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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for KLK7
check button Gene summary
Basic gene informationGene symbolKLK7
Gene namekallikrein-related peptidase 7
SynonymsPRSS6|SCCE|hK7
CytomapUCSC genome browser: 19q13.41
Type of geneprotein-coding
RefGenesNM_001243126.1,
NM_001207053.1,NM_005046.3,NM_139277.2,
Descriptionkallikrein 7 (chymotryptic, stratum corneum)kallikrein-7serine protease 6signal proteinstratum corneum chymotryptic enzyme
Modification date20141207
dbXrefs MIM : 604438
HGNC : HGNC
Ensembl : ENSG00000169035
HPRD : 05115
Vega : OTTHUMG00000182917
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KLK7
BioGPS: 5650
PathwayNCI Pathway Interaction Database: KLK7
KEGG: KLK7
REACTOME: KLK7
Pathway Commons: KLK7
ContextiHOP: KLK7
ligand binding site mutation search in PubMed: KLK7
UCL Cancer Institute: KLK7
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)OvarySkin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)OVSKCM
Reference showing the relevant tissue of KLK7
Description by TissGene annotationsRisk TissGene in RFS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for KLK7

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BRCA0.9660828284.034206512-3.0681236841.45E-147.33E-14
KIRP-2.5421889382.676676687-5.2188656252.52E-113.21E-10
COAD1.00248438-3.4958771594.4983615383.92E-072.41E-06
KIRC-2.9863608131.897625299-4.8839861111.91E-181.30E-17
THCA4.019587704-1.1094156855.129003397.20E-161.11E-14
KICH-3.3444573131.371982687-4.716442.57E-071.08E-06
HNSC5.7268313397.159738315-1.4329069770.010.024779736
LUAD-0.3016750371.863723239-2.1653982764.19E-050.000112688


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TissGene-miRNA for KLK7

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for KLK7
TissGeneSNV for KLK7

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.P140SSKCM2
p.G222ESKCM2
p.D175YLUAD1
p.L113IUCEC1
p.C226YLUAD1
p.Q107KLUAD1
p.R136HTHYM1
p.P225LSKCM1
p.G56*UCEC1
p.P225SSKCM1
p.S187AREAD1
p.R100CSKCM1
p.Q216*LAML1
p.G207RLUAD1
p.H43NACC1
p.T84MBRCA1
p.M249ISKCM1
p.C239YLUSC1
p.A122VPAAD1
p.H54YLIHC1
p.S187FSKCM1
p.R212SACC1
p.A56GKIRP1
p.V157LLUAD1
p.Q174HUCEC1
p.L6VSKCM1
p.S59RKIRP1
p.G141ESTAD1
p.P102ALUAD1
p.A50DLIHC1
p.S96LSKCM1
p.S126FUCEC1
p.G33DUCEC1
p.P102HLUAD1


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TissGeneCNV for KLK7

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for KLK7

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
TCGAfusionPortalPRADALUADTCGA-44-A4SU-01AKDM4C-KLK7In-frameChr9:7049200Chr19:51480947


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TissGeneNet for KLK7

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
KLK7, UBC, CDSN (tumor)KLK7, UBC, CDSN (normal)
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COAD (tumor)COAD (normal)
KLK7, UBC, CDSN (tumor)KLK7, UBC, CDSN (normal)
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HNSC (tumor)HNSC (normal)
KLK7, UBC, CDSN (tumor)KLK7, UBC, CDSN (normal)
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KICH (tumor)KICH (normal)
KLK7, UBC, CDSN (tumor)KLK7, UBC, CDSN (normal)
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KIRC (tumor)KIRC (normal)
KLK7, UBC, CDSN (tumor)KLK7, UBC, CDSN (normal)
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KIRP (tumor)KIRP (normal)
KLK7, UBC, CDSN (tumor)KLK7, UBC, CDSN (normal)
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LIHC (tumor)LIHC (normal)
KLK7, UBC, CDSN (tumor)KLK7, UBC, CDSN (normal)
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LUAD (tumor)LUAD (normal)
KLK7, UBC, CDSN (tumor)KLK7, UBC, CDSN (normal)
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LUSC (tumor)LUSC (normal)
KLK7, UBC, CDSN (tumor)KLK7, UBC, CDSN (normal)
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PRAD (tumor)PRAD (normal)
KLK7, UBC, CDSN (tumor)KLK7, UBC, CDSN (normal)
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STAD (tumor)STAD (normal)
KLK7, UBC, CDSN (tumor)KLK7, UBC, CDSN (normal)
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THCA (tumor)THCA (normal)
KLK7, UBC, CDSN (tumor)KLK7, UBC, CDSN (normal)
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TissGeneProg for KLK7

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for KLK7
TissGeneDrug for KLK7

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for KLK7

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0029925Ovarian Carcinoma7BeFree
umls:C1140680Malignant neoplasm of ovary7BeFree
umls:C0013595Eczema5BeFree,GAD
umls:C0596263Carcinogenesis4BeFree
umls:C0677886Epithelial ovarian cancer4BeFree
umls:C0919267ovarian neoplasm4BeFree,LHGDN
umls:C0006142Malignant neoplasm of breast3BeFree
umls:C0007102Malignant tumor of colon3BeFree
umls:C0011615Dermatitis, Atopic3BeFree,GAD,LHGDN
umls:C0027627Neoplasm Metastasis3BeFree
umls:C0033860Psoriasis3BeFree
umls:C0265962Ichthyosis linearis circumflexa3BeFree
umls:C0678222Breast Carcinoma3BeFree
umls:C0699790Colon Carcinoma3BeFree
umls:C0001418Adenocarcinoma2BeFree
umls:C0001430Adenoma2BeFree
umls:C0009402Colorectal Carcinoma2BeFree
umls:C0033774Pruritus2BeFree
umls:C0037274Dermatologic disorders2BeFree
umls:C0376358Malignant neoplasm of prostate2BeFree,GAD
umls:C1527249Colorectal Cancer2BeFree
umls:C2985318Pregnancy Related Skin Change2BeFree
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0009375Colonic Neoplasms1BeFree
umls:C0011603Dermatitis1BeFree
umls:C0030297Pancreatic Neoplasm1LHGDN
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0279628Adenocarcinoma Of Esophagus1BeFree
umls:C0338106Adenocarcinoma of colon1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0477474Dermatitis and eczema1GAD
umls:C0494165Secondary malignant neoplasm of liver1BeFree
umls:C0497327Dementia1LHGDN
umls:C0600139Prostate carcinoma1BeFree
umls:C0686619Secondary malignant neoplasm of lymph node1BeFree
umls:C0949541Hurthle Cell Tumor1BeFree
umls:C1378050Oncocytic Neoplasm1BeFree
umls:C1510502Oxyphilic Adenoma1BeFree
umls:C1559271Non-Malignant Ascites Adverse Event1BeFree
umls:C1836607MYOTILINOPATHY1BeFree
umls:C2931852Clear-cell metastatic renal cell carcinoma1BeFree