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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PRSS1
check button Gene summary
Basic gene informationGene symbolPRSS1
Gene name
Synonyms
CytomapUCSC genome browser:
Type of gene
RefGenes
Description
Modification date
dbXrefs
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PRSS1
BioGPS: 5645
PathwayNCI Pathway Interaction Database: PRSS1
KEGG: PRSS1
REACTOME: PRSS1
Pathway Commons: PRSS1
ContextiHOP: PRSS1
ligand binding site mutation search in PubMed: PRSS1
UCL Cancer Institute: PRSS1
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Pancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PAAD
Reference showing the relevant tissue of PRSS1
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for PRSS1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH2.749295978-1.2081480223.9574441.77E-066.43E-06
LUSC1.47882139-0.4871413551.9659627451.38E-063.40E-06
THCA2.390480114-0.9546080223.3450881361.76E-142.04E-13
LUAD1.438502323-0.8105718152.2490741383.72E-061.14E-05
PRAD-1.136475330.336453517-1.4729288460.0006660.00224437
COAD0.737618901-0.9901964831.7278153850.0001710.00058909


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TissGene-miRNA for PRSS1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for PRSS1
TissGeneSNV for PRSS1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.Q209EPCPG4
p.I53NKIRC4
p.S229FSKCM3
p.G226RSKCM3
p.G97ESKCM3
p.G83ESKCM2
p.E55KSKCM2
p.V213IUVM2
p.D107NHNSC2
p.D21NSKCM2
p.D121NHNSC2
p.Q173HLUAD2
p.D218YKIRC2
p.E171KSKCM2
p.C30YLUAD2
p.C206SPCPG2
p.A121TLUAD1
p.D20NSKCM1
p.A259VPAAD1
p.N160YSKCM1
p.G226ESKCM1
p.P226LLIHC1
p.P147SSKCM1
p.G212SUCEC1
p.E93DSKCM1
p.G74ESKCM1
p.Q98RESCA1
p.V25APAAD1
p.N160KSARC1
p.S209LLUAD1
p.Y189HLUAD1
p.L224ILUAD1
p.V137MBLCA1
p.Q70LLIHC1
p.G88ESKCM1
p.E157KSKCM1
p.Q38*SKCM1
p.I92VHNSC1
p.S195LLUAD1
p.N29KLUAD1
p.L4FLUSC1
p.A104TPRAD1
p.E85KGBM1
p.E79*CESC1
p.Q98KKIRC1
p.D153NSKCM1
p.G227XESCA1
p.G157SPRAD1
p.A173PLUAD1
p.P3SSKCM1
p.A135TLUAD1
p.P111SSKCM1
p.M1ISKCM1
p.A177TLGG1
p.V179LLUAD1
p.D22NSKCM1
p.R95CLUSC1
p.V123MTHYM1
p.G208VUCEC1
p.S34FSKCM1
p.L14VESCA1
p.F73LCESC1
p.V137MTHYM1
p.Q112RESCA1
p.N77KLUAD1
p.E32KBLCA1
p.G212RSKCM1
p.R68HUCEC1
p.A148ELUAD1
p.N33KSTAD1
p.N84ISKCM1
p.I108MLUAD1
p.E93KSKCM1
p.S129*HNSC1
p.P164SLUAD1
p.S215FSTAD1
p.S215FSKCM1
p.S115*HNSC1
p.H46LLUAD1
p.P17LSKCM1
p.A15VHNSC1
p.N54KLUAD1
p.Q159HLUAD1
p.T149NLUAD1
p.A152TUCEC1
p.P111RLUAD1
p.L189FSKCM1
p.S60LSKCM1
p.A187PLUAD1
p.V137MSKCM1
p.V246GHNSC1
p.K193MLUAD1
p.S127YCOAD1
p.P97SSKCM1
p.P146HLUAD1
p.V123MSKCM1
p.G27DHNSC1
p.G26RLIHC1
p.I94MLUAD1
p.A148SREAD1
p.P133SSKCM1
p.E79DCOAD1
p.S138TLUAD1
p.P178SLUAD1
p.S74LSARC1
p.V232GHNSC1
p.S215ASKCM1
p.N255YHNSC1
p.V165LLUAD1
p.L203FSKCM1
p.T135NLUAD1
p.E85QLUSC1
p.Y175HLUAD1
p.C153*LUAD1
p.I78VHNSC1
p.E31DSTAD1
p.W57CLUSC1
p.G44CSKCM1
p.P36LSKCM1
p.S67FSKCM1
p.E79KSKCM1
p.D218YESCA1
p.P36SSKCM1
p.S156YLUAD1
p.Y37CLUAD1
p.N98ISKCM1
p.S229ASKCM1
p.A245VPAAD1
p.E32KSKCM1
p.R130SLUAD1
p.L175MLUAD1
p.K207MLUAD1
p.C139*LUAD1
p.A152_spliceUCEC1
p.G44DSKCM1


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TissGeneCNV for PRSS1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for PRSS1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for PRSS1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor)PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal)
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COAD (tumor)COAD (normal)
PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor)PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal)
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HNSC (tumor)HNSC (normal)
PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor)PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal)
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KICH (tumor)KICH (normal)
PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor)PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal)
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KIRC (tumor)KIRC (normal)
PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor)PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal)
