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| TissGeneSummary for PSMA4 |
 Gene summary |
| Basic gene information | Gene symbol | PSMA4 |
| Gene name | proteasome (prosome, macropain) subunit, alpha type, 4 | |
| Synonyms | HC9|HsT17706|PSC9 | |
| Cytomap | UCSC genome browser: 15q25.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001102667.1, NM_001102668.1,NM_002789.4, | |
| Description | macropain subunit C9multicatalytic endopeptidase complex subunit C9proteasome component C9proteasome subunit HC9proteasome subunit Lproteasome subunit alpha type-4 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 176846 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000041357 | ||
| HPRD : 10168 | ||
| Vega : OTTHUMG00000143859 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PSMA4 | |
| BioGPS: 5685 | ||
| Pathway | NCI Pathway Interaction Database: PSMA4 | |
| KEGG: PSMA4 | ||
| REACTOME: PSMA4 | ||
| Pathway Commons: PSMA4 | ||
| Context | iHOP: PSMA4 | |
| ligand binding site mutation search in PubMed: PSMA4 | ||
| UCL Cancer Institute: PSMA4 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderBone marrowTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCALAMLTGCT | |
| Reference showing the relevant tissue of PSMA4 | ||
| Description by TissGene annotations | Protective TissGene in RFS TissgsLTS Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PSMA4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for PSMA4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-146b-5p | MIMAT0002809 | 0.021 | -0.27 | 78 |
| ACC | hsa-miR-146b-5p | MIMAT0002809 | 0.021 | -0.27 | 78 |
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| TissGeneMut for PSMA4 |
| TissGeneSNV for PSMA4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A39V | LGG | 1 |
| p.R249H | UCEC | 1 |
| p.Q119L | LIHC | 1 |
| p.T122I | ESCA | 1 |
| p.R50S | KIRC | 1 |
| p.E182X | COAD | 1 |
| p.Q114E | BLCA | 1 |
| p.Q164L | SKCM | 1 |
| p.G131C | LUSC | 1 |
| p.I105M | STAD | 1 |
| p.P129L | SKCM | 1 |
| p.I194S | KIRC | 1 |
| p.A113V | UCEC | 1 |
| p.E182G | SKCM | 1 |
| p.K229E | STAD | 1 |
| p.A169S | LUAD | 1 |
| p.D116N | LIHC | 1 |
| p.R57H | THCA | 1 |
| p.P58L | SKCM | 1 |
| p.Q119H | UCS | 1 |
| p.E250K | BLCA | 1 |
| p.Q235L | SKCM | 1 |
| p.L56F | SKCM | 1 |
| p.E15K | BLCA | 1 |
| p.G36R | SKCM | 1 |
| p.E253G | SKCM | 1 |
| p.I79L | LUAD | 1 |
| p.R128H | THCA | 1 |
| p.W139* | PRAD | 1 |
| p.V59A | STAD | 1 |
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| TissGeneCNV for PSMA4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PSMA4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BU190440 | PSMA4-PSAP | chr15:78841523 | chr10:73578373 | |
| Chimerdb3.0 | ChiTaRs | NA | AW149658 | RAB31-PSMA4 | chr18:9862549 | chr15:78841164 | |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A0AZ-01A | RSF1-PSMA4 | In-Frame | chr11:77451775 | chr15:78837210 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-A1-A0SO-01A | IREB2-PSMA4 | In-Frame | chr15:78758831 | chr15:78836531 |
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| TissGeneNet for PSMA4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PSMA4, TRAF6, SUMO2, PSMB4, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, SIRT1, PSMA7, PSMA3, NEDD8, PSMB9, PSMG1, PSMB5, PSMB6, PSMG2, C2, PSMA5 (tumor) | PSMA4, SUMO2, KIAA0101, PSMB4, PLK1, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, PSMA7, PSMA3, PSMB9, PSMG1, PSMB5, PSMB6, PSMG2, PSMB8, PSMA5, PSMG3 (normal) |
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| COAD (tumor) | COAD (normal) |
| PSMA4, SUMO2, PSMB4, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, UCHL5, PSMA7, PSMA3, NEDD8, PSMB9, PSMG1, PSMB5, PSMB6, PSMG2, PSMB8, PSMA5, PSMG3 (tumor) | PSMA4, TRAF6, SUMO2, KIAA0101, PSMB4, PSMA1, PSMB1, PSMA6, PARK2, PSMA2, PSMB7, PSMA3, NEDD8, RPS27A, PSMG1, PSMB5, PSMB6, PSMG2, PSMB8, PSMA5, PSMG3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PSMA4, SUMO2, KIAA0101, PSMB4, PSMA1, POMP, E2F4, PSMB1, PSMA6, PSMA2, PSMB7, SIRT1, PSMA7, PSMA3, NEDD8, PSMG1, PSMB6, PSMG2, BHLHE41, PSMA5, PSMG3 (tumor) | PSMA4, SUMO2, KIAA0101, PSMB4, SIRT3, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, SIRT1, PSMA7, PSMA3, NEDD8, RPS27A, PSMG1, PSMB6, PSMB8, PSMA5, PSMG3 (normal) |
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| KICH (tumor) | KICH (normal) |
