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| TissGeneSummary for KLK10 |
 Gene summary |
| Basic gene information | Gene symbol | KLK10 |
| Gene name | kallikrein-related peptidase 10 | |
| Synonyms | NES1|PRSSL1 | |
| Cytomap | UCSC genome browser: 19q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001077500.1, NM_002776.4,NM_145888.2, | |
| Description | breast normal epithelial cell associated serine proteasekallikrein 10 protein 1kallikrein 10 protein 12kallikrein 10 protein 2kallikrein 10 protein 3kallikrein 10 protein 4kallikrein 10 protein 7kallikrein 10 protein 8kallikrein 10 protein 9kalli | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602673 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000129451 | ||
| HPRD : 04054 | ||
| Vega : OTTHUMG00000182916 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KLK10 | |
| BioGPS: 5655 | ||
| Pathway | NCI Pathway Interaction Database: KLK10 | |
| KEGG: KLK10 | ||
| REACTOME: KLK10 | ||
| Pathway Commons: KLK10 | ||
| Context | iHOP: KLK10 | |
| ligand binding site mutation search in PubMed: KLK10 | ||
| UCL Cancer Institute: KLK10 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusOvary | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCAOV | |
| Reference showing the relevant tissue of KLK10 | ||
| Description by TissGene annotations | Cancer gene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for KLK10 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -4.130177697 | -2.845295752 | -1.284881944 | 4.01E-06 | 9.73E-06 |
| BRCA | -0.270324553 | 2.117432464 | -2.387757018 | 2.43E-10 | 9.24E-10 |
| LIHC | -3.841309641 | -1.728747641 | -2.112562 | 1.17E-07 | 8.10E-07 |
| THCA | 4.150525105 | -1.331220658 | 5.481745763 | 1.46E-18 | 3.99E-17 |
| LUAD | 0.757483462 | 3.623376566 | -2.865893103 | 6.46E-10 | 3.49E-09 |
| COAD | 3.547401897 | -0.567275026 | 4.114676923 | 2.85E-07 | 1.83E-06 |
| STAD | 3.607240359 | 1.637477859 | 1.9697625 | 0.0162 | 0.04984104 |
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| TissGene-miRNA for KLK10 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KLK10 |
| TissGeneSNV for KLK10 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S50A | COAD | 4 |
| p.L243F | SKCM | 2 |
| p.R274H | UCEC | 1 |
| p.W268X | STAD | 1 |
| p.R220Q | KIRC | 1 |
| p.I269V | UCEC | 1 |
| p.R114H | UCEC | 1 |
| p.S12C | LUAD | 1 |
| p.Q57* | BLCA | 1 |
| p.R274S | TGCT | 1 |
| p.T260S | LUAD | 1 |
| p.P206T | THYM | 1 |
| p.M213I | BLCA | 1 |
| p.S77N | UCEC | 1 |
| p.M1I | BLCA | 1 |
| p.C87S | LIHC | 1 |
| p.W268* | STAD | 1 |
| p.A120T | UCEC | 1 |
| p.W245C | LUAD | 1 |
| p.P256L | BLCA | 1 |
| p.A179D | THYM | 1 |
| p.P58S | STAD | 1 |
| p.G251S | SKCM | 1 |
| p.A85T | LIHC | 1 |
| p.D228N | BRCA | 1 |
| p.P256L | SKCM | 1 |
| p.P249L | SKCM | 1 |
| p.V117F | UCEC | 1 |
| p.R274C | THYM | 1 |
| p.W268R | ESCA | 1 |
| p.G66C | LIHC | 1 |
| p.S252Y | ESCA | 1 |
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| TissGeneCNV for KLK10 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KLK10 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW999510 | KLK10-ZSCAN29 | chr19:51518756 | chr15:43651374 | |
| Chimerdb3.0 | ChiTaRs | NA | BM981978 | KLK10-KLK10 | chr19:51517831 | chr19:51517852 |
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| TissGeneNet for KLK10 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KLK10, RIF1, BCAP31 (tumor) | KLK10, RIF1, BCAP31 (normal) |
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| COAD (tumor) | COAD (normal) |
| KLK10, RIF1, BCAP31 (tumor) | KLK10, RIF1, BCAP31 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KLK10, RIF1, BCAP31 (tumor) | KLK10, RIF1, BCAP31 (normal) |
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| KICH (tumor) | KICH (normal) |
| KLK10, RIF1, BCAP31 (tumor) | KLK10, RIF1, BCAP31 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KLK10, RIF1, BCAP31 (tumor) | KLK10, RIF1, BCAP31 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KLK10, RIF1, BCAP31 (tumor) | KLK10, RIF1, BCAP31 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| KLK10, RIF1, BCAP31 (tumor) | KLK10, RIF1, BCAP31 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| KLK10, RIF1, BCAP31 (tumor) | KLK10, RIF1, BCAP31 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| KLK10, RIF1, BCAP31 (tumor) | KLK10, RIF1, BCAP31 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KLK10, RIF1, BCAP31 (tumor) | KLK10, RIF1, BCAP31 (normal) |
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| STAD (tumor) | STAD (normal) |
| KLK10, RIF1, BCAP31 (tumor) | KLK10, RIF1, BCAP31 (normal) |
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| THCA (tumor) | THCA (normal) |
| KLK10, RIF1, BCAP31 (tumor) | KLK10, RIF1, BCAP31 (normal) |
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| TissGeneProg for KLK10 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KLK10 |
| TissGeneDrug for KLK10 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KLK10 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 15 | BeFree |
| umls:C0678222 | Breast Carcinoma | 13 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 9 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 6 | BeFree,GAD |
| umls:C1458155 | Mammary Neoplasms | 6 | BeFree,CTD_human,LHGDN |
| umls:C0024623 | Malignant neoplasm of stomach | 5 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 4 | BeFree,GAD |
| umls:C0699791 | Stomach Carcinoma | 4 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 3 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 3 | BeFree,GAD |
| umls:C0919267 | ovarian neoplasm | 3 | BeFree,CTD_human,LHGDN |
| umls:C1527249 | Colorectal Cancer | 3 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0000786 | Spontaneous abortion | 1 | CTD_human |
| umls:C0001418 | Adenocarcinoma | 1 | LHGDN |
| umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 1 | BeFree |
| umls:C0007133 | Carcinoma, Papillary | 1 | LHGDN |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0014070 | Encephalomyelitis | 1 | BeFree |
| umls:C0019163 | Hepatitis B | 1 | BeFree |
| umls:C0022680 | Polycystic Kidney Diseases | 1 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 1 | BeFree |
| umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
| umls:C0033860 | Psoriasis | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | CTD_human,LHGDN |
| umls:C0206650 | Fibroadenoma | 1 | BeFree |
| umls:C0497327 | Dementia | 1 | LHGDN |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0677898 | invasive cancer | 1 | BeFree |
| umls:C0685938 | Malignant neoplasm of gastrointestinal tract | 1 | BeFree |
| umls:C0848576 | female breast hyperplasia | 1 | BeFree |
| umls:C0948303 | Carcinoma of peritoneum | 1 | BeFree |
| umls:C1134719 | Invasive Ductal Breast Carcinoma | 1 | BeFree |
| umls:C1334206 | Intermediate Grade Ductal Breast Carcinoma In Situ | 1 | BeFree |
| umls:C1334274 | Invasive Carcinoma | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
| umls:C1514428 | Primary Peritoneal Carcinoma | 1 | BeFree |
| umls:C1559271 | Non-Malignant Ascites Adverse Event | 1 | BeFree |
| umls:C1623038 | Cirrhosis | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2986665 | Early-Stage Breast Carcinoma | 1 | BeFree |
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