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| TissGeneSummary for CHST7 |
 Gene summary |
| Basic gene information | Gene symbol | CHST7 |
| Gene name | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 | |
| Synonyms | C6ST-2|GST-5 | |
| Cytomap | UCSC genome browser: Xp11.23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_019886.3, | |
| Description | N-acetylglucosamine 6-O-sulfotransferase 4carbohydrate sulfotransferase 7chondroitin 6-sulfotransferase-2galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5glcNAc6ST-4gn6st-4 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300375 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000147119 | ||
| HPRD : 02302 | ||
| Vega : OTTHUMG00000021423 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CHST7 | |
| BioGPS: 56548 | ||
| Pathway | NCI Pathway Interaction Database: CHST7 | |
| KEGG: CHST7 | ||
| REACTOME: CHST7 | ||
| Pathway Commons: CHST7 | ||
| Context | iHOP: CHST7 | |
| ligand binding site mutation search in PubMed: CHST7 | ||
| UCL Cancer Institute: CHST7 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryPancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVPAAD | |
| Reference showing the relevant tissue of CHST7 | ||
| Description by TissGene annotations | Protective TissGene in OS Cancer gene Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006044 | N-acetylglucosamine metabolic process | 10913333 | GO:0006790 | sulfur compound metabolic process | 10913333 | GO:0030206 | chondroitin sulfate biosynthetic process | 10781596 | GO:0006044 | N-acetylglucosamine metabolic process | 10913333 | GO:0006790 | sulfur compound metabolic process | 10913333 | GO:0030206 | chondroitin sulfate biosynthetic process | 10781596 |
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| TissGeneExp for CHST7 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -1.437417362 | -0.15103052 | -1.286386842 | 3.20E-33 | 5.15E-32 |
| LIHC | -0.079332099 | 1.384607901 | -1.46394 | 1.53E-09 | 1.60E-08 |
| HNSC | 0.413509994 | -1.325878378 | 1.739388372 | 1.13E-08 | 1.36E-07 |
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| TissGene-miRNA for CHST7 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-328-3p | MIMAT0000752 | 0.024 | -0.26 | 78 |
| ACC | hsa-miR-328-3p | MIMAT0000752 | 0.024 | -0.26 | 78 |
| KICH | hsa-miR-20a-5p | MIMAT0000075 | 0.0053 | -0.3 | 89 |
| KICH | hsa-miR-20a-5p | MIMAT0000075 | 0.0053 | -0.3 | 89 |
| KICH | hsa-miR-20a-5p | MIMAT0000075 | 0.0053 | -0.3 | 89 |
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| TissGeneMut for CHST7 |
| TissGeneSNV for CHST7 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V232M | UCEC | 1 |
| p.E147D | UCEC | 1 |
| p.R265H | STAD | 1 |
| p.G113D | KIRC | 1 |
| p.D145N | BLCA | 1 |
| p.G94W | LIHC | 1 |
| p.R242Q | UCEC | 1 |
| p.T184M | STAD | 1 |
| p.R461C | SKCM | 1 |
| p.R169Q | SKCM | 1 |
| p.P174L | BLCA | 1 |
| p.A60V | ESCA | 1 |
| p.R235C | STAD | 1 |
| p.L160V | LUAD | 1 |
| p.E350K | HNSC | 1 |
| p.A181T | LIHC | 1 |
| p.D176E | STAD | 1 |
| p.M408L | KIRP | 1 |
| p.A185T | STAD | 1 |
| p.Q150L | SKCM | 1 |
| p.P143L | UCEC | 1 |
| p.R99H | STAD | 1 |
| p.R455H | STAD | 1 |
| p.A178V | KIRP | 1 |
| p.F193L | LUAD | 1 |
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| TissGeneCNV for CHST7 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CHST7 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CHST7 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for CHST7 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CHST7 |
| TissGeneDrug for CHST7 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CHST7 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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