| PSMA4, PSMB4, NFKB1, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, PSMA7, PSMA3, NEDD8, RPS27A, SIRT2, PSMG1, PSMB5, PSMB6, PSMG2, PSMB8, PSMA5, PSMG3 (tumor) | PSMA4, CSNK2A1, TRAF6, SUMO2, PSMB4, FKBP8, POMP, PSMB1, PSMA6, PSMB7, PSMA7, PSMA3, NEDD8, PSMB9, SIRT2, RAD23A, PSMB6, PSMG2, PSMB8, PSMA5, PSMG3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| PSMA4, KIAA0101, PSMB4, HDAC2, PSMA1, POMP, PSMB1, PSMA6, PARK2, PSMA2, PSMA7, PSMA3, NEDD8, PSMB9, RPS27A, PSMG1, PSMB5, PSMG2, PSMB8, PSMA5, PSMG3 (tumor) | PSMA4, TRAF6, SUMO2, KIAA0101, PSMB4, PSMA1, POMP, PSMB1, PSMA2, PSMB7, SIRT1, PSMA7, PSMA3, NEDD8, PSMB9, PSMG1, PSMB6, PSMG2, PSMB8, PSMA5, PSMG3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| PSMA4, SUMO2, PSMB4, HDAC2, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, PSMA7, PSMA3, NEDD8, PSMB9, RPS27A, PSMG1, PSMB6, PSMG2, PSMB8, PSMA5, PSMG3 (tumor) | PSMA4, TRAF6, SUMO2, KIAA0101, PSMB4, NFKB1, PSMA1, POMP, PSMB1, PSMA6, PSMB7, PSMA7, PSMA3, NEDD8, RPS27A, PSMG1, RAD23A, PSMG2, PSMB8, PSMA5, PSMG3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| PSMA4, CSNK2A1, SUMO2, KIAA0101, PSMB4, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, PSMA7, PSMA3, NEDD8, RPS27A, PSMG1, PSMB5, PSMB6, PSMG2, PSMA5, PSMG3 (tumor) | PSMA4, TRAF6, PSMB4, NFKB1, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, SIRT1, PSMA7, PSMA3, NEDD8, PSMB9, RPS27A, PSMG1, PSMB5, PSMB6, PSMA5, PSMG3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| PSMA4, SUMO2, PSMB4, HDAC2, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, PSMA7, PSMA3, NEDD8, RPS27A, PSMG1, PSMB5, PSMB6, PSMG2, PSMB8, PSMA5, PSMG3 (tumor) | PSMA4, SUMO2, KIAA0101, PSMB4, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, UCHL5, PSMA7, PSMA3, NEDD8, RPS27A, PSMG1, PSMB5, PSMB6, PSMG2, PSMA5, PSMG3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| PSMA4, SUMO2, PSMB4, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, PSMA7, PSMA3, NEDD8, PSMB9, RPS27A, PSMG1, PSMB5, PSMB6, PSMG2, PSMB8, PSMA5, PSMG3 (tumor) | PSMA4, SUMO2, KIAA0101, PSMB4, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, UCHL5, PSMA7, PSMA3, NEDD8, RPS27A, PSMG1, PSMB5, PSMB6, PSMG2, PSMA5, PSMG3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| PSMA4, SUMO2, KIAA0101, PSMB4, PSMA1, POMP, PSMB1, PSMA2, PSMB7, PSMA7, NEDD8, PSMB9, RPS27A, SIRT2, PSMB5, RNF185, PSMG2, BHLHE41, PSMB8, C2, PSMA5 (tumor) | PSMA4, CSNK2A1, TRAF6, PSMB4, SIRT3, FKBP8, NFKB1, POMP, PSMA6, PSMA2, PSMB7, SIRT1, PSMA7, PSMA3, NEDD8, RPS27A, PSMB5, PSMB6, PSMG2, PSMA5, PSMG3 (normal) |
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| STAD (tumor) | STAD (normal) |
| PSMA4, TRAF6, UBC, PSMB4, NFKB1, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, PSMA7, PSMA3, NEDD8, PSMB9, PSMB5, PSMB6, PSMG2, PSMB8, PSMA5, PSMG3 (tumor) | PSMA4, SUMO2, KIAA0101, PSMB4, PLK1, PSMA1, POMP, PSMB1, PSMA6, PARK2, PSMA2, PSMB7, PSMA3, NEDD8, PSMB9, PSMG1, PSMB6, PSMG2, PSMB8, PSMA5, PSMG3 (normal) |
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| THCA (tumor) | THCA (normal) |
| PSMA4, CSNK2A1, TRAF6, SUMO2, PSMB4, PSMA1, POMP, PSMB1, PSMA6, PARK2, PSMA2, PSMB7, SIRT1, PSMA7, PSMA3, NEDD8, RPS27A, PSMG1, PSMB6, PSMA5, PSMG3 (tumor) | PSMA4, CSNK2A1, SUMO2, PSMB4, PSMA1, POMP, PSMB1, PSMA6, PSMA2, PSMB7, SIRT1, PSMA7, PSMA3, NEDD8, PSMB9, PSMG1, PSMB6, PSMG2, PSMB8, PSMA5, PSMG3 (normal) |
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| TissGeneProg for PSMA4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PSMA4 |
| TissGeneDrug for PSMA4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PSMA4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0242379 | Malignant neoplasm of lung | 6 | BeFree,GAD |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | GAD |
| umls:C0019693 | HIV Infections | 1 | CTD_human |
| umls:C0023903 | Liver neoplasms | 1 | CTD_human |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0024121 | Lung Neoplasms | 1 | BeFree |
| umls:C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| umls:C0038454 | Cerebrovascular accident | 1 | GAD |
| umls:C0038525 | Subarachnoid Hemorrhage | 1 | GAD |
| umls:C0151699 | Intracranial Hemorrhages | 1 | GAD |
| umls:C0206657 | Alveolar Soft Part Sarcoma | 1 | BeFree |
| umls:C2937358 | Cerebral Hemorrhage | 1 | GAD |
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