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KIRP (tumor)KIRP (normal)
PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor)PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal)
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LIHC (tumor)LIHC (normal)
PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor)PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal)
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LUAD (tumor)LUAD (normal)
PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor)PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal)
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LUSC (tumor)LUSC (normal)
PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor)PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal)
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PRAD (tumor)PRAD (normal)
PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor)PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal)
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STAD (tumor)STAD (normal)
PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor)PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal)
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THCA (tumor)THCA (normal)
PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (tumor)PRSS1, GRB2, SERPINA1, SERPINB8, PTPN4, SERPINF2, SERPINB13, TST, SPINK5, DEFA5 (normal)
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TissGeneProg for PRSS1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for PRSS1
TissGeneDrug for PRSS1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for PRSS1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0238339Hereditary pancreatitis107BeFree,CLINVAR,UNIPROT
umls:C0030305Pancreatitis78BeFree,CTD_human,GAD,GWASCAT,LHGDN,RGD
umls:C0149521Pancreatitis, Chronic76BeFree,CTD_human,GAD,LHGDN
umls:C0235974Pancreatic carcinoma15BeFree
umls:C0346647Malignant neoplasm of pancreas15BeFree
umls:C0025202melanoma10BeFree
umls:C0341471Idiopathic chronic pancreatitis10BeFree
umls:C0001339Acute pancreatitis8BeFree
umls:C0376670Pancreatitis, Alcoholic7BeFree,GAD
umls:C0030297Pancreatic Neoplasm5GAD,LHGDN
umls:C0747198pancreatitis idiopathic5BeFree
umls:C0010674Cystic Fibrosis4BeFree,RGD
umls:C2609129Autoimmune pancreatitis4BeFree
umls:C0001418Adenocarcinoma3GAD
umls:C0162565Acute intermittent porphyria3BeFree
umls:C0267937Acute recurrent pancreatitis3BeFree
umls:C0011847Diabetes2BeFree
umls:C0011849Diabetes Mellitus2BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent2BeFree,RGD
umls:C0162835Hypopigmentation disorder2BeFree
umls:C0266270Pancreas divisum2BeFree,GAD
umls:C0281361Adenocarcinoma of pancreas2BeFree
umls:C0677776Hereditary Breast and Ovarian Cancer Syndrome2BeFree
umls:C0677886Epithelial ovarian cancer2BeFree
umls:C0699790Colon Carcinoma2BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma2BeFree
umls:C0006663Calcinosis1GAD
umls:C0007102Malignant tumor of colon1BeFree
umls:C0009375Colonic Neoplasms1BeFree
umls:C0011881Diabetic Nephropathy1LHGDN
umls:C0019196Hepatitis C1BeFree
umls:C0020473Hyperlipidemia1GAD
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0029925Ovarian Carcinoma1BeFree
umls:C0030286Pancreatic Diseases1GAD
umls:C0032580Adenomatous Polyposis Coli1BeFree
umls:C0033578Prostatic Neoplasms1LHGDN
umls:C0035126Reperfusion Injury1RGD
umls:C0036651Senile lentigo1BeFree
umls:C0042900Vitiligo1BeFree
umls:C0162309Adrenoleukodystrophy1BeFree
umls:C0178874Tumor Progression1BeFree
umls:C0206180Ki-1+ Anaplastic Large Cell Lymphoma1BeFree
umls:C0221002Hyperparathyroidism, Primary1BeFree,GAD
umls:C0267963Exocrine pancreatic insufficiency1GAD
umls:C0345905Intrahepatic Cholangiocarcinoma1BeFree
umls:C0456103Sepsis of the newborn1BeFree
umls:C0496836Malignant tumor of eye1BeFree
umls:C0522070Pancreatic symptom1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C1519680Tumor Immunity1BeFree
umls:C1842402TROPICAL CALCIFIC PANCREATITIS1BeFree
umls:C1847835VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)1BeFree
umls:C2931038Pancreatic carcinoma, familial1BeFree
umls:C3665339Bacterial sepsis of newborn1BeFree