umls:C0699790 | Colon Carcinoma | 2 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 2 | BeFree |
| umls:C0006663 | Calcinosis | 1 | GAD |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 1 | LHGDN |
| umls:C0019196 | Hepatitis C | 1 | BeFree |
| umls:C0020473 | Hyperlipidemia | 1 | GAD |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0030286 | Pancreatic Diseases | 1 | GAD |
| umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0035126 | Reperfusion Injury | 1 | RGD |
| umls:C0036651 | Senile lentigo | 1 | BeFree |
| umls:C0042900 | Vitiligo | 1 | BeFree |
| umls:C0162309 | Adrenoleukodystrophy | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 1 | BeFree |
| umls:C0221002 | Hyperparathyroidism, Primary | 1 | BeFree,GAD |
| umls:C0267963 | Exocrine pancreatic insufficiency | 1 | GAD |
| umls:C0345905 | Intrahepatic Cholangiocarcinoma | 1 | BeFree |
| umls:C0456103 | Sepsis of the newborn | 1 | BeFree |
| umls:C0496836 | Malignant tumor of eye | 1 | BeFree |
| umls:C0522070 | Pancreatic symptom | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C1519680 | Tumor Immunity | 1 | BeFree |
| umls:C1842402 | TROPICAL CALCIFIC PANCREATITIS | 1 | BeFree |
| umls:C1847835 | VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 1 | BeFree |
| umls:C2931038 | Pancreatic carcinoma, familial | 1 | BeFree |
| umls:C3665339 | Bacterial sepsis of newborn | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |