TissGeneSummary for C15orf39 |
Gene summary |
Basic gene information | Gene symbol | C15orf39 |
Gene name | chromosome 15 open reading frame 39 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 15q24.2 | |
Type of gene | protein-coding | |
RefGenes | NM_015492.4, | |
Description | uncharacterized protein C15orf39 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000167173 | ||
HPRD : 13154 | ||
Vega : OTTHUMG00000142820 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C15orf39 | |
BioGPS: 56905 | ||
Pathway | NCI Pathway Interaction Database: C15orf39 | |
KEGG: C15orf39 | ||
REACTOME: C15orf39 | ||
Pathway Commons: C15orf39 | ||
Context | iHOP: C15orf39 | |
ligand binding site mutation search in PubMed: C15orf39 | ||
UCL Cancer Institute: C15orf39 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLTGCT | |
Reference showing the relevant tissue of C15orf39 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C15orf39 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for C15orf39 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C15orf39 |
TissGeneSNV for C15orf39 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P379S | SKCM | 2 |
p.T877M | THCA | 1 |
p.T375I | UCEC | 1 |
p.P460S | SKCM | 1 |
p.A2T | STAD | 1 |
p.S536* | BLCA | 1 |
p.V633A | UCEC | 1 |
p.G188D | ACC | 1 |
p.P745T | LUSC | 1 |
p.R658C | SKCM | 1 |
p.P834L | SKCM | 1 |
p.E946K | KICH | 1 |
p.P668Q | SKCM | 1 |
p.G999S | GBM | 1 |
p.L127V | HNSC | 1 |
p.A797D | PAAD | 1 |
p.K619E | PAAD | 1 |
p.G76S | COAD | 1 |
p.L1015H | UCEC | 1 |
p.R882Q | HNSC | 1 |
p.R895H | PRAD | 1 |
p.F654L | BLCA | 1 |
p.R895C | HNSC | 1 |
p.D761N | BRCA | 1 |
p.P344L | SKCM | 1 |
p.M638I | UCEC | 1 |
p.P698L | SKCM | 1 |
p.H457Y | BLCA | 1 |
p.S1027F | HNSC | 1 |
p.R903H | BLCA | 1 |
p.E244Q | OV | 1 |
p.P991L | SKCM | 1 |
p.F651I | LUAD | 1 |
p.S686F | BLCA | 1 |
p.V647M | BLCA | 1 |
p.R192W | UCS | 1 |
p.R874W | ESCA | 1 |
p.D826N | STAD | 1 |
p.K152Q | COAD | 1 |
p.T877M | GBM | 1 |
p.D504N | BLCA | 1 |
p.R923H | UCEC | 1 |
p.P306L | SKCM | 1 |
p.P56L | SKCM | 1 |
p.S861F | LUAD | 1 |
p.E448D | UCEC | 1 |
p.E931K | BLCA | 1 |
p.K817E | KIRP | 1 |
p.C41Y | BLCA | 1 |
p.E438D | OV | 1 |
p.Q424L | LUAD | 1 |
p.V666M | STAD | 1 |
p.R153M | BRCA | 1 |
p.A422V | THYM | 1 |
p.R903H | COAD | 1 |
p.S879L | HNSC | 1 |
p.R731Q | SKCM | 1 |
p.G265R | LUAD | 1 |
p.P336L | HNSC | 1 |
p.P399S | SKCM | 1 |
p.G356D | STAD | 1 |
p.S820Y | HNSC | 1 |
p.R918S | COAD | 1 |
p.P336S | SKCM | 1 |
p.R481W | PAAD | 1 |
p.P12H | LGG | 1 |
p.C139R | LIHC | 1 |
p.R20C | UCEC | 1 |
p.G314A | BLCA | 1 |
p.A119P | BRCA | 1 |
p.S169L | BLCA | 1 |
p.R453Q | READ | 1 |
p.P487L | SKCM | 1 |
p.P173L | SKCM | 1 |
p.E792G | UCEC | 1 |
p.S377I | LGG | 1 |
p.S248N | SARC | 1 |
p.R903C | BRCA | 1 |
p.G54S | SKCM | 1 |
p.R290H | BLCA | 1 |
p.R192Q | KIRP | 1 |
p.R229W | CESC | 1 |
p.D158H | BLCA | 1 |
p.P558L | BLCA | 1 |
p.P259Q | STAD | 1 |
p.A412V | SKCM | 1 |
p.P890S | LIHC | 1 |
p.P688S | SKCM | 1 |
p.A749T | COAD | 1 |
p.P432H | PAAD | 1 |
p.P399L | SKCM | 1 |
p.R918C | COAD | 1 |
p.R652X | DLBC | 1 |
p.A348S | LUAD | 1 |
p.G188V | BLCA | 1 |
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TissGeneCNV for C15orf39 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C15orf39 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF883434 | EPS8L1-C15orf39 | chr19:55598113 | chr15:75502932 | |
Chimerdb3.0 | ChiTaRs | NA | AI755186 | AAAS-C15orf39 | chr12:53701314 | chr15:75498882 | |
Chimerdb3.0 | ChiTaRs | NA | AI952989 | C15orf39-TEAD4 | chr15:75504508 | chr12:3149778 | |
Chimerdb3.0 | ChiTaRs | NA | AF495726 | C15orf39-LOC400946 | chr15:75503862 | chr2:20069636 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-A1-A0SG-01A | ZMYM4-C15orf39 | CDS-5'UTR | chr1:35734686 | chr15:75498339 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A8NI-01A | SPRED1-C15orf39 | CDS-5'UTR | chr15:38591748 | chr15:75498339 |
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TissGeneNet for C15orf39 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C15orf39 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C15orf39 |
TissGeneDrug for C15orf39 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C15orf39 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |