TissGeneSummary for KLK7 |
Gene summary |
Basic gene information | Gene symbol | KLK7 |
Gene name | kallikrein-related peptidase 7 | |
Synonyms | PRSS6|SCCE|hK7 | |
Cytomap | UCSC genome browser: 19q13.41 | |
Type of gene | protein-coding | |
RefGenes | NM_001243126.1, NM_001207053.1,NM_005046.3,NM_139277.2, | |
Description | kallikrein 7 (chymotryptic, stratum corneum)kallikrein-7serine protease 6signal proteinstratum corneum chymotryptic enzyme | |
Modification date | 20141207 | |
dbXrefs | MIM : 604438 | |
HGNC : HGNC | ||
Ensembl : ENSG00000169035 | ||
HPRD : 05115 | ||
Vega : OTTHUMG00000182917 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KLK7 | |
BioGPS: 5650 | ||
Pathway | NCI Pathway Interaction Database: KLK7 | |
KEGG: KLK7 | ||
REACTOME: KLK7 | ||
Pathway Commons: KLK7 | ||
Context | iHOP: KLK7 | |
ligand binding site mutation search in PubMed: KLK7 | ||
UCL Cancer Institute: KLK7 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvarySkin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVSKCM | |
Reference showing the relevant tissue of KLK7 | ||
Description by TissGene annotations | Risk TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KLK7 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | 0.966082828 | 4.034206512 | -3.068123684 | 1.45E-14 | 7.33E-14 |
KIRP | -2.542188938 | 2.676676687 | -5.218865625 | 2.52E-11 | 3.21E-10 |
COAD | 1.00248438 | -3.495877159 | 4.498361538 | 3.92E-07 | 2.41E-06 |
KIRC | -2.986360813 | 1.897625299 | -4.883986111 | 1.91E-18 | 1.30E-17 |
THCA | 4.019587704 | -1.109415685 | 5.12900339 | 7.20E-16 | 1.11E-14 |
KICH | -3.344457313 | 1.371982687 | -4.71644 | 2.57E-07 | 1.08E-06 |
HNSC | 5.726831339 | 7.159738315 | -1.432906977 | 0.01 | 0.024779736 |
LUAD | -0.301675037 | 1.863723239 | -2.165398276 | 4.19E-05 | 0.000112688 |
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TissGene-miRNA for KLK7 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KLK7 |
TissGeneSNV for KLK7 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P140S | SKCM | 2 |
p.G222E | SKCM | 2 |
p.D175Y | LUAD | 1 |
p.L113I | UCEC | 1 |
p.C226Y | LUAD | 1 |
p.Q107K | LUAD | 1 |
p.R136H | THYM | 1 |
p.P225L | SKCM | 1 |
p.G56* | UCEC | 1 |
p.P225S | SKCM | 1 |
p.S187A | READ | 1 |
p.R100C | SKCM | 1 |
p.Q216* | LAML | 1 |
p.G207R | LUAD | 1 |
p.H43N | ACC | 1 |
p.T84M | BRCA | 1 |
p.M249I | SKCM | 1 |
p.C239Y | LUSC | 1 |
p.A122V | PAAD | 1 |
p.H54Y | LIHC | 1 |
p.S187F | SKCM | 1 |
p.R212S | ACC | 1 |
p.A56G | KIRP | 1 |
p.V157L | LUAD | 1 |
p.Q174H | UCEC | 1 |
p.L6V | SKCM | 1 |
p.S59R | KIRP | 1 |
p.G141E | STAD | 1 |
p.P102A | LUAD | 1 |
p.A50D | LIHC | 1 |
p.S96L | SKCM | 1 |
p.S126F | UCEC | 1 |
p.G33D | UCEC | 1 |
p.P102H | LUAD | 1 |
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TissGeneCNV for KLK7 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KLK7 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-44-A4SU-01A | KDM4C-KLK7 | In-frame | Chr9:7049200 | Chr19:51480947 |
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TissGeneNet for KLK7 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KLK7 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KLK7 |
TissGeneDrug for KLK7 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KLK7 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0029925 | Ovarian Carcinoma | 7 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 7 | BeFree |
umls:C0013595 | Eczema | 5 | BeFree,GAD |
umls:C0596263 | Carcinogenesis | 4 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 4 | BeFree |
umls:C0919267 | ovarian neoplasm | 4 | BeFree,LHGDN |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
umls:C0011615 | Dermatitis, Atopic | 3 | BeFree,GAD,LHGDN |
umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
umls:C0033860 | Psoriasis | 3 | BeFree |
umls:C0265962 | Ichthyosis linearis circumflexa | 3 | BeFree |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C0699790 | Colon Carcinoma | 3 | BeFree |
umls:C0001418 | Adenocarcinoma | 2 | BeFree |
umls:C0001430 | Adenoma | 2 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
umls:C0033774 | Pruritus | 2 | BeFree |
umls:C0037274 | Dermatologic disorders | 2 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree,GAD |
umls:C1527249 | Colorectal Cancer | 2 | BeFree |
umls:C2985318 | Pregnancy Related Skin Change | 2 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
umls:C0009375 | Colonic Neoplasms | 1 | BeFree |
umls:C0011603 | Dermatitis | 1 | BeFree |
umls:C0030297 | Pancreatic Neoplasm | 1 | LHGDN |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0279628 | Adenocarcinoma Of Esophagus | 1 | BeFree |
umls:C0338106 | Adenocarcinoma of colon | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0477474 | Dermatitis and eczema | 1 | GAD |
umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
umls:C0497327 | Dementia | 1 | LHGDN |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
umls:C0949541 | Hurthle Cell Tumor | 1 | BeFree |
umls:C1378050 | Oncocytic Neoplasm | 1 | BeFree |
umls:C1510502 | Oxyphilic Adenoma | 1 | BeFree |
umls:C1559271 | Non-Malignant Ascites Adverse Event | 1 | BeFree |
umls:C1836607 | MYOTILINOPATHY | 1 | BeFree |
umls:C2931852 | Clear-cell metastatic renal cell carcinoma | 1 | BeFree |