TissGeneSummary for PRSS1 |
Gene summary |
Basic gene information | Gene symbol | PRSS1 |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PRSS1 | |
BioGPS: 5645 | ||
Pathway | NCI Pathway Interaction Database: PRSS1 | |
KEGG: PRSS1 | ||
REACTOME: PRSS1 | ||
Pathway Commons: PRSS1 | ||
Context | iHOP: PRSS1 | |
ligand binding site mutation search in PubMed: PRSS1 | ||
UCL Cancer Institute: PRSS1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
Reference showing the relevant tissue of PRSS1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PRSS1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | 2.749295978 | -1.208148022 | 3.957444 | 1.77E-06 | 6.43E-06 |
LUSC | 1.47882139 | -0.487141355 | 1.965962745 | 1.38E-06 | 3.40E-06 |
THCA | 2.390480114 | -0.954608022 | 3.345088136 | 1.76E-14 | 2.04E-13 |
LUAD | 1.438502323 | -0.810571815 | 2.249074138 | 3.72E-06 | 1.14E-05 |
PRAD | -1.13647533 | 0.336453517 | -1.472928846 | 0.000666 | 0.00224437 |
COAD | 0.737618901 | -0.990196483 | 1.727815385 | 0.000171 | 0.00058909 |
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TissGene-miRNA for PRSS1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PRSS1 |
TissGeneSNV for PRSS1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q209E | PCPG | 4 |
p.I53N | KIRC | 4 |
p.S229F | SKCM | 3 |
p.G226R | SKCM | 3 |
p.G97E | SKCM | 3 |
p.G83E | SKCM | 2 |
p.E55K | SKCM | 2 |
p.V213I | UVM | 2 |
p.D107N | HNSC | 2 |
p.D21N | SKCM | 2 |
p.D121N | HNSC | 2 |
p.Q173H | LUAD | 2 |
p.D218Y | KIRC | 2 |
p.E171K | SKCM | 2 |
p.C30Y | LUAD | 2 |
p.C206S | PCPG | 2 |
p.A121T | LUAD | 1 |
p.D20N | SKCM | 1 |
p.A259V | PAAD | 1 |
p.N160Y | SKCM | 1 |
p.G226E | SKCM | 1 |
p.P226L | LIHC | 1 |
p.P147S | SKCM | 1 |
p.G212S | UCEC | 1 |
p.E93D | SKCM | 1 |
p.G74E | SKCM | 1 |
p.Q98R | ESCA | 1 |
p.V25A | PAAD | 1 |
p.N160K | SARC | 1 |
p.S209L | LUAD | 1 |
p.Y189H | LUAD | 1 |
p.L224I | LUAD | 1 |
p.V137M | BLCA | 1 |
p.Q70L | LIHC | 1 |
p.G88E | SKCM | 1 |
p.E157K | SKCM | 1 |
p.Q38* | SKCM | 1 |
p.I92V | HNSC | 1 |
p.S195L | LUAD | 1 |
p.N29K | LUAD | 1 |
p.L4F | LUSC | 1 |
p.A104T | PRAD | 1 |
p.E85K | GBM | 1 |
p.E79* | CESC | 1 |
p.Q98K | KIRC | 1 |
p.D153N | SKCM | 1 |
p.G227X | ESCA | 1 |
p.G157S | PRAD | 1 |
p.A173P | LUAD | 1 |
p.P3S | SKCM | 1 |
p.A135T | LUAD | 1 |
p.P111S | SKCM | 1 |
p.M1I | SKCM | 1 |
p.A177T | LGG | 1 |
p.V179L | LUAD | 1 |
p.D22N | SKCM | 1 |
p.R95C | LUSC | 1 |
p.V123M | THYM | 1 |
p.G208V | UCEC | 1 |
p.S34F | SKCM | 1 |
p.L14V | ESCA | 1 |
p.F73L | CESC | 1 |
p.V137M | THYM | 1 |
p.Q112R | ESCA | 1 |
p.N77K | LUAD | 1 |
p.E32K | BLCA | 1 |
p.G212R | SKCM | 1 |
p.R68H | UCEC | 1 |
p.A148E | LUAD | 1 |
p.N33K | STAD | 1 |
p.N84I | SKCM | 1 |
p.I108M | LUAD | 1 |
p.E93K | SKCM | 1 |
p.S129* | HNSC | 1 |
p.P164S | LUAD | 1 |
p.S215F | STAD | 1 |
p.S215F | SKCM | 1 |
p.S115* | HNSC | 1 |
p.H46L | LUAD | 1 |
p.P17L | SKCM | 1 |
p.A15V | HNSC | 1 |
p.N54K | LUAD | 1 |
p.Q159H | LUAD | 1 |
p.T149N | LUAD | 1 |
p.A152T | UCEC | 1 |
p.P111R | LUAD | 1 |
p.L189F | SKCM | 1 |
p.S60L | SKCM | 1 |
p.A187P | LUAD | 1 |
p.V137M | SKCM | 1 |
p.V246G | HNSC | 1 |
p.K193M | LUAD | 1 |
p.S127Y | COAD | 1 |
p.P97S | SKCM | 1 |
p.P146H | LUAD | 1 |
p.V123M | SKCM | 1 |
p.G27D | HNSC | 1 |
p.G26R | LIHC | 1 |
p.I94M | LUAD | 1 |
p.A148S | READ | 1 |
p.P133S | SKCM | 1 |
p.E79D | COAD | 1 |
p.S138T | LUAD | 1 |
p.P178S | LUAD | 1 |
p.S74L | SARC | 1 |
p.V232G | HNSC | 1 |
p.S215A | SKCM | 1 |
p.N255Y | HNSC | 1 |
p.V165L | LUAD | 1 |
p.L203F | SKCM | 1 |
p.T135N | LUAD | 1 |
p.E85Q | LUSC | 1 |
p.Y175H | LUAD | 1 |
p.C153* | LUAD | 1 |
p.I78V | HNSC | 1 |
p.E31D | STAD | 1 |
p.W57C | LUSC | 1 |
p.G44C | SKCM | 1 |
p.P36L | SKCM | 1 |
p.S67F | SKCM | 1 |
p.E79K | SKCM | 1 |
p.D218Y | ESCA | 1 |
p.P36S | SKCM | 1 |
p.S156Y | LUAD | 1 |
p.Y37C | LUAD | 1 |
p.N98I | SKCM | 1 |
p.S229A | SKCM | 1 |
p.A245V | PAAD | 1 |
p.E32K | SKCM | 1 |
p.R130S | LUAD | 1 |
p.L175M | LUAD | 1 |
p.K207M | LUAD | 1 |
p.C139* | LUAD | 1 |
p.A152_splice | UCEC | 1 |
p.G44D | SKCM | 1 |
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TissGeneCNV for PRSS1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PRSS1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for PRSS1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PRSS1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PRSS1 |
TissGeneDrug for PRSS1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PRSS1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0238339 | Hereditary pancreatitis | 107 | BeFree,CLINVAR,UNIPROT |
umls:C0030305 | Pancreatitis | 78 | BeFree,CTD_human,GAD,GWASCAT,LHGDN,RGD |
umls:C0149521 | Pancreatitis, Chronic | 76 | BeFree,CTD_human,GAD,LHGDN |
umls:C0235974 | Pancreatic carcinoma | 15 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 15 | BeFree |
umls:C0025202 | melanoma | 10 | BeFree |
umls:C0341471 | Idiopathic chronic pancreatitis | 10 | BeFree |
umls:C0001339 | Acute pancreatitis | 8 | BeFree |
umls:C0376670 | Pancreatitis, Alcoholic | 7 | BeFree,GAD |
umls:C0030297 | Pancreatic Neoplasm | 5 | GAD,LHGDN |
umls:C0747198 | pancreatitis idiopathic | 5 | BeFree |
umls:C0010674 | Cystic Fibrosis | 4 | BeFree,RGD |
umls:C2609129 | Autoimmune pancreatitis | 4 | BeFree |
umls:C0001418 | Adenocarcinoma | 3 | GAD |
umls:C0162565 | Acute intermittent porphyria | 3 | BeFree |
umls:C0267937 | Acute recurrent pancreatitis | 3 | BeFree |
umls:C0011847 | Diabetes | 2 | BeFree |
umls:C0011849 | Diabetes Mellitus | 2 | BeFree |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree,RGD |
umls:C0162835 | Hypopigmentation disorder | 2 | BeFree |
umls:C0266270 | Pancreas divisum | 2 | BeFree,GAD |
umls:C0281361 | Adenocarcinoma of pancreas | 2 | BeFree |
umls:C0677776 | Hereditary Breast and Ovarian Cancer Syndrome | 2 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 2 | BeFree |
umls:C0699790 | Colon Carcinoma | 2 | BeFree |
umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 2 | BeFree |
umls:C0006663 | Calcinosis | 1 | GAD |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0009375 | Colonic Neoplasms | 1 | BeFree |
umls:C0011881 | Diabetic Nephropathy | 1 | LHGDN |
umls:C0019196 | Hepatitis C | 1 | BeFree |
umls:C0020473 | Hyperlipidemia | 1 | GAD |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0030286 | Pancreatic Diseases | 1 | GAD |
umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
umls:C0035126 | Reperfusion Injury | 1 | RGD |
umls:C0036651 | Senile lentigo | 1 | BeFree |
umls:C0042900 | Vitiligo | 1 | BeFree |
umls:C0162309 | Adrenoleukodystrophy | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 1 | BeFree |
umls:C0221002 | Hyperparathyroidism, Primary | 1 | BeFree,GAD |
umls:C0267963 | Exocrine pancreatic insufficiency | 1 | GAD |
umls:C0345905 | Intrahepatic Cholangiocarcinoma | 1 | BeFree |
umls:C0456103 | Sepsis of the newborn | 1 | BeFree |
umls:C0496836 | Malignant tumor of eye | 1 | BeFree |
umls:C0522070 | Pancreatic symptom | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
umls:C1519680 | Tumor Immunity | 1 | BeFree |
umls:C1842402 | TROPICAL CALCIFIC PANCREATITIS | 1 | BeFree |
umls:C1847835 | VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 1 | BeFree |
umls:C2931038 | Pancreatic carcinoma, familial | 1 | BeFree |
umls:C3665339 | Bacterial sepsis of newborn | 1 | BeFree |